Evaluation of toxicological profile of methanol leaf extract of Waltheria indica (Sterculiaceae)

Abstract

Waltheria indica has been claimed to be used in managing several diseases in traditional medicine, although substantial scientific data are not available as regards its safety despite its pronounced efficacy in management of some ailments. Therefore, methanol leaf extract of W. indica was evaluated for its effects on some toxicological parameters using experimental animals. However, acute and sub-acute toxicity were carried out using experimental animals as described by standard methods. Absence of death reported after 24 hours of single oral administration of W. indica indicated that the crude drug is safe orally and the sample also had no effect on both hematological and biochemical parameters, with mild toxicity observed with some vital enzymes and organs upon continuous oral administration of W. indica for 21 days. However, it can be concluded that prolong usage of the plant for disease management should be discouraged, which implies that usage of the pant for short time usage in disease management.

Celosia trigyna Linn (Cucurbitaceae) Annihilate Human Breast, Colon, and Lung Cancer Cells: Combination of Cheap Template for Anticancer Screening

“…The radical scavenging activity of the CT and CTA was carried out against 2, 2 1 -Diphenyl-1-picryl hydrazyl radical (DPPH, Sigma-Aldrich) using a method described by [31][32][33]. About 20-100 µg/mL of test samples and vitamin C were prepared in methanol (Analar grade).…”