Evaluation of titanium-prepared platelet-rich fibrin and leucocyteplatelet-rich fibrin in the treatment of intra-bony defects: Arandomized clinical trial

Gummaluri, Shiva Shankar; Bhattacharya, Hirak S; Astekar, Madhusudan; Cheruvu, Shivani

doi:10.34172/joddd.2020.020

Cited by 15 publications

(25 citation statements)

References 37 publications

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“…T-PRF can be utilized as autogenous material as a substitute for connective-tissue graft (CTG), a recognized gold standard for root coverage [29]. T-PRF improved clinical metrics, suggesting that they may help in the restoration of soft tissue in intrabony lesions [30]. When combined with open flap debridement (OFD), the use of T-PRF membranes leads to a significant release of the greater number of growth factor concentrations and a lower number of 'RANKL/OPG ratio' in GCF [31].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Shirbhate¹,

Bajaj²

2022

Cureus

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Platelets are important for hemostasis and the healing of wounds. In clinical settings, healing cytokines including insulin-like growth factors (IGF), platelet-derived growth factors (PDGF), and transforming growth factors (TGF) are commonly implemented. The regenerative approach in dentistry frequently employs platelet concentrates (PCs) that are "autologous in origin" and have a high concentration of platelets, growth factors, and leukocytes. First-generation PCs is made of platelet-rich plasma (PRP), while secondgeneration PC is made of platelet-rich fibrin (PRF). Both have limitations, so modification protocols and development in PRP and PRF derivatives are required for advancement mechanisms, strength, biodegradability, retention ability in the field of regenerative dentistry, and so on. As third-generation PC, newer genera kinds of PRF, such as advanced-PRF (A-PRF), advanced-PRF+ (A-PRF+), injectable-PRF (i-PRF), and titanium-PRF (T-PRF), were introduced. A-PRF matrices in their solid form were introduced using the low-speed centrifugation concept (LSCC). The applied relative centrifugal force (RCF) for A-PRF is reduced to 208 g as a result of this improved preparation process. A-PRF features a greater number of neutrophil granules in the distal region, especially at the red blood cells-buffer coat (RBC-BC) interface, and the A-PRF clot has a more porosity-like structure with a bigger interfibrous space than PRF. Since the PRF is in a gel form and is difficult to inject, i-PRF was formulated to address this problem. Compared to the other two protocols, the i-PRF protocol requires far less time, and this is the advantage of this PC. This is because i-PRF just needs the blood components to be separated, which happens within the first two to four minutes. Compared to normal L-PRF, T-PRF creates fibrin that is thicker and more densely woven. Titanium has a higher hemocompatibility than glass, which could lead to greater polymerized fibrin formation. In periodontal regenerative operations, oral surgery, and implant dentistry, PRF and its newer advanced modifications have demonstrated promising results and desirable results in both soft and hard tissue regenerative techniques.

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Section: Clinical Applicationsmentioning

confidence: 99%

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Shirbhate¹,

Bajaj²

2022

Cureus

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“…[ 20 ] PRF and T-PRF were compared in three studies. [ 19 21 22 ] In one study, the outcomes measured were PPD, CAL, PI, and bone defect depth reduction. The risk of bias was found low for this study.…”

Section: Resultsmentioning

confidence: 99%

“…T-PRF group displayed significantly greater defect fill compared with L-PRF, although other parameters were not significantly different. [ 19 ]…”

Section: Resultsmentioning

confidence: 99%

“…Among the selected seven RCTs, Three studies compared the regenerative potential of PRP and PRF (OFD + PRF/PRP versus OFD). [ 17 18 23 ] Two studies reported the comparison of PRF and T-PRF (OFD + PRF versus OFD + T-PRF)[ 20 21 ] and only one study reported the comparison of PRF and L-PRF (OFD + PRF vs. OFD + L-PRF)[ 19 ] and PRF and PRGF along with xenograft (OFD + xenograft + PRF/PRGF)[ 20 ] with respect to periodontal osseous defect management. Overall analysis of the results of the included studies revealed that irrespective of the type of platelet concentrates used, there was a significant improvement in the outcome parameters as compared to baseline in all the studies.…”

Section: Discussionmentioning

confidence: 99%

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Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management

Reshma

Varghese

Pampadykandathil

2022

Journal of Indian Society of Periodontology

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This systematic review aims to compare the regenerative potential of different preparations of platelet concentrates in periodontal osseous defect regeneration. A comprehensive search was conducted on PubMed, Cochrane, and Medline electronic databases including articles published till April 2020. Search was performed as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Of the total 224 studies fetched for the study, 7 were found relevant and included. Studies with a follow-up period of <6 months or those reporting periodontal intrabony defects that apically extended with endodontic involvements were excluded. Two studies reported no significant differences in outcomes between platelet-rich fibrin (PRF) and platelet-rich plasma (PRP), whereas one study reported a slightly superior effect of PRF over PRP. Titanium PRF (T-PRF) displayed significantly greater defect fill compared with leukocyte-rich–platelet-rich fibrin in one study, although other parameters were not significantly different. plasma rich in growth factors (PRGFs) and PRF show similar improvements in the outcomes. Furthermore, comparison between PRF and T-PRF did not show statistically significant differences in the two included studies. The results of the present systematic review indicate no significant differences in outcome between different platelet concentrates in the management of periodontal osseous defects. Limited evidences favor PRF over PRP and T-PRF over PRF. However, additional powered studies with much larger sample sizes are needed to obtain a more concrete conclusion.

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“…On the comparative evaluation of T-PRF and L-PRF as better alternatives for the treatment of intrabony defects, T-PRF was suggested to be a better option. However, soft tissue healing was similar in both [ 54 ].…”

Section: Autologous Materials As Regenerative Substitutes For Periodo...mentioning

confidence: 99%

Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review

Varghese

Rajagopal

2022

Polymers

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Periodontal infections are noncommunicable chronic inflammatory diseases of multifactorial origin that can induce destruction of both soft and hard tissues of the periodontium. The standard remedial modalities for periodontal regeneration include nonsurgical followed by surgical therapy with the adjunctive use of various biomaterials to achieve restoration of the lost tissues. Lately, there has been substantial development in the field of biomaterial, which includes the sole or combined use of osseous grafts, barrier membranes, growth factors and autogenic substitutes to achieve tissue and bone regeneration. Of these, bone replacement grafts have been widely explored for their osteogenic potential with varied outcomes. Osseous grafts are derived from either human, bovine or synthetic sources. Though the biologic response from autogenic biomaterials may be better, the use of bone replacement synthetic substitutes could be practical for clinical practice. This comprehensive review focuses initially on bone graft replacement substitutes, namely ceramic-based (calcium phosphate derivatives, bioactive glass) and autologous platelet concentrates, which assist in alveolar bone regeneration. Further literature compilations emphasize the innovations of biomaterials used as bone substitutes, barrier membranes and complex scaffold fabrication techniques that can mimic the histologically vital tissues required for the regeneration of periodontal apparatus.

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Evaluation of titanium-prepared platelet-rich fibrin and leucocyteplatelet-rich fibrin in the treatment of intra-bony defects: Arandomized clinical trial

Cited by 15 publications

References 37 publications

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management

Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review

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