Evaluation of training effectiveness for improving maximal voluntary contraction without noticeable hypertrophy of muscles

Netreba, A. I.; Bravyy, Y. R.; Makarov, V. A.; Ustyuzhanin, D.; Виноградова, О. Л.

doi:10.1134/s0362119711060120

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…muscle mass and phenotype). The causality may thus involve other physiological adaptations such as motoneuron function, 146 which has indeed been suggested to be affected by vitamin D supplementation in rodents 147 …”

Section: Resultsmentioning

confidence: 99%

Vitamin D₃supplementation does not enhance the effects of resistance training in older adults

Mølmen

Hammarström

Pedersen

et al. 2021

J cachexia sarcopenia muscle

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Background Lifestyle therapy with resistance training is a potent measure to counteract age‐related loss in muscle strength and mass. Unfortunately, many individuals fail to respond in the expected manner. This phenomenon is particularly common among older adults and those with chronic diseases (e.g. chronic obstructive pulmonary disease, COPD) and may involve endocrine variables such as vitamin D. At present, the effects of vitamin D supplementation on responses to resistance training remain largely unexplored. Methods Ninety‐five male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years) were randomly assigned to receive either vitamin D3 or placebo supplementation for 28 weeks in a double‐blinded manner (latitude 61°N, September–May). Seventy‐eight participants completed the RCT, which was initiated by 12 weeks of supplementation‐only (two weeks with 10 000 IU/day, followed by 2000 IU/day), followed by 13 weeks of combined supplementation (2000 IU/day) and supervised whole‐body resistance training (twice weekly), interspersed with testing and measurements. Outcome measures included multiple assessments of muscle strength (nvariables = 7), endurance performance (n = 6), and muscle mass (n = 3, legs, primary), as well as muscle quality (legs), muscle biology (m. vastus lateralis; muscle fibre characteristics, transcriptome), and health‐related variables (e.g. visceral fat mass and blood lipid profile). For main outcome domains such as muscle strength and muscle mass, weighted combined factors were calculated from the range of singular assessments. Results Overall, 13 weeks of resistance training increased muscle strength (13% ± 8%), muscle mass (9% ± 8%), and endurance performance (one‐legged, 23% ± 15%; whole‐body, 8% ± 7%), assessed as weighted combined factors, and were associated with changes in health variables (e.g. visceral fat, −6% ± 21%; [LDL]serum, −4% ± 14%) and muscle tissue characteristics such as fibre type proportions (e.g. IIX, −3% points), myonuclei per fibre (30% ± 65%), total RNA/rRNA abundances (15%/6–19%), and transcriptome profiles (e.g. 312 differentially expressed genes). Vitamin D3 supplementation did not affect training‐associated changes for any of the main outcome domains, despite robust increases in [25(OH)D]serum (∆49% vs. placebo). No conditional effects were observed for COPD vs. healthy or pre‐RCT [25(OH)D]serum. In secondary analyses, vitamin D3 affected expression of gene sets involved in vascular functions in muscle tissue and strength gains in participants with high fat mass, which advocates further study. Conclusions Vitamin D3 supplementation did not affect muscular responses to resistance training in older adults with or without COPD.

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Section: Resultsmentioning

confidence: 99%

Vitamin D₃supplementation does not enhance the effects of resistance training in older adults

Mølmen

Hammarström

Pedersen

et al. 2021

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

show abstract

“…muscle mass and phenotype). The causality may thus involve other physiological adaptations such as motoneuron function, 151 which has indeed been suggested to be affected by vitamin D supplementation in rodents. 152 Third, vitamin D 3 supplementation and resistance training led to differential levels of cortisol in blood compared to placebo.…”

Section: Resultsmentioning

confidence: 99%

No benefits of prolonged vitamin D₃ supplementation for adaptations to resistance training in old adults

Mølmen

Hammarström

Pedersen

et al. 2020

Preprint

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Background: Lifestyle therapy with resistance training is a potent measure to counteract age-related loss in muscle strength and mass. Unfortunately, many individuals fail to respond in the expected manner. This phenomenon is particularly common among older adults and those chronically diseased (e.g. chronic obstructive pulmonary disease, COPD), and may involve endocrine variables such as vitamin D. At present, the effects of vitamin D supplementation on responses to resistance training remain largely unexplored. Methods: Ninety-five male and female participants (healthy, n=71; COPD, n=24; age 68 ± 5 years) were randomly assigned to receive either vitamin D3 or placebo supplementation for 28 weeks in a double-blinded manner (latitude 61°N, September-May). Seventy-eight participants completed the RCT, which was initiated by 12 weeks of supplementation-only (in average, 3333 IU.day-1), followed by 13 weeks of combined supplementation (2000 IU.day-1) and supervised whole-body resistance training (twice weekly), interspersed with testing and measurements. Outcome measures included multiple assessments of muscle strength (n=7), endurance performance (n=6), and muscle mass (n=3, legs, primary), as well as muscle quality (legs), muscle biology (m. vastus lateralis; muscle fibre characteristics, transcriptome), and health-related variables (e.g. visceral fat mass and blood lipid profile). For main outcome domains such as muscle strength and muscle mass, weighted combined factors were calculated from the range of singular assessments. Results: Overall, 13 weeks of resistance training increased muscle strength (13% ± 8%), muscle mass (9% ± 8%) and endurance performance (one-legged, 23% ± 15%; whole-body, 8% ± 7%), assessed as weighted combined factors, and were associated with changes in health variables (e.g. visceral fat, -6% ± 21%; [LDL]serum, -4% ± 14%) and muscle tissue characteristics such as fibre type proportions (e.g. IIX, -3%-points), myonuclei.fibre-1 (30% ± 65%), total RNA/rRNA abundances (15%/6-19%), and transcriptome profiles (e.g. ~336 differentially expressed genes). Vitamin D3 supplementation led to robust increases in [25(OH)D]serum (Δ49% vs placebo), but did not affect training-associated changes for any of the main outcome domains, with no interaction being evident with disease status or pre-RCT [25(OH)D]serum. In secondary analyses, vitamin D3 affected expression of gene sets involved in vascular functions in muscle tissue, strength gains in participants with high fat mass, and [cortisol]serum (Δ20%), all of which advocate further study. Conclusions: Vitamin D3 supplementation did not affect muscular responses to resistance training in old adults with or without COPD.

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The Mechanisms of Muscle Mass and Strength Increase during Strength Training

Лысенко

Виноградова

Popov

2021

J Evol Biochem Phys

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Evaluation of training effectiveness for improving maximal voluntary contraction without noticeable hypertrophy of muscles

Cited by 4 publications

References 22 publications

Vitamin D₃supplementation does not enhance the effects of resistance training in older adults

Vitamin D₃supplementation does not enhance the effects of resistance training in older adults

No benefits of prolonged vitamin D₃ supplementation for adaptations to resistance training in old adults

The Mechanisms of Muscle Mass and Strength Increase during Strength Training

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Evaluation of training effectiveness for improving maximal voluntary contraction without noticeable hypertrophy of muscles

Cited by 4 publications

References 22 publications

Vitamin D3supplementation does not enhance the effects of resistance training in older adults

Vitamin D3supplementation does not enhance the effects of resistance training in older adults

No benefits of prolonged vitamin D3 supplementation for adaptations to resistance training in old adults

The Mechanisms of Muscle Mass and Strength Increase during Strength Training

Contact Info

Product

Resources

About

Vitamin D₃supplementation does not enhance the effects of resistance training in older adults

Vitamin D₃supplementation does not enhance the effects of resistance training in older adults

No benefits of prolonged vitamin D₃ supplementation for adaptations to resistance training in old adults