Evaluation of Tp‐e Interval, Tp‐e/QT Ratio, and Tp‐e/QTc Ratio in Patients with Asymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy

Alızade, Elnur; Yesi̇n, Mahmut; Yazıcıoğlu, Mehmet Vefik; Karaayvaz, Ekrem Bilal; Atıcı, Adem; Arslan, Şükrü; Avcı, Anıl; Açar, Göksel; Tabakçı, Mehmet Mustafa; İzcı, Servet; Pala, Selçuk

doi:10.1111/anec.12362

Cited by 12 publications

(17 citation statements)

References 38 publications

(56 reference statements)

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“…Inconsistent with our study, Alizade et al (2017) reported for the first time that Inconsistent with our study, Alizade et al (2017) reported for the first time that…”

Section: Ta B L E 2 Electrocardiographic Findings Of the Study Populasupporting

confidence: 89%

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Can abnormal dispersion of ventricular repolarization be a predictor of mortality in arrhythmogenic right ventricular cardiomyopathy: The importance of Tp‐e interval

Çekirdekçi¹,

Buğan²

2018

Noninvasive Electrocardiol

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Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by ventricular arrhythmias and specific ventricular pathology. Repolarization abnormalities, the significant contributor to life‐threatening arrhythmias and mortality, are frequently observed ECG changes in patients with ARVC. This study aimed to evaluate the changes in Tp‐e interval, Tp‐e/QT, Tp‐e/QTc ratio, and traditional electrocardiographic features of electrical dispersion in patients with ARVC. Methods A total of 105 participants were enrolled in the current study. The ARVC group consisted of 40 subjects (30 men, with a median of 35 (26–41) years), and the control group included of 65 age and sex‐matched individuals (42 men, with a median of 37 (24–45) years). The Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were measured by the 12‐lead electrocardiogram. Results Tp‐e interval, cTp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratio were significantly higher in ARVC patients compared to the control group (all p < 0.001). Tp‐e interval, cTp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were significantly increased in deceased ARVC patients compared to the survival group (p = 0.038, p < 0.001, p = 0.006, p = 0.032, respectively). In the multivariate analysis, RV‐FAC and cTp‐e interval level (p < 0.05 for each parameter) were associated with all‐cause mortality [odds ratio 1.747 95% CI (1.012–3.018); p = 0.045 and odds ratio 1.166, 95% CI (1.017–1.336); p = 0.027, respectively]. Conclusion Tp‐e interval, cTp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were prolonged in patients with NC. We revealed that abnormal dispersion of ventricular repolarization suggests the increased risk of mortality in ARVC.

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“…Inconsistent with our study, Alizade et al (2017) reported for the first time that Inconsistent with our study, Alizade et al (2017) reported for the first time that…”

Section: Ta B L E 2 Electrocardiographic Findings Of the Study Populasupporting

confidence: 89%

“…cTp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratios were prolonged in patients with ARVC as compared to healthy subjects. Inconsistent with our study, Alizade et al (2017) reported for the first time that…”

Section: Discussionsupporting

confidence: 77%

Can abnormal dispersion of ventricular repolarization be a predictor of mortality in arrhythmogenic right ventricular cardiomyopathy: The importance of Tp‐e interval

Çekirdekçi¹,

Buğan²

2018

Noninvasive Electrocardiol

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“…In addition, increased Tp-e interval can be used as an indicator of ventricular tachyarrhythmias and cardiovascular mortality. Tp-e/QT ratio, which is a current and new index, has been reported to be a more useful and effective index than QT interval, corrected QT interval and Tp-e interval in determining ventricular repolarization dispersion regardless of heart rate changes [18]. In addition, it was reported that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were significantly prolonged in patients with slow coronary flow compared to patients with normal coronary flow, and these new indices were positively correlated with reduced coronary flow [19].…”

Section: Resultsmentioning

confidence: 99%

Akut Pankreatitli Hastalarda Tp-e Aralığı, Tp-e/QT Oranı and Tp-e/QTc Oranı’nın Değerlendirilmesi

Güler¹,

Öncel²

2020

Acta Medica Alanya

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Amaç: Akut pankreatit etyolojisinden bağımsız olarak kardiyovasküler sistemi etkileyebilir. QT aralığı, düzeltilmiş QT aralığı (QTc), Tp-e aralığı ve Tp-e/QT, Tp-e/QTc oranları gibi elektrokardiyografik parametreler myokardiyal repolarizasyonun değerlendirilmesinde kullanılabilir. Çalışmamızda akut pankreatitin kardiyovasküler sistem üzerine olan etkilerini incelemeyi ve hastalığın ağırlığı ile ventriküler repolarizasyon parametreleri arasındaki ilişkiyi ortaya koymayı amaçladık. Yöntemler: Akut pankreatit tanısı alan hastalarda ventriküler repolarizasyon parametreleri (QT aralığı, QTc aralığı, Tp-e/QT, Tp-e/QTc oranı) kontrol grubu hastaları ile karşılaştırıldı. Ayrıca tüm hastalarda bu parametreler yanında Ranson ve APACHE II skorları ile amilaz değerleri hesaplanarak hastalığın şiddeti ile kardiyak parametreler arasındaki ilişki incelendi. Bulgular: Çalışmada 60 hasta (30 akut pankreatit ve 30 kontrol) incelendi. Tp-e aralığı, Tp-e/QT ve Tp-e/QTc oranlarının akut pankreatitli hastalarda kontrol grubuna göre istatistiksel olarak anlamlı düzeyde daha yüksek olduğu tespit edildi. Ayrıca Tp-e aralığı, Tp-e/QT ve Tp-e/QTc oranlarının Ranson ve APACHE II skorları ile pozitif korelasyon gösterdiği, Tp-e aralığının amilaz düzeyi ile pozitif korelasyon gösterdiği tespit edildi. Sonuç: Akut pankreatitli hastalarda Tp-e aralığı, Tp-e/QT ve Tp-e/QTc oranları ventriküler aritmi riskinin tespitinde kullanılabilir ve Tp-e/QT ve Tp-e/QTc oranlarının yükselmesi akut pankreatitin şiddetiyle doğru orantılı olup, Tp-e oranı amilaz düzeyi ile paralel olarak yükselmektedir. Tek başına amilaz düzeyi akut pankreatitli hastalarda ventriküler aritmi riskinin belirleyicisi olarak kullanılabilir.

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“…Временную гетерогенность реполяризации (глобальную дисперсию реполяризации) оценивали на основе интервала между пиком и окончанием Т-волны -Tpeak -Tend [8; 9]. Моменты начала, пика и окончания Т-волны определяли тангенциальным методом [10], при анализе данных использовали максимальное значение интервала Tpeak -Tend.…”

Section: материалы и методыunclassified

Global changes of ventricular repolarization in arrhythmogenic right ventricular dysplasia

Arteyeva

Земсков

Kurilenko

et al. 2018

Transl. med. (Print)

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РезюмеАктуальность. При аритмогенной дисплазии правого желудочка (АДПЖ) нарушения реполяризации предшествуют структурным изменениям в сердце. Цель работы -оценить изменения желудочковой реполяризации у пациентов с АДПЖ при разной степени выраженности электрокардиографических (ЭКГ) изменений.Материалы и методы. Анализировали стандартные ЭКГ и векторкардиограммы (ВКГ) пациентов НМИЦ им. В. А. Алмазова (n=22, 13 мужчин 51±16 лет и 9 женщин 50±12 лет) с установленным диагнозом АДПЖ. Выраженность ЭКГ изменений оценивали по количеству грудных отведений с отрицательной Т-волной, глобальную дисперсию реполяризации -на основе максимального интервала между пиком и окончанием Т-волны, пространственную последовательность реполяризации -по направлению Т-вектора, длительность потенциалов действия (ДПД) приближенно определяли по величине интервалов Q-Tpeak и Q-Tend.Результаты. При отсутствии инверсии Т-волны в грудных отведениях наиболее поздняя реполяризация имела место в задних областях основания желудочков, при инверсии Т-волны только в правых грудных отведениях -в латеральной части правого желудочка, при инверсии Т-волны во всех грудных отведениях -в передне-верхушечных отделах желудочков. В зависимости от выраженности ЭКГ изменений длительность реполяризации увеличивалась, причем более короткие изначально ДПД увеличивались в большей степени, чем более длинные; глобальная дисперсия реполяризации при этом не возрастала.Заключение. Нарастание ЭКГ изменений реполяризации при АДПЖ -результат неравномерного удлинения ДПД и существенного изменения (вплоть до инверсии) последовательности реполяризации желудочков, не сопровождающегося увеличением глобальной дисперсии реполяризации.Ключевые слова: ЭКГ, ВКГ, Т-волна, аритмогенная дисплазия правого желудочка, длительность потенциалов действия, дисперсия реполяризации.Для цитирования: Артеева Н.В., Земсков И.А., Куриленко Т.А., Пармон Е.В. глобальные изменения желудочковой реполяризации при аритмогенной дисплазии правого желудочка. Трансляционная медицина. 2018;5(4): 35-43 .

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Evaluation of Tp‐e Interval, Tp‐e/QT Ratio, and Tp‐e/QTc Ratio in Patients with Asymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy

Cited by 12 publications

References 38 publications

Can abnormal dispersion of ventricular repolarization be a predictor of mortality in arrhythmogenic right ventricular cardiomyopathy: The importance of Tp‐e interval

Can abnormal dispersion of ventricular repolarization be a predictor of mortality in arrhythmogenic right ventricular cardiomyopathy: The importance of Tp‐e interval

Akut Pankreatitli Hastalarda Tp-e Aralığı, Tp-e/QT Oranı and Tp-e/QTc Oranı’nın Değerlendirilmesi

Global changes of ventricular repolarization in arrhythmogenic right ventricular dysplasia

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