Evaluation of topicalMatricaria chamomillaextract activity on linear incisional wound healing in albino rats

Abstract

In this investigation, the effect of Matricaria chamomilla extract on linear incisional wound healing was studied. Thirty male Wistar rats were subjected to a linear 3 cm incision made over the skin of the back. The animals were randomly divided into three experimental groups, as control, olive oil, and treatment. Control group did not receive any drug or cold cream. Olive oil group received topical olive oil once a day from beginning of experiments to complete wound closure. Treatment group were treated topically by M. chamomilla extract dissolved in olive oil at the same time. For computing the percentage of wound healing, the area of the wound measured at the beginning of experiments and the next 2, 5, 8, 11, 14, 17, and 20 days. The percentage of wound healing was calculated by Walker formula after measurement of the wound area. Results showed that there were statistically significant differences between treatment and olive oil animals (p < 0.05) in most of the days. We conclude that the extract of M. chamomilla administered topically has wound healing potential in linear incisional wound model in rats.

Wound healing activity of topical phenytoin in excision wound model of Albino rats

“…The results of days required for epithelialization of Phenytoin 1% and 10% of my study were in contrast to studies done by Hasamnis AA et al, Jarrahi M et al, Qunaibi EA et al 1,2,6 Collagen is a major protein of extracellular matrix and is the component that ultimately contributes to wound strength. Breakdown of collagen fibres liberates free hydroxyproline and its peptide.…”

“…5 Previous animal studies have been done for evaluating wound healing effect of topical Phenytoin on Excision and Incision wound models using 1% Phenytoin and 10% Phenytoin. 1,2,6 Only few studies includes detailed histological and biochemical assessment of Phenytoin on wound healing. Hence present study was undertaken to evaluate the effect of topical Phenytoin on excision wound models using three different concentrations of Phenytoin and assessment of biochemical parameter.…”

The Effect of Chamomile Cream on Episiotomy Pain in Primiparous Women: A Randomized Clinical Trial

“…Currently, finding the most effective method with minimal complications, availability and easily acceptance by women has always been considered by researchers. 15 …”

“…15 Episiotomy pain often caused by inflammation and edema. 6 Due to the strong anti-inflammatory effect of chamomile which has been mentioned in several studies, 15,16-22 , it seems that chamomile could be used as a pain killer by reducing edema and inflammation in the first days after delivery. 16 In addition to the mechanisms in inhibiting the prostaglandin synthesis in reducing pain, other painless mechanisms are also possible.…”

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

“…Graph paper was used to record and measure the wound areas, and the Walker formula was utilized for assessing the ratio of wound healing. 7 Wound healing rate ð%Þ ¼ 100 3ð1 À wound area=initial wound areaÞ…”