Evaluation of tissue reaction to freshly mixed endodontic sealers and their relationship with the M1 macrophage phenotype

Abstract

Introduction: This study assessed tissue response to freshly mixed sealers (Sealer 26 -SE26 and Epiphany -EPH) and the relationship between M1 macrophages and tissue repair. Methods: A total of 21 rats were used to assess tissue response at 7, 14 and 21 days post-implantation. Half of histopathological sections were labeled with anti-iNOS antibodies (M1 macrophage subset) and half were graded according to the inflammatory intensity. Results: On day 7, no significant difference was found in the intensity of the

The Effect of Branched Alkyl Chain Length on the Properties of Supramolecular Organogels from Mono-N-Alkylated Primary Oxalamides

“…Mast cells are immune cells that originate from bone marrow progenitor cells before circulating in the blood steam and then migrating into the tissues where they regulate vasodilation, vascular homeostasis, immune responses, angiogenesis and venom detoxification [80,81]. As key effector cells in allergic inflamma-tion and adverse drug reactions, mast cells are frequently activated in patients that have hypersensitivity reactions to medications or implant materials [82][83][84]. The BMMCs used in this study were cultured from wild type mice and do not harbor any known mutations, displaying normal senescent properties consistent with healthy primary cells.…”