Evaluation of transient-evoked otoacoustic emissions in a healthy 1 to 10 year pediatric cohort in Sub-Saharan Africa

Dejaco, Daniel; Aregger, Fabian Cedric; Hurth, Helene; Kegele, Josua; Muigg, Veronika; Oberhammer, Lukas; Bunk, Sebastian; Fischer, Natalie; Pinggera, Leyla; Riedl, David; Otieno, Allan; Agbenyega, Tsiri; Adegnika, Ayôla Akim; Riechelmann, Herbert; Lackner, Peter; Zorowka, Patrick; Kremsner, Peter G.; Schmutzhard, Joachim

doi:10.1016/j.ijporl.2017.07.029

Cited by 1 publication

(4 citation statements)

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“…Interestingly, the OAE rate of the followed-up group levelled at approximately 84%. Dejaco et al [29] compared the effect of the recruitment location—in-hospital versus community—on the OAE rates. A significant difference between the two locations could be shown.…”

Section: Discussionmentioning

confidence: 99%

“…As a major downside, TEOAE examination is not equivalent to pure-tone audiometry regarding sensitivity and in-depth analysis of hearing loss; however, an inner-ear deficit of 20–30 dB can be detected [15, 17, 24]. While pure-tone audiometry remains the standard for acoustic screening in children older than 6 years [29], TEOAE examination should be considered a practical and convenient option when screening children of all ages for inner-ear deficits in remote and rural settings such as sub-Saharan African villages.…”

Section: Discussionmentioning

confidence: 99%

“…Using the same control group as in the initial study can be counted as a limitation, foremost because age-matching proved difficult as the control group had been designed to fit the initial study. Instead, the whole representative collective was reused as a control cohort instead of age-matching every followed-up patient with a child included in the control group [28, 29].…”

Section: Discussionmentioning

confidence: 99%

“…The follow-up study was designed as a prospective study and aimed to repeat transient OAE measurements in children, which had been included in the prior study in 2011 at the Centre de Recherches Médicales Lambaréné. The achieved results were compared to the primary control population [28, 29]. The patients were evaluated partly at the research facility, partly in their home.…”

Section: Methodsmentioning

confidence: 99%

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A long-term follow-up study on otoacoustic emissions testing in paediatric patients with severe malaria in Gabon

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Reider

Lackner

et al. 2019

Malar J

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Background In a previous study, severe and cerebral malaria have been connected with acute cochlear malfunction in children, demonstrated by a decrease of transitory evoked otoacoustic emissions (TEOAEs) reproducibility. This study aims to determine whether cochlear malfunction persists for 4 years after recovery from severe malaria in a subset of the previous study’s collective. Follow-up TEOAEs were performed on site (CERMEL, Hôpital Albert Schweitzer, Lambaréné, Gabon) or at the participants’ homes; 33 out of 90 participants included in the initial investigation by Schmutzhard et al. could be retrieved and were re-examined, 31/33 could be included. Of the 57 missing participants, 51 could not be contacted, 1 had moved away, 4 refused to cooperate, and 1 had died. Methods As in the initial investigation, participants of this prospective follow-up study were subjected to TEOAE examination on both ears separately. A wave correlation rate of > 60% on both ears was considered a “pass”; if one ear failed to pass, the examination was considered a “fail”. The results were compared to the primary control group. Additionally, a questionnaire has been applied focusing on subsequent malaria infections between the primary inclusion and follow-up and subjective impairment of hearing and/or understanding. Results The cohort’s mean age was 9 years, 14 children were female, 18 male. 31 had been originally admitted with severe, one with cerebral malaria. 83.8% of participants (n = 26) presented with a TEOAE correlation rate of > 60% on both ears (the cut-off for good cochlear function); in the control group, 92.2% (n = 83) had passed TEOAE examination on both ears. Recurrent severe malaria was associated with a worse TEOAE correlation rate. Age at infection and gender had no influence on the outcome. Conclusions Cochlear malfunction seems to be persistent after 4 years in more than 16% of children hospitalized for malaria. In a healthy control group, this proportion was 7.8%. Yet, the severity of the initial TEOAE-decrease did not predict a worse outcome. Electronic supplementary material The online version of this article (10.1186/s12936-019-2840-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%