Evaluation of time to positivity for blood culture combined with immature granulocytes, neutrophil‐to‐lymphocyte ratio, and CRP in identifying bloodstream coagulase‐negative <i>Staphylococci</i> infection in pediatric patients

Zeng, Ling‐Li; Wang, Shuhui; Lin, Minchun; Chen, Yaxing; Deng, Qiulian; Zhong, Huamin; Guan, Xiaoshan; Yao, Shuwen; Liu, Haiying

doi:10.1002/jcla.23473

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…S. hominis is a coagulase-negative member of the genus Staphylococuss (CoNS). They are commonly encountered blood culture contaminants whose contamination rate is reported to be over 44%[ 16 , 17 ]. On the other hand, they also constitute an important cause of blood stream infection in the ever-expanding population of patients with biomedical devices, broad-spectrum antibiotics and indwelling catheters[ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…They are commonly encountered blood culture contaminants whose contamination rate is reported to be over 44%[ 16 , 17 ]. On the other hand, they also constitute an important cause of blood stream infection in the ever-expanding population of patients with biomedical devices, broad-spectrum antibiotics and indwelling catheters[ 16 , 17 ]. Thus, the isolation of CoNS from blood cultures remains a clinical dilemma in many cases, and it is difficult to determine with certainty the clinical significance of these isolates[ 18 ].…”

Section: Discussionmentioning

confidence: 99%

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Spinal epidural abscess due to coinfection of bacteria and tuberculosis: A case report

Kim¹,

Lee²,

Kim³

2021

WJCC

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BACKGROUND Spinal epidural abscess (SEA) is a rare condition that mostly results from infection with either bacteria or tuberculosis. However, coinfection with bacteria and tuberculosis is extremely rare, and it results in delays in diagnosis and antimicrobial treatment causing unfavorable outcomes. CASE SUMMARY A 75-year-old female visited the hospital with low back pain, and magnetic resonance imaging (MRI) revealed an SEA at the lumbosacral segment. Staphylococcus hominis and methicillin-resistant Staphylococcus epidermidis were identified from preoperative blood culture and intraoperative abscess culture, respectively. Thus, the patient underwent treatment with vancomycin medication for 9 wk after surgical drainage of the SEA. However, the low back pain recurred 2 wk after vancomycin treatment. MRI revealed an aggravated SEA in the same area in addition to erosive destruction of vertebral bodies. Second surgery was performed for SEA removal and spinal instrumentation. The microbiological study and pathological examination confirmed Mycobacterium tuberculosis as the pathogen concurrent with the bacterial SEA. The patient improved completely after 12 mo of antitubercular medication. CONCLUSION We believe that the identification of a certain pathogen in SEAs does not exclude coinfection with other pathogens. Tubercular coinfection should be suspected if an SEA does not improve despite appropriate antibiotics for the identified pathogen.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spinal epidural abscess due to coinfection of bacteria and tuberculosis: A case report

Kim¹,

Lee²,

Kim³

2021

WJCC

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“…They may include promyelocyte, myelocyte, and metamyelocyte cells. In healthy individuals, IGs are not typically released into blood circulation [6][7][8]. However, infection or inflammation can cause the release of IG to peripheral blood [6,7].…”

mentioning

confidence: 99%

“…In healthy individuals, IGs are not typically released into blood circulation [6][7][8]. However, infection or inflammation can cause the release of IG to peripheral blood [6,7]. Therefore, IGs can be used as inflammatory parameter or an indicator of the severity of infection [6,7].…”

mentioning

confidence: 99%

“…However, infection or inflammation can cause the release of IG to peripheral blood [6,7]. Therefore, IGs can be used as inflammatory parameter or an indicator of the severity of infection [6,7]. The development of new automated hematology analyzers has facilitated the easy identification of IGs, in contrast to a time-consuming manual platelet count peripheral blood smear [9].…”

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confidence: 99%

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Predictive values of immature granulocyte and other inflammatory parameters on disease severity of COVID‐19 patients

alisik¹

2021

Int J Med Biochem

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Predictive value of immature granulocyte count and other inflammatory parameters for disease severity in COVID-19 patients C oronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection, was declared a pandemic by the World Health Organization in March 2020 [1]. Since the first case, identified in late 2019, COVID-19 has affected over 145.2 million people around the world and caused more than 3.08 million deaths as of April 24, 2021 [2]. COVID-19 infection may be asymptomatic or have clinical manifestations that range from mild to severe, but understanding the signs upon presentation remains complex [3]. Greater disease severity is associated with poor outcomes and Objectives: This study was designed to compare the immature granulocyte (IG) count, IG-to-lymphocyte ratio (IGLR), complete blood count (CBC) values, and inflammatory parameters of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), ferritin level, and CRP-to-albumin ratio (CAR) measured at hospital admission in patients with coronavirus disease 2019 (COVID-19) and non-COVID-19 patients and to compare these parameters between subgroups according to disease severity. In addition, these parameters were evaluated for predictive value related to the severity of COVID-19. Methods: The data of adult patients admitted with a suspected COVID-19 infection confirmed with real-time polymerase chain reaction testing of nasal and pharyngeal swab specimens were included in this retrospective study. Outpatient COVID-19-positive patients were enrolled in the mild group, hospitalized patients were classified in the moderate group, and patients admitted to the intensive care unit were categorized in the severe group. Results: A total of 1213 COVID-19-positive patients and 1034 COVID-19-negative patients were included in the study. The IGLR, NLR, PLR, CRP, CAR, and ferritin levels were significantly higher, and the leukocyte, IG, neutrophil, lymphocyte, monocyte, basophil, and eosinophil levels were significantly lower in the COVID-19-positive group than the COVID-19-negative group (p<0.05 for all). The severe group had higher median IG, IGLR, neutrophil, NLR, PLR levels than the mild, moderate, and COVID-19-negative groups (p<0.05 for all). Receiver operating characteristic analysis revealed an area under the curve value for IGLR, CAR, CRP, IG, NLR, and ferritin of 0.868, 0.860, 0.834, 0.848, 0.845, 0.841, and 0.827, respectively, which differentiated severe COVID-19 patients from mild and moderate COVID-19 patients. Conclusion:The results suggest that the IGLR may be useful to distinguish severe COVID-19 patients at the time of admission. Further exploration is warranted to fully determine the potential value of the IGLR in disease monitoring.

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Utility of biomarkers in predicting complicated appendicitis: can immature granulocyte percentage and C-reactive protein be used?

Güngör

Göktüğ

Güneylioğlu

et al. 2021

Postgraduate Medicine

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Evaluation of time to positivity for blood culture combined with immature granulocytes, neutrophil‐to‐lymphocyte ratio, and CRP in identifying bloodstream coagulase‐negative Staphylococci infection in pediatric patients

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 8 publications

References 18 publications

Spinal epidural abscess due to coinfection of bacteria and tuberculosis: A case report

Spinal epidural abscess due to coinfection of bacteria and tuberculosis: A case report

Predictive values of immature granulocyte and other inflammatory parameters on disease severity of COVID‐19 patients

Utility of biomarkers in predicting complicated appendicitis: can immature granulocyte percentage and C-reactive protein be used?

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