Evaluation of urinary limonene metabolites as biomarkers of exposure to greenness

Xie, Zhengzhi; Sutaria, Saurin R.; Chen, Jin Y.; Gao, Hong; Conklin, Daniel J.; Keith, Rachel J.; Srivastava, Sanjay; Lorkiewicz, Pawel; Bhatnagar, Aruni

doi:10.1016/j.envres.2023.117991

Cited by 1 publication

(1 citation statement)

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“…Indeed, in our recent work, limonene exposure was increased in participants exposed briefly to a forested area. 121 We found that spending 4 hours in a deciduous forest dominated by broad-leaf trees and shrubs (maple, cherry, ash) led to a 1.6-fold increase in the urinary metabolites of limonene. 121 Identification of the urinary metabolites of other bVOCs and relating their exposure levels to cardiovascular changes could provide new insights into the processes by which exposure to greenness affects human physiology and the chemical links between plants and humans.…”

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 75%

Greenspaces And Cardiovascular Health

Keith,

Hart,

Bhatnagar

2024

Circulation Research

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Accumulating evidence suggests that living in areas of high surrounding greenness or even brief exposures to areas of high greenery is conducive to cardiovascular health, which may be related to the environmental, social, psychological, and physiological benefits of greenspaces. Recent data from multiple cross-sectional, longitudinal, and cohort studies suggest that living in areas of high surrounding greenness is associated with a lower risk of all-cause and cardiovascular mortality. High levels of neighborhood greenery have been linked also to a decrease in the burden of cardiovascular disease risk factors as reflected by lower rates of hypertension, dyslipidemia, and diabetes. Those who live in greener environments report better mental health and more frequent social interactions, which can benefit cardiovascular health as well. In this narrative review, we discuss evidence linking greenspaces to cardiovascular health as well as the potential mechanisms underlying the beneficial effects of greenspaces, including the impact of vegetation on air, noise and light pollution, ambient temperature, physical activity, mental health, and biodiversity. We review literature on the beneficial effects of acute and chronic exposure to nature on cardiovascular disease risk factors, inflammation and immune function, and we highlight the potential cardiovascular effects of biogenic volatile organic compounds that are emitted by trees and shrubs. We identify current knowledge gaps in this area and underscore the need for additional population studies to understand more clearly and precisely the link between greenness and health. Such understanding is urgently needed to fully redeem the promise of greenspaces in preventing adverse environmental exposures, mitigating the effects of climate change, and creating healthier living environments.

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Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 75%