Evaluation of tumour markers in molar pregnancy

Hegab, Hassan Mansour; Schindler, A. E.; Rizk, Mohamed M.; Ramadan, Mohammad

doi:10.1007/s00404-003-0481-1

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…32 In a study published in 2003, serum tumor markers were evaluated and mean CA 19-9 was found to be lower in HM pregnancies compared to normal pregnancies. 33 In a hematologic evaluation, low NK cell percentage was reported to be associated with gestational trophoblastic tumors in the study by Sutoto MT. 34 Considering the studies that focused on hemogram data, mean platelet volume was showed additive effect to predict persistent HM 21.5%, while platelet/lymphocyte ratio was 18.3%, in a study including histologically confirmed 257 HM and 198 normal pregnant women.…”

Section: Discussionmentioning

confidence: 97%

Predictivity of inflammatory cell counts in early diagnosis of hydatidiform mole

Eroğlu

Adalı

2019

Int J Res Med Sci

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Background: Hydatidiform mole (HM) is the most frequently encountered disease among gestational trophoblastic diseases. HM can invade myometrium and result in hysterectomy and because of the absence of any predictive method, the disease can be lately diagnosed in the periphery. Author aimed to evaluate predictive value of the inflammatory cell counts in molar pregnancies in this study.Methods: Nineteen (19) cases with histopathologic HM diagnosis and 19 cases of control group with pregnancy termination or abortion material reached to a university hospital's pathology department on the same day were included in the study. The data on the same day or the day before the operation was used as the hemogram data.Results: The mean age of the cases were 33.84±8.477. The mean of neutrophil, lymphocyte, monocyte, basophil and eosinophil numbers of the HM group and control group were compared in the 95% confidence interval with the independent t test. No statistical significance was observed in any of the inflammatory cell means (p>0.05). The ratio of lymphocyte means was statistically significant (p=0.006).Conclusions: In this study, author assessed whether the inflammatory cell counts were a predictive in detecting HM. The statistically significant results that author founded in the means of lymphocyte, suggests that this finding may be predictive of early diagnosis. They concluded that this result can be routinely used after the confirmation of the results in larger series of cases.

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Section: Discussionmentioning

confidence: 97%

Predictivity of inflammatory cell counts in early diagnosis of hydatidiform mole

Eroğlu

Adalı

2019

Int J Res Med Sci

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“…Tumor markers and certain immune regulatory mediators have previously been investigated in molar pregnancy and choriocarcinoma [18,19]. The potential role of s-HER2 and TGF-β1 as tumor markers in patients with GTDs was investigated in the present study.…”

Section: Discussionmentioning

confidence: 98%

Investigation of Soluble HER2 and Transforming Growth Factor Beta-1 Serum Levels in Gestational Trophoblastic Disease

Dehaghani

Rad

Fattahi

et al. 2008

Pathol. Oncol. Res.

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HER2/neu and TGF-beta1 are over-expressed in various types of malignancies. It appears that they play an important role in the biologic behavior of tumors and have prognostic value. Gestational tropoblastic diseases (GTDs) comprise of a heterogeneous group characterized by abnormally proliferating trophoblastic tissues, ranging from benign to malignant. The objective of this study was to measure and compare the serum levels of s-HER2 and TGF-beta between patients with GTDs and pregnant and non-pregnant controls. Serum levels of s-HER2 and TGF-beta1 were determined by ELISA method in 95 GTD patients (55 complete moles, 32 persistent moles, and 8 choriocarcinoma), 30 normal pregnant controls, and 22 normal non-pregnant controls. Mean serum level of s-HER2 did not differ significantly between patients and controls. TGF-beta1 serum level was significantly higher in GTD patients (20.29 +/- 10.68 pg/ml with 95% confidence interval (CI) of 18.10-22.48 pg/ml) compared with pregnant controls (10.26 +/- 11.84 pg/ml with 95% CI of 5.75-14.76 pg/ml) and non-pregnant controls (7.27 +/- 9.61 pg/ml with 95% CI of 3.01-11.53 pg/ml) (P < 0.001). Our findings suggest that TGF-beta1 serum levels in GTD patients may represent a potential prognostic marker. Further investigations with larger sample size and more frequent sampling are required to elucidate this issue.

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“…Moreover, our research confirmed the results of the systematic review by Han et al [24] which observed that CA 125, CA 15-3 and squamous cell carcinoma antigen levels were elevated during normal pregnancies, whereas anti-Müllerian hormone, inhibin B and lactate dehydrogenase levels were below the physiological range. Compared to Han et al [24], we extended our review of the literature to those articles including also complicated pregnancies [10,[18][19][20][21][22]25]: no significant difference in serum CA 15-3 values between normal and pathological pregnancies emerged, except for one paper by Sharma et al [19] which showed an increase of CA 15-3 in pregnancies complicated by gestational diabetes, intrahepatic cholestasis and heart disease.…”

Section: Discussionmentioning

confidence: 99%

“…Hegab et al [20] compared circulating CA 125, CA 19-9, CA 15-3 and CEA levels between 60 patients with hydatidiform mole and 20 pregnant women with the corresponding duration of pregnancy. No significant statistical difference was found.…”

Section: Literature Reviewmentioning

confidence: 99%

Can we trust tumour markers in pregnancy after breast cancer? A case of elevated CA 15-3 in the third trimester of pregnancy normalising after delivery

Buonomo

Noli

Santini

et al. 2019

ecancer

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We realized a narrative review of the current literature starting from the case of a patient with raised CA15-3 during an uncomplicated pregnancy after breast cancer. The aim of our paper was to assess specificity, physiological changes and clinical utility of CA 15-3 monitoring during pregnancy after breast cancer, starting from clinical practice and retrieving the most relevant evidence in the literature.

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Evaluation of tumour markers in molar pregnancy

Cited by 6 publications

References 7 publications

Predictivity of inflammatory cell counts in early diagnosis of hydatidiform mole

Predictivity of inflammatory cell counts in early diagnosis of hydatidiform mole

Investigation of Soluble HER2 and Transforming Growth Factor Beta-1 Serum Levels in Gestational Trophoblastic Disease

Can we trust tumour markers in pregnancy after breast cancer? A case of elevated CA 15-3 in the third trimester of pregnancy normalising after delivery

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