Evaluation of Use of Shorter Radiation Regimens for Breast and Prostate Cancer in the US, 2015-2017

Gillespie, Erin F.; Tringale, Kathryn R.; Bekelman, Justin E.

doi:10.1001/jamanetworkopen.2020.10519

Cited by 2 publications

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“…Consistent with prior studies, 35 our results demonstrate that uptake of hypofractionated regimens continues to rise in the United States. Over one in three women and one in five men received short-course radiation for BC or PC in 2017 ( v < 1% for either cancer in 2004).…”

Section: Discussionsupporting

confidence: 91%

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Shorter Radiation Regimens and Treatment Noncompletion Among Patients With Breast and Prostate Cancer in the United States: An Analysis of Racial Disparities in Access and Quality

Dee

Taunk

Chino

et al. 2023

JCO Oncology Practice

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PURPOSE: Compared with conventional external-beam radiation therapy (cEBRT) for patients with breast cancer (BC) and prostate cancer (PC), shorter radiation regimens may be associated with lower treatment noncompletion rates. We assess disparities in receipt of shorter radiation regimens and treatment noncompletion for BC and PC. PATIENTS AND METHODS: The 2004-2017 National Cancer Database was queried for adjuvant cEBRT or hypofractionated EBRT (hEBRT) for nonmetastatic BC; and definitive cEBRT, moderate hypofractionation (mEBRT), or stereotactic body radiotherapy (SBRT) for localized PC. Multivariable logistic regression identified factors associated with treatment noncompletion and receipt of shorter regimens. FINDINGS: We identified 170,386 men with PC (median age [interquartile range], 70 [64-75] years; Black, 17.5%; White, 82.5%) and 306,846 women with BC (61 [52-69] years; Black, 12.3%; White, 87.7%). Among patients who received cEBRT for PC, Black men had higher treatment noncompletion rates compared with White (14.1% v 13.0%; odds ratio [95% CI] 1.07 [1.03 to 1.12]; P < .001). In contrast, treatment noncompletion was not disparate with SBRT (Black 1.6% v White 1.3%; 1.20 [0.72 to 2.00], P = .49) or mEBRT (Black 9.0% v White 7.1%; 1.05 [0.72 to 1.54], P = .79). From 2004 to 2017, SBRT (0.07% to 11.8%; 1.32 [1.31 to 1.33]) and mEBRT (0.35% to 9.1%; 1.27 [1.25 to 1.28]) increased (both P < .001); however, Black men were consistently less likely to receive SBRT (7.4% v White, 8.3%; 0.84 [0.79 to 0.89], P < .001). Among women with BC, there were no racial differences in treatment noncompletion; however, hEBRT was associated with lower treatment noncompletion rates (1.0% v cEBRT 2.3%; 0.39 [0.35 to 0.44], P < .001). Although hEBRT for BC increased (0.8% to 35.6%) between 2004 and 2017, Black women were less likely to receive hEBRT (10.4% v 15.3%; 0.78 [0.75 to 0.81], P < .001). INTERPRETATION: Black patients were consistently less likely to receive hypofractionated radiation for PC or BC, despite evidence suggesting that shorter regimens may lower rates of treatment noncompletion with similar oncologic outcomes.

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Section: Discussionsupporting

confidence: 91%

“…Consistent with prior studies, 35 our results demonstrate that uptake of hypofractionated regimens continues to rise in Abbreviations: HER2, human epidermal growth factor receptor 2; HR, hormone receptor; IMRT, intensity-modulated radiation therapy; OR, odds ratio; TNBC, triple-negative breast cancer; USD, US dollars.…”

Section: Discussionsupporting

confidence: 89%

Shorter Radiation Regimens and Treatment Noncompletion Among Patients With Breast and Prostate Cancer in the United States: An Analysis of Racial Disparities in Access and Quality

Dee

Taunk

Chino

et al. 2023

JCO Oncology Practice

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Trends in Utilization and Medicare Spending on Short-Course Radiation Therapy for Breast and Prostate Cancer: An Episode-Based Analysis From 2015 to 2019

Patel,

Jain,

Vapiwala

et al. 2024

International Journal of Radiation Oncology*Biology*Physics

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Evaluation of Use of Shorter Radiation Regimens for Breast and Prostate Cancer in the US, 2015-2017

Abstract: Author affiliations and article information are listed at the end of this article.

Cited by 2 publications

References 5 publications

Shorter Radiation Regimens and Treatment Noncompletion Among Patients With Breast and Prostate Cancer in the United States: An Analysis of Racial Disparities in Access and Quality

Shorter Radiation Regimens and Treatment Noncompletion Among Patients With Breast and Prostate Cancer in the United States: An Analysis of Racial Disparities in Access and Quality

Trends in Utilization and Medicare Spending on Short-Course Radiation Therapy for Breast and Prostate Cancer: An Episode-Based Analysis From 2015 to 2019

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