Evaluation of Treatment Response and Side Effects of Spinal-Z in Patients with Metastatic Gastroesophageal Adenocarcinoma: A Double-Blind Randomized Controlled Trial

Mashak, Banafsheh; Hoseinzadeh, Mehran; Ehsanpour, Ali; Ghanbaran, Ali Reza; Vakili, Mahdis

doi:10.5812/jjcdc.57870

Cited by 9 publications

(11 citation statements)

References 9 publications

(13 reference statements)

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“…7 Moreover methoxylated flavonoids in this plant have various biological and pharmacological qualities including antibacterial, antifungal, anti-inflammatory, antispasmodic, analgesic, antihyperlipidemic, and immunomodulatory properties. [8][9][10] The anticancer property of D. kotschi has been attributed to methoxylated flavones such as apigenin, luteolin, isokaempferid, crisimaritin, penduletin, and xanthomicrol, and the antioxidant activity might be due to the phenolic compounds (like caffeic acid, chlorogenic acid, phenylpropanoids, and flavonoids) present in this plant. 11 Dracocephalum kotschyi has also been used in traditional medicine for stomach and liver disorders, headache, and congestion, as a painkiller, and for the treatment of kidney complications, toothache, and colds.…”

Section: Introductionmentioning

confidence: 99%

“…Xanthomicrol, the most common phytochemical composition in D. kotschyi leaves, possesses an anticancer effect . Moreover methoxylated flavonoids in this plant have various biological and pharmacological qualities including antibacterial, antifungal, anti‐inflammatory, antispasmodic, analgesic, antihyperlipidemic, and immunomodulatory properties . The anticancer property of D. kotschi has been attributed to methoxylated flavones such as apigenin, luteolin, isokaempferid, crisimaritin, penduletin, and xanthomicrol, and the antioxidant activity might be due to the phenolic compounds (like caffeic acid, chlorogenic acid, phenylpropanoids, and flavonoids) present in this plant .…”

Section: Introductionmentioning

confidence: 99%

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Iron oxide nanoparticles: a novel elicitor to enhance anticancer flavonoid production and gene expression in Dracocephalum kotschyi hairy‐root cultures

et al. 2019

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BACKGROUND Dracocephalum kotschyi Boiss. is a valuable source of rosmarinic acid (RA) and methoxylated hydroxyflavones (such as xanthomicrol and cirsimaritin) with antioxidative and antiplatelet effects and with antiproliferative potential against various cancer cells. The extensive application of nanotechnology in hairy root cultures is a new sustainable production platform for producing these active constituents. In the present study, hairy roots derived from 4‐week‐old leaves and Agrobacterium rhizogenes strain ATCC15834 were used to investigate the impact of various concentrations of iron oxide nanoparticles (Fe NPs) in two elicitation time exposures (24 and 48 h) on growth, antioxidant enzyme activity, total phenolic and flavonoid content (TPC and TFC), and some polyphenols. Gene expression levels of phenylalanine ammonia‐lyase (pal) and rosmarinic acid synthase (ras) were also analyzed. RESULTS Iron nanoparticles enhanced biomass accumulation in hairy roots. The treatment time and Fe NP dosage largely improved the activity of antioxidant enzymes, TPC and TFC. The highest RA (1194 μg g−1 FW) content (9.7‐fold), compared to controls, was detected with 24 h of exposure to 75 mg L−1 Fe NP, which was consistent with the expression of pal and ras genes under the influence of elicitation. The xanthomicrol, cirsimaritin, and isokaempferide content was increased 11.87, 3.85, and 2.27‐fold, respectively. CONCLUSION Stimulation of D. kotschyi hairy roots by Fe NPs led to a significant increase in the induction and production of important pharmaceutical compounds such as rosmarinic acid and xanthomicrol. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Iron oxide nanoparticles: a novel elicitor to enhance anticancer flavonoid production and gene expression in Dracocephalum kotschyi hairy‐root cultures

et al. 2019

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“…Nevertheless, essential oils and aerial plant parts were the main components of the D. kotschyi plant that were investigated. Studies of different parts of D. kotschyi plant show that aerial parts of D. kotschyi plants are sources of valuable flavonoids and essential oils [10, 20, 44, 45] while its seeds are rich in linolenic, oleic, and linoleic acids [46]. According to Mashayekhan et al .…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacological studies have confirmed some medicinal properties of D. kotschyi including antinociceptive [23], antihyperlipidemic [20], immunomodulatory [21], and cytotoxic [24] effects. The essential oil from D. kotschyi has strong spasmolytic activities on isolated ileum [67, 68].…”

Section: Discussionmentioning

confidence: 99%

“…Dracocephalum kotschyi plant has been used widely as part of modern medicine for the treatment of many infectious diseases, as well as in the prevention of tumor proliferation across the world [18]. Several biological and pharmacological properties of D. kotschyi have been reported including antibacterial [19], antifungal, and anti-inflammatory [20]. D. kotschyi has a number of medicinal properties among them antispasmodic, analgesic, antihyperlipidemic, and immunomodulatory activities [21, 22].…”

Section: Introductionmentioning

confidence: 99%

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Medicinal Properties and Active Constituents of Dracocephalum kotschyi and Its Significance in Iran: A Systematic Review

Heydari

Yavari

Adibi

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objectives. Dracocephalum has over 60 species and is found mainly in the temperate regions of Asia and Europe. One of these species, i.e., Dracocephalum kotschyi Boiss, is known to have a number of medicinal properties and active ingredients in many parts of the world. Despite being an endemic wild-flowering plant of great importance, the plant is currently considered endangered in Iran. Besides, there is paucity of information on the significance of the medicinal properties and active constituents of D. kotschyi among the Iranian people. On that account a systematic review of studies reporting on the medicinal properties and active ingredients and its significance to human and animal health was conducted and the existing knowledge gaps were identified. Methods. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used in the search for published articles on medicinal properties and active ingredients of D. kotschyi and its significance on humans and animals in Iran. The search was confined to scientific articles from repositories of popular data bases and search engines among them PubMed, Web of Science, Google Scholar, Science Direct, SpringerLink, and Scopus. The search narrowed down on scientific journals, books, and book chapters focusing on the medicinal properties of D. kotschyi in Iran for the period between 1970 and 2018. Results. A total of 1158 scientific articles were sourced from the various databases, out of which 38 met the search criteria and qualified for this review. The studies were conducted in only 9 of the 31 provinces of Iran, with a large proportion in Isfahan province, central Iran. The studies showed that all plant parts (roots, aerial parts, flowers, and leaves) had active constituents. Essential oils and aerial plant parts were the main components studied. Nevertheless, the most frequently reported constituents were xanthomicrol, limonene, luteolin, geranial, apigenin, and calycopterin. A number of medicinal properties were reported among them antioxidant, antibacterial, anticancerous, antinociceptive, antihyperlipidemic, antispasmodic, cytotoxic, and immunomodulatory effects. The plant was also reported to be a remedy for inflammatory pain, headaches, congestion, liver disorders, ulcer, fever, renal pain, dyspepsia, stomach ache, abdominal pain, joints pains, muscle spasm, congestion, bloating, and wound healing effects, among others. Conclusion. This review has shown that D. kotschyi is an important medicinal plant with a large number of active constituents and great potential to safeguard human and animal health in Iran. However, over utilization of the D. kotschyi plant is already endangering its existence. Nevertheless, more studies need be conducted across the country.

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Changes in Yield and Essential Oil Compositions of Dracocephalum kotschyi Boiss in Response to Azocompost, Vermicompost, Nitroxin, and Urea Under Water Deficit Stress

Heidarzadeh

Mokhtassi‐Bidgoli

2021

J Soil Sci Plant Nutr

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Evaluation of Treatment Response and Side Effects of Spinal-Z in Patients with Metastatic Gastroesophageal Adenocarcinoma: A Double-Blind Randomized Controlled Trial

Cited by 9 publications

References 9 publications

Iron oxide nanoparticles: a novel elicitor to enhance anticancer flavonoid production and gene expression in Dracocephalum kotschyi hairy‐root cultures

Iron oxide nanoparticles: a novel elicitor to enhance anticancer flavonoid production and gene expression in Dracocephalum kotschyi hairy‐root cultures

Medicinal Properties and Active Constituents of Dracocephalum kotschyi and Its Significance in Iran: A Systematic Review

Changes in Yield and Essential Oil Compositions of Dracocephalum kotschyi Boiss in Response to Azocompost, Vermicompost, Nitroxin, and Urea Under Water Deficit Stress

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