Evaluation of tuberculosis-associated chronic obstructive pulmonary disease at a tertiary care hospital: A case–control study

Aggarwal, Deepak; Gupta, Anubhav; Janmeja, Ashok Kumar; Bhardwaj, Manisha

doi:10.4103/lungindia.lungindia_522_16

Cited by 24 publications

(10 citation statements)

References 19 publications

(25 reference statements)

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“…Despite its clinical relevance, however, information on this topic is very scarce. 34 35 36 Except for a single prospective study (n = 1,784) that reported worse outcomes, including more hospitalizations among COPD patients with a previous TB history than among those without a previous TB history, 10 other studies have been limited by their relatively small study populations and their study designs, such as a case-control study design 35 or a cross-sectional study design, 34 that make it difficult to confirm the causal inference between a previous TB history and COPD-related hospitalization. Overcoming these limitations by enrolling a larger population and using a longitudinal database, our study provides solid evidence that prior TB is a risk factor for COPD-related hospitalization, emphasizing the importance of TB prevention and management to mitigate TB-related COPD outcomes.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study

Kim,

Choi,

Kim

et al. 2024

J Korean Med Sci

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Background Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls. Methods We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls. Results Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54–1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81–2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17–2.92). Conclusion TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.

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Section: Discussionmentioning

confidence: 99%

Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study

Kim,

Choi,

Kim

et al. 2024

J Korean Med Sci

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“…The overall prevalence of TOPD according to the PLATINO study was 30.7% compared to controls, and the development of obstructive airway disease was an independent risk factor in patients following TB [ 13 ]. According to studies conducted in India, the prevalence of TOPD varies between 15% and 46% [ 9 , 14 - 16 ]. Aggarwal et al reported that almost one-third of COPD patients (32.4%) had an associated history of TB.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to the general population, metabolic syndrome is twice more common in COPD patients, and its prevalence among COPD patients varies from 25.6% to 60.9% in the literature [ 8 ]. Tuberculosis-associated obstructive airway disease (TOPD) forming the TOPD phenotype of COPD is a sequela and complication following tuberculosis, and a considerable number of COPD patients belong to this group [ 9 ]. Because metabolic syndrome is common in COPD patients, we expected that there might be a higher prevalence of metabolic syndrome and its components among TOPD patients.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome in Post-Pulmonary Tuberculosis-Associated Obstructive Airway Disease: A Cross-Sectional Analytical Study

MP¹,

Mohapatra²,

Babu³

et al. 2022

Cureus

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Background The aim of this study is to assess the prevalence of metabolic syndrome in tuberculosis-associated obstructive airway disease (TOPD) patients, as well as the association of its components with the severity of airflow obstruction. Methodology In this cross-sectional analytical study, we evaluated the clinical profile, spirometry, waist circumference, blood pressure, lipid profile, fasting plasma glucose, and the association of each component with the severity of airflow obstruction. Results The prevalence of metabolic syndrome in TOPD was found to be was 25.77% (95% confidence interval = 18.11-35.28) among study participants. Reduced high-density lipoprotein was the deranged component and was associated with increased severity in Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II compared to GOLD stage IV. Conclusions The prevalence of metabolic syndrome in TOPD has a severe impact on patients’ treatment, outcomes, and complications. However, in our study, tuberculosis-associated metabolic syndrome was the same as the general population. Low high-density lipoprotein levels were associated with the severity of the airflow obstruction.

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“…1 Apart from tobacco smoke, COPD has been known to occur in patients with previous pulmonary TB. [2][3][4] Several studies have shown that tuberculosis can independently increase the risk of developing COPD, and having a history of tuberculosis can increase the prevalence of COPD by an average of three times.This elevation can directly correlate with an increased severity of obstruction and level of inflammation, termed Tuberculosis-Associated Obstructive Pulmonary Disease (TOPD). 5 TOPD forming the TOPD phenotype of COPD is a sequela and complication following tuberculosis, and a considerable number of COPD patients belong to this group.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Serum Autoantibody Repertoire and Immune Subgroup Variation of Tuberculosis-Associated Obstructive Pulmonary Disease

Jiang,

Pang,

Wang

et al. 2023

COPD

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Background Studying the potential etiology and pathogenesis of tuberculosis-associated chronic obstructive pulmonary disease (TOPD) from an autoimmunity perspective may provide insights into peripheral blood autoantibodies and immune cells, as well as their interactions. Methods This study examined the serum autoantibody repertoire in healthy individuals, patients with chronic obstructive pulmonary disease (COPD), patients with pulmonary tuberculosis (TB), and TOPD patients using the HuProt TM protein chip. Autoantigens in the peripheral blood of TOPD patients were verified using ELISA assay. Various epitopes and immune simulation were predicted using bioinformatic methods. Flow cytometry was employed to detect macrophages(Mφ), T cells, and innate lymphoid cells (ILCs) in the peripheral blood. Results COPD patients displayed distinct alterations in their IgG and IgM autoantibodies compared to the other groups. GeneOntology (GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses revealed that these autoantibodies were associated with regulating macrophages, T cells, and B cells. ELISA results confirmed the upregulation of expression of proliferating cell nuclear antigen (PCNA), Mitogen-Activated Protein Kinase 3 antigen (MAPK3), and threonine protein kinase 1 antigen (AKT1) proteins in the peripheral blood of TOPD patients. Bioinformatic analysis predicted multiple potential epitopes in Th, CTL, and B cells. Immune simulation results demonstrated that PCNA, MAPK3, and AKT1 can activate innate and adaptive immune responses and induce the expression of different cytokines, such as IFN-g and IL-2. Furthermore, data obtained from flow cytometry assay revealed an upregulation in the face of Th1 cells in the peripheral blood of TOPD patients. Conclusion Tuberculosis infection can effectively induce autoimmune responses, contributing to increased expression of Th1 cells and associated cytokines, ultimately leading to immune dysregulation. Furthermore, the accumulation of pulmonary inflammatory response facilitates the progression of TOPD and is helpful for the clinical diagnosis and the development of targeted therapeutic drugs for this disease.

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Evaluation of tuberculosis-associated chronic obstructive pulmonary disease at a tertiary care hospital: A case–control study

Cited by 24 publications

References 19 publications

Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study

Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study

Metabolic Syndrome in Post-Pulmonary Tuberculosis-Associated Obstructive Airway Disease: A Cross-Sectional Analytical Study

Characteristics of Serum Autoantibody Repertoire and Immune Subgroup Variation of Tuberculosis-Associated Obstructive Pulmonary Disease

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