Evaluation of tyrosinase inhibitory and antioxidant activities of Angelica dahurica root extracts for four different probiotic bacteria fermentations

Wang, Guey‐Horng; Chen, Chih-Yu; Tsai, Teh-Hua; Chen, Ching-Kuo; Cheng, Chiu-Yu; Huang, Yi-Hsin; Hsieh, Min-Chi; Chung, Ying‐Chien

doi:10.1016/j.jbiosc.2017.01.003

Cited by 47 publications

(41 citation statements)

References 27 publications

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“…Another active component of MC, paeoniflorin, was shown to promote dopaminergic neuronal survival in vivo due to the inhibition of monoamine oxidase-B (MAO-B) via the PI3K/AKT signaling pathway 35 . Ethanol extract of ADR showed anti-inflammatory effect by inhibiting cycloxygenase, and NF-κB pathway 36 , 37 and anti-oxidative effects screened by the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay 38 . Imperatorin is a major active ingredient of ADR which shows anti-inflammatory effects and neuroprotective effect against ischemia-reperfusion injury 39 .…”

Section: Discussionmentioning

confidence: 99%

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson’s disease

Jeong

Piao

Kang

et al. 2018

Sci Rep

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Moutan cortex, Angelica Dahurica root, and Bupleurum root are traditional herbal medicines used in Asian countries to treat various diseases caused by oxidative stress or inflammation. Parkinson’s disease (PD) has been associated with mitochondrial dysfunction, but no effective treatment for mitochondrial dysfunction has yet been identified. In this study we investigated the neuroprotective effects of the triple herbal extract DA-9805 in experimental models of PD. DA-9805 was prepared by extracting three dried plant materials (Moutan cortex, Angelica Dahurica root, and Bupleurum root in a 1:1:1 mixture) with 90% ethanol on a stirring plate for 24 h at room temperature and fingerprinted using high-performance liquid chromatography. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active metabolite 1-methyl-4-phenylpyridinium (MPP+), which both exert neurotoxic effects on dopaminergic neurons by inhibiting mitochondrial oxidative phosphorylation (OXPHOS) complex I, were used to make experimental models of PD. In MPP+-treated SH-SY5Y cells, DA-9805 ameliorated the suppression of tyrosine hydroxylase expression and mitochondrial damage on OXPHOS complex 1 activity, mitochondrial membrane potential, reactive oxygen species (ROS) generation, and oxygen consumption rate. In the MPTP-induced subacute PD model mice, oral administration of DA-9805 recovered dopamine content as well as bradykinesia, as determined by the rotarod test. DA-9805 protected against neuronal damage in the substantia nigra pars compacta (SNpc) and striatum. In both in vitro and in vivo models of PD, DA-9805 normalized the phosphorylation of AKT at S473 and T308 on the insulin signaling pathway and the expression of mitochondria-related genes. These results demonstrate that the triple herbal extract DA-9805 showed neuroprotective effects via alleviating mitochondria damage in experimental models of PD. We propose that DA-9805 may be a suitable candidate for disease-modifying therapeutics for PD.

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Section: Discussionmentioning

confidence: 99%

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson’s disease

Jeong

Piao

Kang

et al. 2018

Sci Rep

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“…Wang et al. (2017) analyzed the TYR inhibitory and antioxidant activities of plant extracts fermented by probiotic bacteria. They found an anti‐TYR activity of 44.5% for the L. acidophilus fermentation and 8.0% for the cultivation with Lactobacillus brevis .…”

Section: Resultsmentioning

confidence: 99%

Biochemical and functional properties of wheat middlings bioprocessed by lactic acid bacteria

et al. 2020

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The present study aimed to investigate the bioprocessing of wheat middlings with different lactic acid bacteria (LAB) in order to improve biological activities of this by‐product of wheat flour production. The concentration of lactic acid, reducing sugars, and total phenolics, as well as antioxidant, antibrowning, antibacterial and prebiotic activities of fermented samples were analyzed. All LAB strains were capable to growth on wheat middlings, and pH decreased in the medium associated with lactic acid production during cultivation. Samples inoculated with Lactobacillus plantarum DSM20174 presented the maximum growth, lactic acid concentration above 2 mg/ml, and pH values around 3.8. The amount or reducing sugars decreased after 24 hr growth, except for maltose. Bioprocessed wheat middlings exhibited antioxidant, antibrowning, antibacterial, and prebiotic properties, related with the increase of total phenolic content. Highest values for antioxidant activities were obtained for L. plantarum and Streptococcus thermophilus strains, reaching values around 400 and 640 μM Trolox equivalents (TE) ml–1 for 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) assays, respectively. Bioprocessing techniques using LAB can be an interesting approach to improve the availability of compounds with health‐promoting properties from lignocellulosic waste material. Practical applications The processing of secondary products from wheat milling can represent an important benefit to the industry. Wheat middlings bioprocessed with LAB showed improved biological activities and may represent an interesting ingredient to be incorporated in food and feed formulations.

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“…Fermentation may increase the physiological and bio‐chemical activities of biological substrates by modifying their naturally occurring molecules . Furthermore, fermentation with various species of microorganisms can decrease the cytotoxicity of herbal extracts or generate a wide spectrum of antibacterial activities .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, fermentation with various species of microorganisms can decrease the cytotoxicity of herbal extracts or generate a wide spectrum of antibacterial activities . For example, some probiotics have the potential to produce new antioxidative ingredients or reduce the cytotoxicity of herb extracts by fermentation .…”

Section: Introductionmentioning

confidence: 99%

Renewable sources: applications in personal care formulations

Mellou

Varvaresou

Papageorgiou

2019

Intern J of Cosmetic Sci

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A global tendency for products considered environmentally sustainable, and ecologically obtained led the industry related to personal care formulations to fund the research and the development of personal care/cosmetics containing ingredients from natural resources. Furthermore, consumers are aware of environmental and sustainability issueans, thus not harming the environment represents a key consideration when developing a new cosmetic ingredient. In this study we review some examples of active ingredients or raw materials used in cosmetics/personal care/biomedical products that are coming from either through biotechnological systems, or as byproducts of several industries. A skin formulation containing biosynthetic actives, prepared by us and the study regarding its dermocosmetic properties are also described. The need for the standardization processes, the safety assessment tools, the improvement of the exploitation methods of these renewable sources in order the production to be ecologically and economically better are also discussed.

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Evaluation of tyrosinase inhibitory and antioxidant activities of Angelica dahurica root extracts for four different probiotic bacteria fermentations

Cited by 47 publications

References 27 publications

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson’s disease

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson’s disease

Biochemical and functional properties of wheat middlings bioprocessed by lactic acid bacteria

Renewable sources: applications in personal care formulations

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