Evaluation of Urinary Inverted Papillomas: A Report of 13 Cases and Literature Review

Kilciler, Mete; Bedir, Selahattin; Erdemır, Fikret; Ors, Onder; Kïbar, Yusuf; Dayanç, Murat

doi:10.1016/s1607-551x(08)70069-x

Cited by 13 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 Papilloma constitutes 1-2% of urothelial tumors. 6 Some authors explain that papilloma lesions are not true neoplasia, but as a hyperplastic reaction of Brune cells against irritative agents or chronic inflammation. 3 However, the general opinion is that the papilloma is a true neoplasm of the urogenital system.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bladder Papilloma As A Rare Cause Of Urogenital Bleeding In A Prepubertal Girl

Kurtoğlu¹,

Armut²,

Öztürk³

2021

J. Pediatr. Acad.

View full text Add to dashboard Cite

There are different causes of urogenital bleeding in prepubertal girls. These include vulvovaginitis, urinary infections, urethral prolapse, urethral caruncle, vaginal foreign bodies, hormonal causes, tumors, posterior labial fusion, lichen sclerosis. Among the tumors, rhabdomyosarcoma and papilloma are prominent. In this article, a case of urogenital hemorrhage due to papilloma located at the base of the bladder was presented and the relevant literature was reviewed

show abstract

Section: Discussionmentioning

confidence: 99%

“…Endocrine tests, pelvic ultrasonography and magnetic resonance should be performed in necessary cases. [1][2][3]6…”

Section: Discussionmentioning

confidence: 99%

Bladder Papilloma As A Rare Cause Of Urogenital Bleeding In A Prepubertal Girl

Kurtoğlu¹,

Armut²,

Öztürk³

2021

J. Pediatr. Acad.

View full text Add to dashboard Cite

show abstract

“…We speculate that these buds, to a small extent, mimic the phenotype of inverted papillomas, a rare human ureter disorder. In this disease, the ureteric urothelium extends cords of epithelial cells in away from the organ's lumen . In future, it may be informative to analyse expression of TGFβ axis molecules in these benign tumours.…”

Section: Discussionmentioning

confidence: 99%

Overactivity or blockade of transforming growth factor‐β each generate a specific ureter malformation

Lopes

Roberts

Zeef

et al. 2019

The Journal of Pathology

View full text Add to dashboard Cite

Transforming growth factor- (TGF) has been reported to be dysregulated in malformed ureters. There exists, however, little information on whether altered TGF levels actually perturb ureter development. We therefore hypothesised that TGF has functional effects on ureter morphogenesis. Tgfb1, Tgfb2 and Tgfb3 transcripts coding for TGF ligands, as well as Tgfbr1 and Tgfbr2 coding for TGF receptors, were detected by quantitative polymerase chain reaction in embryonic mouse ureters collected over a wide range of stages. As assessed by in situ hybridisation and immunohistochemistry, the two receptors were detected in embryonic urothelia. Next, TGF1 was added to serum-free cultures of embryonic day 15 mouse ureters. These organs contain immature smooth muscle and urothelial layers and their in vivo potential to grow and acquire peristaltic function can be replicated in serum-free organ culture. Such organs therefore constitute a suitable developmental stage with which to define roles of factors that affect ureter growth and functional differentiation. Exogenous TGF1 inhibited growth of the ureter tube and generated cocoon-like dysmorphogenesis. RNA sequencing suggested that altered levels of transcripts encoding certain fibroblast growth factors (FGFs) followed exposure to TGF. In serum-free organ culture exogenous FGF10 but not FGF18 abrogated certain dysmorphic effects mediated by exogenous TGF1. To assess whether an endogenous TGF axis functions in developing ureters, embryonic day 15 explants were exposed to TGF receptor chemical blockade; growth of the ureter was enhanced, and aberrant bud-like structures arose from the urothelial tube. The muscle layer was attenuated around these buds, and peristalsis was compromised. To determine whether TGF effects were limited to one stage, explants of mouse embryonic day 13 ureters, more primitive organs, were exposed to exogenous TGF1, again generating cocoon-like structures, and to TGF receptor blockade, again generating ectopic buds. As for the mouse studies, immunostaining of normal embryonic human ureters detected TGFRI and TGFRII in urothelia. Collectively, these observations reveal unsuspected regulatory roles for endogenous TGF in embryonic ureters, fine-tuning morphogenesis and functional differentiation. Our results also support the hypothesis that the TGF up-regulation reported in ureter malformations impacts on pathobiology. Further experiments are needed to unravel the intracellular signalling mechanisms involved in these dysmorphic responses.

show abstract

“…Certain authors have argued that surveillance protocols, as rigorous as those employed in the management of urothelial carcinoma, appear unnecessary for this benign entity due to its low incidence of recurrence and markedly favorable prognosis during follow-up (8,11). However, it is accepted by the majority of authors that the patients should be followed with endoscopy and radiographic studies similar to those observed in patients with low-grade TCC (15), particularly in upper urinary tract IP cases. As a surveillance protocol of the upper urinary tract IP, we recommend cystoscopy and ultrasonic scans every 6 months for the first 2 years, and then annually.…”

Section: Discussionmentioning

confidence: 99%

Upper urinary tract inverted papillomas: Report of 10 cases

et al. 2012

View full text Add to dashboard Cite

Abstract. The aim of the study was to review the clinical features and treatments of 10 (9 males and 1 female; age range, 61-73 years; median age, 67 years) upper urinary tract inverted papilloma (IP) cases between 1995 and 2010. The clinical syndromes, diagnostic procedures, treatments and results of the follow-up were evaluated. The results showed that the site of tumor development was the ureter in 6 cases and the renal pelvis in 4 cases. It was also identified that 7 tumors developed on the left side and 3 developed on the right side of the ureter and renal pelvis, respectively. A nephroureterectomy was performed in the first 6 cases, while a partial ureterectomy was performed in 3 cases and a local resection was performed endoscopically in 1 case. All but 2 tumors were solitary, ranging from 5 to 30 mm in diameter. Occurrence in association with transitional cell carcinoma was identified in one case. All 10 patients were subject to follow-up (range, 19-120 months; median, 59 months), during which no recurrence was found. Local excision is considered as adequate treatment when upper urinary tract IP is diagnosed according to strictly defined criteria.

show abstract

Evaluation of Urinary Inverted Papillomas: A Report of 13 Cases and Literature Review

Cited by 13 publications

References 26 publications

Bladder Papilloma As A Rare Cause Of Urogenital Bleeding In A Prepubertal Girl

Bladder Papilloma As A Rare Cause Of Urogenital Bleeding In A Prepubertal Girl

Overactivity or blockade of transforming growth factor‐β each generate a specific ureter malformation

Upper urinary tract inverted papillomas: Report of 10 cases

Contact Info

Product

Resources

About