Evaluation of umbilical venous flow volume measured using ultrasound compared to circuit flow volume in the EXTra‐uterine Environment for Neonatal Development (EXTEND) system in fetal sheep

Ozawa, Keiya; Davey, Mary‐Ann; Tian, Zhenjun; Hornick, Matthew A.; Mejaddam, Ali Y.; McGovern, Patrick E.; Flake, Alan W.; Rychik, Jack

doi:10.1002/pd.6041

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“…Regarding flow velocity measurement, the Doppler-derived time-averaged flow velocity of the UV and half the maximum flow velocity of the UV are typically used [ 11 , 12 ]. UVFV measured at the intra-abdominal portion calculated using half the maximum flow velocity of the UV showed a good correlation with the directly measured circuit flow volume in the UV of fetal sheep in the EXTrauterine Environment for Neonatal Development (EXTEND) system [ 13 ]. We previously reported that UVFV measured at the intra-abdominal portion using half the maximum flow velocity of the UV showed good reproducibility with low variance [ 14 ].…”

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confidence: 99%

Ultrasound measurement of umbilical venous flow volume at the intra-abdominal portion in normal fetuses

et al. 2023

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Purpose Umbilical venous flow volume (UVFV) measured using ultrasound can be used to assess placental circulation in a fetus. UVFV measured at the intra-abdominal portion using half the maximum flow velocity of the umbilical vein (UV) has good reproducibility with low variance. However, reference values in previous reports were based on a small number of cases with a wide reference range. In the present study, we evaluated UVFV standard values measured at the intra-abdominal portion in normal Japanese fetuses. Methods Measurements were performed on normal pregnant women during routine ultrasound screening at around 20 or 30 weeks of gestation. The diameter and flow velocity of the UV were measured at the fetal abdomen point between the insertion of the UV and branches of the portal vein. UVFV (ml/min) was calculated as follows: (UV diameter [cm]/2)2 × maximum velocity [cm/s] × 0.5 × 3.14 × 60). Results A total of 278 pregnant women were included in the study. UVFV increased with gestational weeks, and UVFV per estimated fetal weight (EFW) slightly decreased with increasing gestational weeks. The 50th (10th–90th) percentiles of UVFV per EFW at 20, 25, and 30 weeks of gestation were 130 (105–165), 123 (94–147), and 104 (80–131) ml/min/kg, respectively. Conclusion New UVFV reference values measured at the intra-abdominal portion of fetuses using large-scale samples were established. Future studies should assess fetuses under pathologic conditions using UVFV reference values.

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