Evaluation of using urine reagent strips in the diagnosis of childhood meningitis

Abdelmotaleb, Ghada S.; Abdo, Mohammed K.; Behiry, Eman G.; Mahmoud, Manar I.

doi:10.1097/01.mjx.0000511316.35322.38

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Glucose reagent strip positivity had sensitivity (96.8%) and (100%) specificity. The sensitivity and specificity were high and acceptable (as observed in our study except in protein) (9). The study of (Kathy et al,2018) in Uganda showed that the strip had a high sensitivity (94.9%) and specificity for proteins (79%) (Although the specificity for leucocyte (81.8%) was acceptable, the strip had only a moderate sensitivity for leucocytes (63.6%) .…”

Section: Dbcuulonsupporting

confidence: 71%

Evaluation of using urine strip in diagnosis of children's meningitis in Benghazi-Libya

Al-fituri,

Shabon,

ALmchdwi

et al. 2020

BUMJ

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Background: Bacterial meningitis is still considered as one of the most dangerous infectious diseases, which numerous complications and high mortality if not diagnosed and treated timely. Objective: to evaluate the usefulness of urine reagent strip tests in the diagnosis of meningitis Patients and methods: ninety of children aged less than 11 years were included. They clinically suspected to have meningitis from Benghazi children's hospital in the period from February 2017 to April 2018. CSF samples were tested using both Combur-10 urinary reagent strip and CSF microscopy examination as reference standards. Combur-10 was used to estimate ten parameters including protein, glucose, and leukocytes. Results: The diagnostic accuracy of protein estimation by reagent atrin show 91.7% sensitivity. 100% speciicity for detection of CSF proteins, Glucose reagent strip positivity had 97.5% sensitivity and 72.7% specificity for detection of CSF glucose. Leukocyte esterase positivity by test strip had sensitivity of 100% and specificity of 98.8% for the detection of CSF granulocytes of more than 10 granulocytea/mm. The majority of meningitis were found in children aged less than2 years 191.1%), and incidence of meningitis was found the same percentage in both males and females (41%) for each Conclusions: our results suggest that reagent strips may be a useful additional resource in the diagnosis of bac terial meningitis, especially when it is difficult to collect a sufficient amount of cerebrospinal fluid or to indicate the initial treatment.

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Section: Dbcuulonsupporting

confidence: 71%

Evaluation of using urine strip in diagnosis of children's meningitis in Benghazi-Libya

Al-fituri,

Shabon,

ALmchdwi

et al. 2020

BUMJ

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“…At present, no rapid point-of-care tests are available to detect meningitis. 2,[5][6][7] Several studies have showed the utility of urine reagent strips for the detection of CSF cells, protein, and glucose. 3,[5][6][7][8][9][10][11] Urine reagent strips are made of plastic or paper which have pads impregnated with chemical which will change color when it comes in contact with urine or any fluid, and provide a semi-quantitative assessment of CSF cellularity and biochemistry.…”

Section: Introductionmentioning

confidence: 99%

“…2,[5][6][7] Several studies have showed the utility of urine reagent strips for the detection of CSF cells, protein, and glucose. 3,[5][6][7][8][9][10][11] Urine reagent strips are made of plastic or paper which have pads impregnated with chemical which will change color when it comes in contact with urine or any fluid, and provide a semi-quantitative assessment of CSF cellularity and biochemistry. 12 It is a simple, rapid, and costeffective method for analyzing CSF that does not require any expertise and can be used for diagnosis of meningitis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of urine reagent strips for analysis of cerebrospinal fluid cellularity and biochemical parameters

et al. 2022

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Background: Meningitis is a severe infection affecting the central nervous system requiring early management to prevent debilitating consequences and death. Detection of meningitis can be done by the analysis of cerebrospinal fluid cellularity and biochemistry (glucose and protein concentration). Urine reagent strips can be used to assess these variables and reach to the diagnosis of meningitis early, thereby, reducing the delay in the initiation of its treatment. Aims and Objectives: The current study aimed to determine the efficacy of urine reagent strips for the analysis of CSF. Materials and Methods: The current prospective study was done in a tertiary care center in Rewa, M.P., on 100 cerebral spinal fluid (CSF) samples obtained from the children suspected of meningitis, which were, then, analyzed by both the conventional methods of CSF analysis (including routine biochemical and microscopic analysis) the index test, utilizing the Combur-10 urine reagent strips for the estimation of CSF cell, protein, and glucose. These results were, then, correlated to calculate the diagnostic utility of urine reagent strips for the rapid diagnosis of meningitis. Results: The sensitivity, specificity, and diagnostic accuracy of urine reagent strips for the detection of cell count >10/cumm were 81.81%, 98.21%, and 91%, respectively, and 78.57%, 81.25%, and 79% for detection of protein >30 mg/dL. Reagent strips showed a sensitivity and specificity of 96.85% and 79.41% for the detection of glucose levels <50 mg/dL. The two methods showed an almost perfect degree of agreement for the detection of leucocytes with Cohen’s kappa value of 0.86. Conclusion: Reagent strips can be a helpful bedside screening test for the detection of meningitis and also in resource-limited settings.

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“…6 Even in the settings where they are available, the turnaround time period for laboratory based CSF analysis is long. [5,6,7] The use of urine reagent strips for quick cerebrospinal fluid (CSF) tests has been described in few studies 8 but the results are variable and the method has not gained popularity. Index test was done using urinary reagent strips which can detect ten parameters including protein, glucose, and leukocyte esterase.…”

Section: Introductionmentioning

confidence: 99%

Utility of Urine Reagent Strips in CSF Analysis as An Aid to Rapid Diagnosis of Meningitis

Prabhu

2020

Ann of Pathol and Lab Med

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Background: Bacterial Meningitis is a medical emergency and timely intervention has an implication on the prognosis and outcome. Examination of the CSF for leucocytes, glucose and proteins are the cornerstones in the diagnosis of meningitis in general and to arrive at the cause. Hence, this study is done to evaluate the usefulness of urinary reagent strip for rapid diagnosis of meningitis. Methods: This is a prospective single blinded study on 100 CSF samples subjected to index test (Urine reagent strip test-Dirui H10) and definitive test comprised of CSF microscopy and biochemical analysis for proteins and sugar. The diagnostic accuracy of each index test at different cut off levels tabulated in the form of sensitivity, specificity, PPV and NPV. Result: The sensitivity and specificity for leukocytes by the strip method for ≥15 cells/cumm were 92% and 98.66%, and for protein levels >30 mg/dl were 84.33% and 94.11% respectively. The test showed high specificity (100%) but less sensitivity for glucose <50mg/dl. It was observed that the accuracy of the tests increased with increase in the values of cell counts and proteins and decrease in sugar reaching 100% accuracy for higher cut-offs. Conclusion: Urine reagent strip can be utilized for the rapid analysis of CSF in both rural areas as well as in centres where the facility is available as it reduces turnaround time.

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Evaluation of using urine reagent strips in the diagnosis of childhood meningitis

Cited by 3 publications

References 12 publications

Evaluation of using urine strip in diagnosis of children's meningitis in Benghazi-Libya

Evaluation of using urine strip in diagnosis of children's meningitis in Benghazi-Libya

Efficacy of urine reagent strips for analysis of cerebrospinal fluid cellularity and biochemical parameters

Utility of Urine Reagent Strips in CSF Analysis as An Aid to Rapid Diagnosis of Meningitis

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