Evaluation of Usefulness of Three Serological Tests Using Native Crude Antigen in Diagnosis of Hepatic Cystic Echinococcosis Patients

Akıl, Mesut; Ozkeklikci, Ahmet; Öztürk, Emel; Sadıqova, Aygül; Altıntaş, Nuray; Karamil, Selda; Yılmaz, Özge; Ünver, Ayşegül; Altıntaş, Nazmiye

doi:10.4236/ojmm.2021.112006

Cited by 1 publication

(2 citation statements)

References 27 publications

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“… 21 Serological tests include enzyme-linked immunosorbent assay (ELISA), indirect hemagglutination assay (IHA) and Western blotting (WB), which may play a role in diagnosing liver CE. 4 , 13 , 22 Enzyme-linked immunosorbent assay (ELISA) is considered the gold standard serological test for liver-only hydatid involvement. Immunoglobulin G (IgG) ELISA detects E. granulosus -specific antigen with a sensitivity of 93.5% and specificity of 89.7%.…”

Section: Laboratory Investigationsmentioning

confidence: 99%

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Liver cystic echinococcosis: a parasitic review

Govindasamy

Bhattarai

John

2023

Therapeutic Advances in Infection

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Liver cystic echinococcosis (CE), known as hydatid disease, is caused by the tapeworm Echinococcus granulosus sensu lato. Humans are accidental hosts in this zoonotic disease process, and hepatic infection accounts for over two-thirds of all cases. Since signs and symptoms are mainly non-specific, especially in early disease, clinicians should have a low threshold to include CE as a differential diagnosis in patients with positive serology and suggestive radiological findings, especially in endemic regions. The standard management for liver CE depends on the patient’s symptoms, the radiological stage, the size and location of the cyst, the presence of complications and the treating clinicians’ expertise. In this review, we discuss the lifecycle of Echinococcus granulosus sensu lato and its epidemiology and then focus on discussing the clinical features, diagnosis and treatment options of CE of the liver.

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Section: Laboratory Investigationsmentioning

confidence: 99%

“…Drawbacks with WB are that the test is expensive, and sensitivity rates reduce dramatically in extra-hepatic disease. 4 , 13 , 22 IHA testing has a sensitivity of 90%; however, if the result is positive, it may remain positive for several years after that. 23 …”

Section: Laboratory Investigationsmentioning

confidence: 99%