Evaluation of Toxicity of Nanoparticles Using Cell Lines

Silica nanoparticles-induced cytotoxicity and genotoxicity in A549 cell lines

“…SiO 2 NPs have been demonstrated to induce adverse signaling in a range of cells, including endothelial cells, macrophages, and lung cancerous cells, thereby establishing common pathways and activating stress responses 20 . In the field of nanotoxicology, initial screening of nanoparticle toxicology research typically employs laboratory evaluation methods using cell cultures 21 . Various in vitro assays, such as cell viability assessments, oxidative stress assays, and particle size analyses, are utilized to evaluate nanoparticles' effects on cells 22 .…”