Evaluation of thyroid hormones and ferritin level in patients with β- thalassemia

Hussein, Sura Zahim

doi:10.15386/mpr-2053

Cited by 7 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies [20][21][22][23] found that severe anemia and serum ferritin levels were signi cantly associated with the incidence of hypertensive disorders, and Wang Yanxia et al [24] also indicated that high iron load causes the body to experience oxidative stress and increased vasoconstriction, leading to the development of hypertensive disorders of pregnancy. If a large amount of iron is deposited in the thyroid gland, chronic brotic changes in its substance can occur, and free iron can catalyze the formation of highly reactive oxygen radicals, leading to cytotoxicity and thyroid functional impairment [25][26].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the pregnancy status and outcomes of pregnant women with α-thalassemia: a retrospective study

Li,

Feng,

Wei

et al. 2024

Preprint

View full text Add to dashboard Cite

Background The prevalence of α-thalassemia co-occurrence with pregnancy may impede maternal system functions, with a consequent adverse effect on pregnancy progression and birth outcomes. The aim of this study was to provide guidance for the prevention and monitoring of perinatal complications of different types of α-thalassemia in pregnancy. Methods The observation group comprised 1371 singleton pregnant women with α-thalassemia. The control group comprised 680 non-thalassemia singleton pregnancies during the same period. The thalassemia genotypes of the observation group were tallied and categorized based on their respective genotypes within the group. Results The hemoglobin in the experimental group was lower than that in the control group, with the lowest hemoglobin in the intermediate group (P < 0.001), and serum ferritin trending in the opposite direction. The most significant decreases in hemoglobin and ferritin during pregnancy were observed in the intermediate group (P<0.001). The incidences of abnormal Electrocardiograph, abnormal liver function, hypertensive disorders, Gestational Diabetes Mellitus and thyroid disorders during pregnancy were higher in the observation group than in the control group (P<0.05). The incidences of preterm labor, caesarean section and postpartum hemorrhage were all higher in the observation group than in the control group (P<0.05). The delivery weight and neonatal hemoglobin in the observation group were lower than those in the control group (P<0.05). Conclusions Pregnant women with α-thalassemia have the more complications of pregnancy and childbirth than non-thalassemic pregnancies. Pregnancy-related indicators should be monitored and corrected in a timely manner.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of the pregnancy status and outcomes of pregnant women with α-thalassemia: a retrospective study

Li,

Feng,

Wei

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Primary hypothyroidism was found in 1.2% of our patients, which is relatively low compared to the literature. However, the onset of this disorder is generally in the second decade of life (33). Most of the patients of hypothyroidism were subclinical (16.6%); their periodic evaluation of the thyroid function was done to detect children of hypothyroidism who need thyroid replacement therapy.…”

Section: Discussionmentioning

confidence: 99%

Pediatrik Beta Talasemi Major Hastalarında Endokrin Komplikasyonlar: Tek Merkez Deneyimi

Yenigürbüz

Akıncı

ÜSTYOL³

et al. 2022

Harran Üniversitesi Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Background: Our aim was to identify risk factors and clinical correlates of endocrine complications in β-thalassemia major (BTM) patients.Materials and methods: This was a retrospective study carried out in the pediatric hematology and pediatric endocrinology departments of a tertiary healthcare institution with the medical data of 249 children with BTM (108 females, 43.4%; 141 males, 56.6%) with a median age of 7.17 (2 -17.8) years. Baseline descriptive, clinical features including endocrine complications and laboratory data were noted. Correlation between the presence of endocrine complications and demographic, clinical, and laboratory variables were sought. The effects of age, gender, race, height, weight, and splenectomy on endocrine complications were evaluated separately in each complication group. Results: Vitamin D deficiency/insufficiency is the most common endocrine complication (41.7%). According to Turkish children, Syrian children had also significantly lower vitamin D concentration (p=0.001). At least one endocrinopathy was reported in the majority of BTM patients (67.9%). Accordingly, pubertal status (p=0.014) and Syrian nationality (p=0.007) had significant impacts on TSH levels. Syrian children and those with delayed puber-ty had greater likelihood for subclinical or evident hypothyroidism. The likelihood of suffering from at least one endocrine complication was higher in older children (p=0.042) and those with Syrian nationality (p=0.025)Conclusion: Disorders of endocrine and metabolic nature are common in children with BTM. Early detection and protocol-based multidisciplinary management of these disorders constitute the most suitable strategies to in-crease patients' quality of life. Surveillance, early detection and treatment, and collaborative follow-up with a multidisciplinary team are the key points in the reduction of the severity and frequency of endocrine complica-tions as well as optimization of therapeutic outcomes.

show abstract

“…Taher et al reported a statistically significant association between thyroid dysfunction with age and a history of splenectomy in patients with thalassemia intermedia [94]. Regular blood transfusions may lead to iron accumulation in the thyroid gland with subsequent glandular parenchyma fibrosis [56,62,95]. However, iron overload, as measured by serum ferritin, is not associated with thyroid dysfunction in several studies, despite claims to the contrary [55,56,[61][62][63]96,97].…”

Section: Hypothyroidismmentioning

confidence: 99%

Endocrinopathies in Hemoglobinopathies: What Is the Role of Iron?

Evangelidis,

Venou,

Fani

et al. 2023

IJMS

View full text Add to dashboard Cite

Hemoglobinopathies, including β-thalassemia and sickle cell disease (SCD), are common genetic blood disorders. Endocrine disorders are frequent manifestations of organ damage observed mainly in patients with β-thalassemia and rarely in SCD. Iron overload, oxidative stress-induced cellular damage, chronic anemia, and HCV infection contribute to the development of endocrinopathies in β-thalassemia. The above factors, combined with vaso-occlusive events and microcirculation defects, are crucial for endocrine dysfunction in SCD patients. These endocrinopathies include diabetes mellitus, hypothyroidism, parathyroid dysfunction, gonadal and growth failure, osteoporosis, and adrenal insufficiency, affecting the quality of life of these patients. Thus, we aim to provide current knowledge and data about the epidemiology, pathogenesis, diagnosis, and management of endocrine disorders in β-thalassemia and SCD. We conducted a comprehensive review of the literature and examined the available data, mostly using the PubMed and Medline search engines for original articles. In the era of precision medicine, more studies investigating the potential role of genetic modifiers in the development of endocrinopathies in hemoglobinopathies are essential.

show abstract

Evaluation of thyroid hormones and ferritin level in patients with β- thalassemia

Cited by 7 publications

References 16 publications

Analysis of the pregnancy status and outcomes of pregnant women with α-thalassemia: a retrospective study

Analysis of the pregnancy status and outcomes of pregnant women with α-thalassemia: a retrospective study

Pediatrik Beta Talasemi Major Hastalarında Endokrin Komplikasyonlar: Tek Merkez Deneyimi

Endocrinopathies in Hemoglobinopathies: What Is the Role of Iron?

Contact Info

Product

Resources

About