Evaluation of Two Femoral Arterial Cannulae With Conventional Non‐Pulsatile and Alternative Pulsatile Flow in a Simulated Adult ECLS Circuit

Abstract

The objective of this study is to evaluate the hemodynamic characteristics of two femoral arterial cannulae in terms of circuit pressure, pressure drop, and hemodynamic energy transmission under non-pulsatile and pulsatile modes in a simulated adult extracorporeal life support (ECLS) system. The ECLS circuit consisted of i-cor diagonal pump and console (Xenios AG, Heilbronn, Germany), an iLA membrane ventilator (Xenios AG), an 18 Fr or 16 Fr femoral arterial cannula (Xenios AG), and a 23/25 Fr Estech remote access perfusion (RAP) femoral venous cannula (San Ramon, CA, USA). The circuit was primed with lactated Ringer's solution and packed red blood cells to achieve a hematocrit of 35%. All trials were conducted at room temperature with flow rates of 1-4 L/min (1 L/min increments). The pulsatile flow settings were set at pulsatile frequency of 75 bpm and pulsatile amplitudes of 1000-4000 rpm (1000 rpm increments). Flow and pressure data were collected using a custom data acquisition system. Total hemodynamic energy (THE) is calculated by multiplying the ratio between the area under the hemodynamic power curve (∫flow × pressure dt) and the area under the pump flow curve (∫flow dt) by 1332. The pressure drop across the arterial cannula increased with increasing flow rate and decreasing cannula size. The pressure drops of 18 Fr and 16 Fr cannulae were 19.4-24.5 and 38.4-45.3 mm Hg at 1 L/min, 55.2-56.8 and 110.9-118.3 mm Hg at 2 L/min, 94.1-105.1 and 209.7-215.1 mm Hg at 3 L/min, and 169.2-172.6 and 376.4 mm Hg at 4 L/min, respectively. Pulsatile flow created more hemodynamic energy than non-pulsatile flow, especially at lower flow rates. The percentages of THE loss across 18 Fr and 16 Fr cannula were 16.0-18.7 and 27.5-30.8% at 1 L/min, 35.1-35.7 and 52.3-53.8% at 2 L/min, 48.3-50.3 and 67.3-68.4% at 3 L/min and 62.9-63.1 and 79.0% at 4 L/min. The hemodynamic performance of the arterial cannula should be evaluated before use in clinical practice. The pressure drops and percentages of THE loss across two cannulae tested using human blood were higher compared to the manufacturer's data tested using water. The cannula size should be chosen to match the expected flow rate. In addition, this novel i-cor ECLS system can provide non-pulsatile and ECG-synchronized pulsatile flow without significantly increasing the cannula pressure drop and hemodynamic energy loss.

Evaluation of centrifugal blood pumps in term of hemodynamic performance using simulated neonatal and pediatric ECMO circuits

“…We intentionally did not include the results from this particular diagonal pump in the materials and methods section of this manuscript, as it has not been approved by the FDA for clinical practice in the United States. The i‐Cor DP3 diagonal pump is also capable of providing pulsatile flow in addition to conventional non‐pulsatile flow . In addition, the i‐Cor pump is capable of providing ECG‐synchronized pulsatile flow by syncing the pulses of the pump with the patient’s native heartbeat.…”

“…The i-Cor DP3 diagonal pump is also capable of providing pulsatile flow in addition to conventional non-pulsatile flow. [17][18][19][22][23][24] In addition, the i-Cor pump is capable of providing ECG-synchronized pulsatile flow by syncing the pulses of the pump with the patient's native heartbeat. We evaluated the i-Cor pump under non-pulsatile and pulsatile modes using the identical experimental settings of this particular investigation.…”

Artificial Organs 2019: A year in review

“…Shigang Wang et al of the Penn State Hershey College of Medicine, Hershey, PA, USA evaluated the hemodynamic characteristics of two femoral arterial cannulae (18 Fr and 16 Fr) in terms of circuit pressure, pressure drop, and hemodynamic energy transmission under nonpulsatile and pulsatile modes in a simulated adult extracorporeal life support (ECLS) system. The pressure drop across the arterial cannula increased with increasing flow rate and decreasing cannula size.…”

Pressure and flow properties of dual-lumen cannulae for extracorporeal membrane oxygenation

“…Therefore, it is a must to perform additional experiments by mimicking the clinical extracorporeal circuits and conditions for the evidence-based selection of cannulae for clinical practice. [2][3][4][5][6] The authors used an identical adult circuitry (with 3/8 in. of arterial and 1/2 in.…”

“…To improve the extracorporeal life support (ECLS) patients' outcomes, translational research is a necessity, not an option. [1][2][3][4][5][6] The French size refers to the outer diameter of all extracorporeal cannulae. In addition to the cannula size, cannula length and wall-thickness have a direct impact on pressure drops.…”