Evaluation of Total Flavonoids, Myricetin, and Quercetin from Hovenia dulcis Thunb. As Inhibitors of α-Amylase and α-Glucosidase

Meng, Yan; Su, Anping; Yuan, Shuai; Zhao, Huaguo; Tan, Siyuan; Hu, Chen; Deng, Hong; Guo, Yurong

doi:10.1007/s11130-016-0581-2

Cited by 121 publications

(78 citation statements)

References 16 publications

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“…One of the most widely used and widely distributed flavonols in human nutrition with reported anti-diabetic and anti-inflammatory activity is quercetin (Vinayagam and Xu, 2015; Li et al, 2016). Several mechanisms of its action include inhibition of intestinal glucose absorption by inhibition of GLUT2 (Kwon et al, 2007), decrease of lipid peroxidation (Coskun et al, 2005), inhibition of α-amylase and α-glucosidase (Meng et al, 2016). With the rapid increase of diabetes incidence, a need for effective phytochemicals with anti-diabetic activity rises.…”

Section: Herbal Products and Secondary Metabolitesmentioning

confidence: 99%

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

2017

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Diabetes mellitus is a common effect of uncontrolled high blood sugar and it is associated with long-term damage, dysfunction, and failure of various organs. In the adult population, the global prevalence of diabetes has nearly doubled since 1980. Without effective prevention and management programs, the continuing significant rise in diabetes will have grave consequences on the health and lifespan of the world population, and also on the world economy. Supplements can be used to correct nutritional deficiencies or to maintain an adequate intake of certain nutrients. These are often used as treatments for diabetes, sometimes because they have lower costs, or are more accessible or “natural” compared to prescribed medications. Several vitamins, minerals, botanicals, and secondary metabolites have been reported to elicit beneficial effects in hypoglycemic actions in vivo and in vitro; however, the data remain conflicting. Many pharmaceuticals commonly used today are structurally derived from natural compounds from traditional medicinal plants. Botanicals that are most frequently used to help manage blood glucose include: bitter melon (Momordica charantia), fenugreek (Trigonella foenum graecum), gurmar (Gymnema sylvestre), ivy gourd (Coccinia indica), nopal (Opuntia spp.), ginseng, Russian tarragon (Artemisia dracunculus), cinnamon (Cinnamomum cassia), psyllium (Plantago ovata), and garlic (Allium sativum). In majority of the herbal products and secondary metabolites used in treating diabetes, the mechanisms of action involve regulation of insulin signaling pathways, translocation of GLUT-4 receptor and/or activation the PPARγ. Several flavonoids inhibit glucose absorption by inhibiting intestinal α-amylase and α-glucosidase. In-depth studies to validate the efficacies and safeties of extracts of these traditional medicinal plants are needed, and large, well designed, clinical studies need to be carried out before the use of such preparations can be recommended for treatment and/or prevention of diabetes. The main focus of this review is to describe what we know to date of the active compounds in these, along with their glucose-lowering mechanisms, which are either through insulin-mimicking activity or enhanced glucose uptake.

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Section: Herbal Products and Secondary Metabolitesmentioning

confidence: 99%

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

2017

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“…It can promote digestion, produce saliva, quench thirst, antifebrile, and relieve hangovers [6]. Previous results indicated that both polyphenolics and polysaccharides obtained from H. dulcis exhibit a variety of bioactivities, such as antioxidant activities [4,[7][8][9][10], hypoglycemic activities [10,11], and immunostimulatory activity [12]. In addition, natural polyphenolic-protein-polysaccharide complexes (PPPs) extracted from the peduncle of H. dulcis have also been proved to exhibit strong in vitro antioxidant activity, anti-glycation activity, and anti-hyperglycemic effects [6].…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic-Protein-Polysaccharide Complexes from Hovenia dulcis: Insights into Extraction Methods on Their Physicochemical Properties and In Vitro Bioactivities

Xian

et al. 2020

Foods

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Seven extraction methods, including hot water extraction (HWE), pressurized water extraction (PWE), ultrasound-assisted extraction, microwave-assisted extraction, ultrasound-assisted enzymatic extraction, high-speed shearing homogenization extraction, and ultrasound-microwave-assisted extraction, were utilized to extract polyphenolic-protein-polysaccharide complexes (PPPs) from Hovenia dulcis. Next, their physicochemical properties and in vitro antioxidant activities, antiglycation effects, and inhibition activities on α-glucosidase and α-amylase were studied and compared. The findings from this study indicate that various extraction processes exhibit notable influences on the physicochemical properties and in vitro bioactivities of PPPs. Extraction yields, contents of polyphenolics and flavonoids, apparent viscosities, molecular weights, molar ratios of monosaccharide compositions, and ratios of amino acid compositions in PPPs varied in different extraction methods. Furthermore, 13 phenolic compounds in PPPs, including rutin, myricitrin, myricetin, quercetin, kaempferol, protocatechuic acid, gallocatechin, p-hydroxybenzoic acid, ampelopsin, quercetin-7,4′-diglucoside, dihydroquercetin, 5-methylmyricetin, and naringenin, were identified. The relatively strong in vitro antioxidant activities, antiglycation effects, and inhibition activities on α-glucosidase and α-amylase were determined in both PPP-W and PPP-P obtained by HWE and PWE, respectively. The high content of total polyphenolics may be one of the main contributors to their in vitro bioactivities. The findings have shown that the PWE method can be an appropriate method to prepare PPPs with strong bioactivities for application in the functional food industry.

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“…All of the flavonoids have less activity than the positive standard, acarbose, which is a complex oligosaccharidean, an inhibitor of α‐glucosidase that delays the digestion of ingested carbohydrates in the small intestine and hence reduces the increase in blood‐glucose concentrations after a carbohydrate load together with diarrhoea and other digestive problems due to its strong inhibitory activity on α‐amylase (IC50 = 0.011 mg mL −1 ). In Tadera's report (), quercetin has an IC 50 of 0.5 m m and the inhibition of kaempferol is 18% at 0.5 m m ; Meng's report () indicated that the IC 50 of quercetin was 770 μg mL −1 (approximately 2.55 m m ). These reports show the activity of flavonoids, but the strength is not consistent or comparable due to the different reaction systems and sources of α‐amylase.…”

Section: Resultsmentioning

confidence: 86%

In vitro potential of flavonoids from tartary buckwheat on antioxidants activity and starch digestibility

Peng

Wei

Qian

et al. 2019

Int J of Food Sci Tech

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Summary The effects of various flavonoids of Tartary buckwheat (rutin‐enhanced flavonoid extract [REFE and quercetin‐enhanced flavonoid extract [QEFE]) and individual flavonoids (rutin, quercetin and kaempferol) on the antioxidant activity, inhibition of α‐glucosidases and α‐amylase and starch digestibility were evaluated. Quercetin possessed the highest antioxidant activity and inhibition of α‐glucosidases and α‐amylase activity followed by kaempferol and rutin. REFE and QEFE have similar antioxidant and inhibition of α‐amylase activities, but QEFE has much higher α‐glucosidases inhibition than REFE. Tartary buckwheat flour has the lowest content of rapidly digestible starch and predicted glycaemic index (pGI) compared to maize flour, wheat flour and rice flour. Addition of rutin and quercetin to wheat flour showed a weak or no effect on digestion inhibition, but they inhibited starch digestion under solid complex conditions. Our results may help explain the benefits of supplementing the diet with food rich in flavonoids.

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Evaluation of Total Flavonoids, Myricetin, and Quercetin from Hovenia dulcis Thunb. As Inhibitors of α-Amylase and α-Glucosidase

Cited by 121 publications

References 16 publications

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes

Polyphenolic-Protein-Polysaccharide Complexes from Hovenia dulcis: Insights into Extraction Methods on Their Physicochemical Properties and In Vitro Bioactivities

In vitro potential of flavonoids from tartary buckwheat on antioxidants activity and starch digestibility

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