Evaluation of Trace Elements and Their Relationship with Growth and Development of Young Children

Cao, Jianming; Gao, Zhiqiang; Yan, Jun; Li, Minming; Jia, Suotang; Xu, Jian; Yan, Chen‐Hua

doi:10.1007/s12011-015-0537-7

Cited by 33 publications

(21 citation statements)

References 15 publications

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“…Intestinal copper absorption occurs very efficiently, and copper excess is removed by the liver and excretion with bile into feces, in the order of 4.5 mg/day [6] . However, most of the copper secreted with the bile is reabsorbed by enterocytes [34,35] , and the copper concentration in Chinese children's blood is around 1 mcg/ml [36] . In addition, the intestinal copper absorption is inversely proportional to the copper content in the diet, being reduced to about one-tenth in high-copper diets [37] .…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Copper Resistance in Aerobic Intestinal Bacteria From Children With Different Levels of Copper-Exposure

Baquero¹,

Sanchez-Valenzuelaa#²,

Ripolla³

et al. 2017

JEHS

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Copper is an environmental element, essential for life, to which humans are exposed by inhalation, hand-to-mouth contamination, or ingestion of food and water. In this work, bacterial copper susceptibility (amount of copper able to inhibit bacterial growth) of aerobic bacteria from the intestinal microbiota of healthy children in Spain was explored. To establish the possible effect of children's exposure to copper in the selection of copper-resistant organisms, the prevalence of copper-resistance among bacteria isolated in stool samples of 233 children belonging to the INMA cohort of the Spanish Project for Environment and Childhood Research was studied. Stool samples were seeded into Szybalsky-type agar plates containing specific culture media and a gradient of copper sulphate (< 0.68 -2.05 mM). Culture media was suitable for growth of Gamma-Proteobacteria (mostly Enterobacteriaceae), Enterococcus and Staphylococcus. Colonies growing at intermediate (IR: < 0.68 -1.36 mM) and/or higher copper concentrations (HR: 1.36 -2.05 mM) were characterized by MaldiTOF assays. Sixty different species of copper-resistant organisms were detected. For Enterobacteriaceae, HR colonies were detected in 64.5% of seeded fecal samples, mostly corresponding to genus Escherichia (77% of positive samples); Enterobacter (15%), Citrobacter (13%), and Klebsiella (4.7%). However, Escherichia coli populations have a significantly lower proportion of high copper resistant colonies (49%) than the ensemble of Klebsiella-Enterobacter-Citrobacter colonies (77%). In HR-colonies of Firmicutes, Enterococcus genus was found in 97.3% of fecal samples, predominantly E. faecium (86%, of the positive Enterococcus samples), E. faecalis (37%), and E. hirae (6.9%). No significant correlation was found between counts of HR-colonies and the copper concentrations found in dry hair of the children studied (10 -30 mcg/g). Copper-resistant populations in the children's intestine might have evolved in the copper-rich external environment.

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Section: Discussionmentioning

confidence: 99%

Phenotypic Copper Resistance in Aerobic Intestinal Bacteria From Children With Different Levels of Copper-Exposure

Baquero¹,

Sanchez-Valenzuelaa#²,

Ripolla³

et al. 2017

JEHS

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“…Micro nutrients include a number of elements which are required in trace amounts to drive critical biochemical processes in the body. These come mainly from intestinal absorption, following oral ingestion [14]. As a result, their metabolism tends to interact either synergistically or antagonistically and this could be important in a number of disease states [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…As a result, their metabolism tends to interact either synergistically or antagonistically and this could be important in a number of disease states [15,16]. This observation is demonstrated in nutritional anemia, in which the intestinal absorption of iron is up regulation along with that of other divalent metals, leading to their altered serum levels [14,17]. It has been observed that micro nutrients such as zinc and copper impair iron absorption and could predispose to the development of anemia [16].…”

Section: Discussionmentioning

confidence: 99%

“…Cao et al determined the influence of iron status and trace element levels on growth and development among children in Shanghai, China and reported that trace elements were significantly related to children's growth and development. The study advocated routine screening and dietary supplementation as potential interventions that could improve growth and development in this population [14]. Zinc has been found to play an important role in the regulation of erythropoiesis, control of iron metabolism and in the modulation of immunity to a num-ber of infectious diseases.…”

Section: Discussionmentioning

confidence: 99%

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Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia

Chide

John

Patrick

et al. 2015

Zahedan J Res Med Sci

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“…Biologically, Zn has three main functions: catalysis, adjustment, and structure. Zn, an enzyme constituent [11,13], also catalyzes enzymatic reactions and plays an important role in metabolism [14,15], tissue respiration [16,17] and regeneration [18,19], and growth [17,20]. Zn may also affect the effectiveness of hormone receptor and target organ responses; hormone production, storage, and secretion; and sexual development [21,22].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Blood Concentrations of Zinc, Germanium, and Lead and Relevant Environmental Factors in a Population Sample from Shandong Province, China

Xu²,

Shao³

et al. 2017

IJERPH

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Trace elements, including zinc (Zn) and germanium (Ge), are essential for health; deficiency or excess levels of trace elements results is harmful. As a result of industrial and agricultural production, Pb widely exists in people’s living environment. It is absorbed mainly through the respiratory and digestive tracts, producing systemic harm. Reference values for a normal, healthy population are necessary for health assessment, prevention and treatment of related diseases, and evaluation of occupational exposures. Reference ranges for the Chinese population have not been established. From March 2009 to February 2010; we collected data and blood samples (n = 1302) from residents aged 6–60 years living in Shandong Province, China. We measured blood concentrations of Zn, Ge, and Pb using inductively coupled plasma mass spectrometry to determine reference ranges. Results were stratified by factors likely to affect the concentrations of these trace elements: sex, use of cosmetics or hair dye, age, alcohol intake, smoking habits, and consumption of fried food. The overall geometric mean (GM) concentrations (95% confidence interval) were 3.14 (3.08–3.20) mg/L for Zn, 19.9 (19.3–20.6) μg/L for Ge, and 24.1 (23.2–25.1) μg/L for Pb. Blood Zn concentrations were higher in women than in men (p < 0.001), while the opposite was found for Pb (p < 0.001) and sex did not influence Ge (p = 0.095). Alcohol use was associated with higher blood concentrations of Zn (p = 0.002), Ge (p = 0.002), and Pb (p = 0.001). The GM concentration of Zn was highest in 20–30-year-olds (p < 0.001), while Pb concentrations were highest in 12–16-year-olds (p < 0.001). Use of hair dye was associated with lower blood concentrations of Ge (p < 0.05). GM blood concentrations of Pb differed significantly between those who consumed fried foods 1–2 times/month (18.7 μg/L), 1–2 times/week (20.9 μg/L), and every day (28.5 μg/L; p < 0.001). Blood Pb concentrations were higher in subjects who used cosmetics (p < 0.05), hair dye (p < 0.05), and who smoked cigarettes (p < 0.001) than in those who did not.

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Evaluation of Trace Elements and Their Relationship with Growth and Development of Young Children

Cited by 33 publications

References 15 publications

Phenotypic Copper Resistance in Aerobic Intestinal Bacteria From Children With Different Levels of Copper-Exposure

Phenotypic Copper Resistance in Aerobic Intestinal Bacteria From Children With Different Levels of Copper-Exposure

Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia

Analysis of Blood Concentrations of Zinc, Germanium, and Lead and Relevant Environmental Factors in a Population Sample from Shandong Province, China

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