Evaluation of trace metals in follicular fluid in ICSI-treated patients

Wdowiak, Artur; Wdowiak, Edyta; Bojar, Iwona

doi:10.26444/aaem/75422

Cited by 19 publications

(26 citation statements)

References 29 publications

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“…In fact, a study of reproductive age women using a nationally representative 2013–2016 US data set, reported a non-linear dose–response association for blood Hg concentrations and clinical infertility, with a threshold of ∼5.3 µg/l ( Zhu et al , 2020 ). Our results are particularly concerning given that the FF Hg ( Al-Saleh et al , 2008 ; Bloom et al , 2012b ; Tolunay et al , 2016 ) and Pb ( Paksy et al , 2001 ; Silberstein et al , 2004 ; Al-Saleh et al , 2008 ; Bloom et al , 2012b ; Tolunay et al , 2016 ; Wdowiak et al , 2018 ) concentrations in our study population are lower than reported by other studies.…”

Section: Discussioncontrasting

confidence: 73%

Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF

Butts

Bloom

McGough

et al. 2021

Human Reproduction Open

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STUDY QUESTION Are follicular fluid (FF), arsenic (As), mercury (Hg), cadmium (Cd) and lead (Pb) concentrations associated with IVF outcomes among women undergoing IVF? SUMMARY ANSWER There was a non-linear association between higher FF Hg concentration and a lower likelihood of biochemical pregnancy and live birth. Higher FF Pb concentration was also associated with a lower probability of live birth. WHAT IS KNOWN ALREADY Previous research suggests that toxic elements may affect fertility among couples conceiving with and without assistance. However, the results have been inconsistent, possibly related in part to exposure misclassification. Very few studies have used ovarian FF to measure toxic elements, as it requires an invasive collection procedure, yet it may offer a more accurate estimate of a biologically effective dose than blood or urine. STUDY DESIGN, SIZE, DURATION This is a prospective study of 56 women undergoing IVF, from October 2015 to June 2017. FF was collected for analysis on the day of oocyte retrieval. PARTICIPANTS/MATERIALS, SETTING, METHODS As, Cd, Hg and Pb were determined in 197 FF specimens, using inductively coupled plasma tandem mass spectrometry. FF glutathione peroxidase, glutathione reductase, total glutathione-S-transferase, superoxide dismutase, arylesterase and paraoxonase (PON1p) activities were measured using kinetic enzyme assays. MAIN RESULTS AND THE ROLE OF CHANCE Non-linear associations were detected, in which the probabilities of biochemical pregnancy (P = 0.05) and live birth (P = 0.05) were lower in association with FF Hg greater than ∼0.51 µg/l Hg, adjusted for age, race, cigarette smoking and recent seafood consumption. Higher FF Pb was also associated with a lower likelihood of live birth (relative risk (RR) = 0.68, 95% CI: 0.46, 1.00; P = 0.05). We also found a suggestive, although imprecise, antagonizing mediating effect of PON1p activity on the association between FF Pb and live birth (−28.3%; 95% CI: −358%, 270%). LIMITATIONS, REASONS FOR CAUTION The results should be interpreted judiciously given the limited sample size and difficulty accounting for correlated data in generalized additive models and mediation analyses. Additionally, women undergoing IVF are highly selected with respect to age and socioeconomic status, and so the generalizability of the results may be limited. WIDER IMPLICATIONS OF THE FINDINGS Overall, the results suggest that FF Hg was associated with a lower likelihood of biochemical pregnancy and live birth, with a potential threshold effect, and that higher FF Pb was associated with a lower probability of live birth. These results may help to guide clinical recommendations for limiting the exposure of patients to Hg and Pb and ultimately improve IVF success rates. STUDY FUNDING/COMPETING INTEREST(S) This work was funded in part by the National Institute of Environmental Health Sciences (NIEHS), grant number 1R56ES023886-01, to the University at Albany (M.S.B.), and in part by the National Institute of Environmental Health Sciences (NIEHS), grant number 1U2CES026542-01, to the Wadsworth Center (P.J.P.). The authors declare no competing interests. TRIAL REGISTRATION NUMBER N/A

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Section: Discussioncontrasting

confidence: 73%

Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF

Butts

Bloom

McGough

et al. 2021

Human Reproduction Open

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“…Contamination of the environment, especially air, water, and soil with heavy metals such as heavy metals, leads to an increase in heavy metals in food so that the presence of heavy metals in food is therefore inevitable. Plants and plant products, such as bread and cereals, fish and meat, are the most susceptible to contamination, Pb and Cd are the most recognized reproductive toxins human exposure to occupational and environmental pollutants, contributing to adverse effects on chromatin integrity (Wdowiak et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of Heavy Metals Levels In Follicular Fluid on ICSI Outcome

Mohr

Faris

Bakry

et al. 2020

Egyptian Academic Journal of Biological Sciences. C, Physiology

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“…Among the best recognized chemical agents which are attributable to the generation of oxidative stress, are indicated heavy metals, air pollution, plant protection products and tobacco smoke [4,5,6,7]. The physical factors responsible for inducing this phenomenon are electromagnetic fields [8] and ionizing radiation (IR) [9].…”

Section: Introduction and Objectivementioning

confidence: 99%

Effect of ionizing radiation on the female reproductive system

Skrzypek¹,

Wdowiak²,

Panasiuk³

et al. 2019

Ann Agric Environ Med.

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Introduction and objective. The tendency towards postponement of maternity implies a greater exposure of female germ cells to damaging environmental effects, including ionizing radiation (IR). Progress in paediatric oncology, based on the use of radiotherapy, also implies the occurrence of gonadal dysfunctions and subsequent female fertility disorders. Therefore, it seems justifiable to systematize the state of knowledge concerning the effect of IR on the female reproductive system. Brief description of the state of knowledge. A considerable part of studies concerning the effect of IR on female germ cells have been conducted on animals. Their extrapolation to humans is hindered because in animal studies high acute exposures are applied, which do not reflect human environmental exposures characterized by chronic low dose exposure. Studies on animals provide a heterogenous image, which hinders the formulation of unequivocal conclusions and indicates that radiosensitivity depends, i.a. on IR dose, stage of development of oocytes, the applied marker of the effects of IR, or on the species. LD50 of human oocytes is estimated to be below 2 Gy. The effect of IR depends, i.a. on the dose fractionation and the age (older women are more radiosensitive). In females, the effective sterilizing dose is: at birth 20.3 Gy, at 10 years 18.4 Gy, at 20 years 16.5 Gy, whereas at 30 years 14.3 Gy, which is associated with the available pool of ovarian follicles. Conclusions. Within the range of low doses received as a result of environmental exposure to IR, there is no evidence for the occurrence of either adverse pregnancy outcomes, nor fertility disorders in females. These effects may be related to the cancer radiotherapy, or exposure to high IR doses during nuclear accidents.

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Evaluation of trace metals in follicular fluid in ICSI-treated patients

Cited by 19 publications

References 29 publications

Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF

Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF

Effect of Heavy Metals Levels In Follicular Fluid on ICSI Outcome

Effect of ionizing radiation on the female reproductive system

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