Evaluation of Tp-e interval, Tp-e/QT ratio and index of cardiac-electrophysiological balance in patients with tinnitus

Kaya, Hakan; Süner, Arif; Koparal, Mehtap; Yücetaş, Şeyho Cem; Kafadar, Safiye

doi:10.1186/s12872-021-02227-8

Cited by 8 publications

(6 citation statements)

References 33 publications

(29 reference statements)

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“…There are few studies on ICEB in the literature. ICEB value is increased in cardiac diseases such as increased pericardial volume or acute myocarditis with arrhythmia and non-cardiac diseases such as rheumatoid arthritis, tinnitus, and endstage renal disease [22][23][24][25][26]. Our study observed that the ICEB and ICEBc values were significantly high in aneurysmal SAH patients.…”

Section: Discussionsupporting

confidence: 46%

Evaluation of index of cardiac-electrophysiological balance in patients with subarachnoid hemorrhage

Yücetaş

Kaya

Kafadar

et al. 2022

BMC Cardiovasc Disord

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Background Various electrocardiographic (ECG) changes occur after subarachnoid hemorrhage (SAH). Prolonged QT and corrected QT (QTc) intervals are notable changes. QT, QTc, T peak-to-end T(p-e) intervals, and Tp-e/QTc ratio are used as ventricular arrhythmia indices. In recent publications, the cardiac electrophysiological balance index (ICEB), which provides more information than other ECG parameters (QT, QTc, etc.), is recommended in predicting the risk of ventricular arrhythmia. This study aims to assess ICEB in aneurysmal SAH patients. Methods The study included 50 patients diagnosed with aneurysmal SAH and 50 patients diagnosed with hypertension without end-organ damage as the control group. All patients’ Fisher scores and Glasgow Coma Scale (GCS) scores were recorded. Both groups were given 12-lead ECGs. QT, QTc, Tp-e intervals, QRS duration, ICEB (QT/QRS), ICEBc (QTc/QRS), and T(p-e)/QTc values were calculated and analyzed between groups. Results Compared to the control group; QT (426,64 ± 14,62 vs. 348,84 ± 12,24 ms, p < 0,001), QTc (456,24 ± 28,84 vs. 392,48 ± 14,36 ms, p < 0,001), Tp-e (84,32 ± 3,46 vs. 70,12 ± 3,12, p < 0,001), Tp-e/QTc (0,185 ± 0,08 vs. 0,178 ± 0,02, p < 0,001), ICEB (4,53 ± 0,78 vs. 3,74 ± 0,28, p < 0,001) and ICEBc (4,86 ± 0,86 vs. 4,21 ± 0,24, p < 0,001) were significantly higher in patients with aneurysmal SAH. QT, QTc and Tp-e interval, Tp-e/QTc ratio, ICEB (QT/QRS) and ICEBc (QTc/QRS) were positively correlated with the Fisher score and were negatively correlated with the GCS. According to linear regression analyses, the ICEBc (QTc/QRS) found to be independently associated with the Fisher score. Conclusion The values of the ICEB and ICEBc were significantly increased in patients with aneurysmal SAH. The severity of SAH was positively correlated with the ICEB and ICEBc. The ICEBc (QTc/QRS) independently associated with the Fisher score. This may that SAH suggest may predispose to malignant ventricular arrhythmias.

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Section: Discussionsupporting

confidence: 46%

Evaluation of index of cardiac-electrophysiological balance in patients with subarachnoid hemorrhage

Yücetaş

Kaya

Kafadar

et al. 2022

BMC Cardiovasc Disord

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“…In addition, depression has been researched more intensively due to its relationship with events like sudden cardiac arrest due to malignant cardiac arrhythmia [ 32 ]. Changes in cardiac autonomic neural tone and high sympathetic activity in the ventricular myocardium are linked with total repolarization distribution and increased arrhythmia risk [ 33 ]. Cardiovascular autonomic dysfunction, sympathetic dominance, and parasympathetic withdrawal are frequently proposed mechanisms linking arrhythmia risk to psychological distress.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of frontal QRS-T angle values in electrocardiography in patients with chronic rhinosinusitis

Abuş

Koparal

Kaya

et al. 2023

BMC Cardiovasc Disord

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Background Chronic Rhinosinusitis (CRS) refers to inflammation of the paranasal sinuses and nasal mucosa. Electrocardiographic indicators of ventricular repolarization have been shown to correlate with systemic inflammation parameters. Recently, the frontal QRS-T (fQRS-T) angle has been accepted as a new indicator of ventricular depolarization and repolarization heterogeneity. The (fQRS-T) angle is recommended in predicting the risk of malignant ventricular arrhythmia. In this study, we aimed to evaluate the ventricular arrhythmia potential in patients with chronic rhinosinusitis by examining the relationship between fQRS-T angle on ECG and inflammation markers. Methods Inflammatory markers as well as electrocardiographc (ECG) f(QRS-T) angle, QRS duration, QT interval and corrected QT interval were examined in 54 patients with CRS versus 56 healthy control subjects. Results The f(QRS-T) angle was significantly higher in CRS patients than in healthy controls (p < .001). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) were significantly higher in CRS patients compared to healthy controls (p < .001, for all). Based on correlation analysis, NLR and f(QRS-T) angles were highly correlated (r = .845, p < .001), and according to the results of linear regression analysis, NLR was independently associated with the f(QRS-T) angle (t = 5.149, Beta = 0.595, p = < 0.001). Conclusion Both f(QRS-T) angle and NLR are significantly increased in CRS patients compared to healthy controls, with increases in NLR also independently associating with increases in f(QRS-T) angle. While the increases in f(QRS-T) angle did not result in clinically alarming absolute values for f(QRS-T), CRS patients might nonetheless be at relatively higher risk for malignant cardiac arrhythmias.

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“…One study showed that iCEB and iCEBc were elevated after hemodialysis (iCEB: 4.38 ± 0.76 vs. 4.02 ± 0.73, P = 0.016; iCEBc: 4.91 ± 0.73 vs. 4.42 ± 0.80, P = 0.006), but there was no significant change in the QT interval or QTc, indicating that the new ECG marker was more sensitive to cardiac electrophysiological balance ( 22 ). However, in some studies, differences in iCEB were often explained by differences in QTc or QRS duration ( 12 , 23 ). In fact, no study has directly linked iCEBc to cardiac or all-cause death.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of index of cardiac electrophysiological balance among US middle-aged adults

Chen

Wang

Liu

et al. 2023

Front. Cardiovasc. Med.

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BackgroundIndex of cardiac electrophysiological balance (iCEB) has been widely used in clinical practice but no studies investigated the association between iCEB and prognosis in the general population.ObjectiveTo assess the correlation between the iCEB and the prognosis in the general population.MethodsThis retrospective cohort study involved adults aged 40–65 years who participated in the Third National Health and Nutrition Examination Survey (NHANES-III) and whose electrocardiograms were in sinus rhythm. The corrected iCEB (iCEBc) was the ratio of corrected QT interval (QTc) to QRS duration, and outcomes were cardiac and all-cause mortality. Cox proportional hazards regression model was used to identify the associations of iCEBc with end point. The value of iCEBc for predicting adverse events was evaluated by reclassification and discrimination analyses.ResultsAmong 5,010 participants (mean age 51.10 ± 7.67 years, 52.5% female), 3,454 (68.9%) were Non-Hispanic White. The mean iCEBc was 4.45 ± 0.56. A total of 2,147 deaths were recorded during a median follow-up of 319 months. The adjusted model shown iCEBc was an independent risk factor for all-cause death. The iCEBc was linearly correlated with all-cause mortality and the optimal cutoff value was 4.57 in males and 4.98 in females. In the resultant model, prolonged iCEBc remained independently associated with a higher rate of mortality (HR: 1.25; 95% CI: 1.11–1.42) and cardiac death (HR: 1.34; 95% CI: 1.04–1.71). Among the complete study population or the group with normal QTc interval, the performance of the predictive model after addition of iCEBc was not weaker than the model after the addition of prolonged QTc.ConclusionElevated iCEBc (male ≥4.57 and female ≥4.98) is an independent risk factor for cardiac or all-cause death among the middle-age adults. The clinical application value of iCEBc is firmly based on basic physiological principles and its application deserves further attention.

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Evaluation of Tp-e interval, Tp-e/QT ratio and index of cardiac-electrophysiological balance in patients with tinnitus

Cited by 8 publications

References 33 publications

Evaluation of index of cardiac-electrophysiological balance in patients with subarachnoid hemorrhage

Evaluation of index of cardiac-electrophysiological balance in patients with subarachnoid hemorrhage

Evaluation of frontal QRS-T angle values in electrocardiography in patients with chronic rhinosinusitis

Prognostic value of index of cardiac electrophysiological balance among US middle-aged adults

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