Evaluation of three serological tests for diagnosis of Maedi-Visna virus infection using latent class analysis

Toft, Nils; Åkerstedt, Johan; Tharaldsen, Jorun; Hopp, Petter

doi:10.1016/j.vetmic.2006.10.025

Cited by 53 publications

(30 citation statements)

References 10 publications

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“…The model was designed to determine the sensitivity and specificity of three diagnostic tests using data from two populations in the absence of a gold standard using 2 tests that are conditionally dependent (ZME and IFAT) and a third is conditionally independent (PCR). The code for the model was adapted from code provided by Nils Toft, which is published by Toft et al (2007) (See Appendix 1). Data from testing the samples with the ELISA were omitted from the final analysis because the inclusion of these data did not produce repeatable estimates of the parameters of interest regardless of test combination and model used (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…The priors for the conditional covariance for M a n u s c r i p t 11 the ZME and IFAT were modeled using uniform distributions with ranges given by the limits derived in Appendix 1 according to Toft et al (2007).…”

Section: Discussionmentioning

confidence: 99%

“…Appendix 1: WinBUGS code to estimate the prevalence of Giardia infection and the sensitivity and specificity of 2 conditionally dependent tests and one independent test using data from 2 populations (Adapted from (Toft et al, 2007)) …”

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confidence: 99%

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Transmission cycles of Giardia duodenalis in dogs and humans in Temple communities in Bangkok—A critical evaluation of its prevalence using three diagnostic tests in the field in the absence of a gold standard

et al. 2009

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Transmission cycles of Giardia duodenalis in dogs and humans in Temple communities in Bangkok—A critical evaluation of its prevalence using three diagnostic tests in the field in the absence of a gold standard

et al. 2009

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“…A number of approaches have been used to overcome this in the development of welfare indicators, including, the use of a 'Pseudo Gold Standard' Bertrand et al, 2005) and Bayesian methods, such as latent class analysis (LCA; Hui and Walter, 1980). LCA has frequently been applied in the evaluation of veterinary diagnostic tests Toft et al, 2007a;Bonde et al, 2010), and in the evaluation of the diagnostic accuracy of clinical observations of animal-based outcomes of pigs (Baadsgaard and Jørgensen, 2003). Accordingly, this approach was applied in the current study.…”

Section: Introductionmentioning

confidence: 99%

Inter-observer agreement, diagnostic sensitivity and specificity of animal-based indicators of young lamb welfare

Phythian

Toft

Cripps

et al. 2013

Animal

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A scientific literature review and consensus of expert opinion used the welfare definitions provided by the Farm Animal Welfare Council (FAWC) Five Freedoms as the framework for selecting a set of animal-based indicators that were sensitive to the current on-farm welfare issues of young lambs (aged <6 weeks). Ten animal-based indicators assessed by observation -demeanour, response to stimulation, shivering, standing ability, posture, abdominal fill, body condition, lameness, eye condition and salivation were tested as part of the objective of developing valid, reliable and feasible animal-based measures of lamb welfare The indicators were independently tested on 966 young lambs from 17 sheep flocks across Northwest England and Wales during December 2008 to April 2009 by four trained observers. Inter-observer reliability was assessed using Fleiss's kappa (k), and the pair-wise agreement with an experienced, observer designated as the 'test standard observer' (TSO) was examined using Cohen's k. Latent class analysis (LCA) estimated the sensitivity (Se) and specificity (Sp) of each observer without assuming a gold standard and predicted the Se and Sp of randomly selected observers who may apply the indicators in the future. Overall, good levels of inter-observer reliability, and high levels of Sp were identified for demeanour (k 5 0.54, Se > 0.70, Sp > 0. LCA predicted that randomly selected observers had Se . 0.77 (acceptable), and Sp > 0.98 (high) for assessments of demeanour, lameness, abdominal fill posture, body condition and eye condition. The diagnostic performance of some indicators was influenced by the composition of the study population, and it would be useful to test the indicators on lambs with a greater level of outcomes associated with poor welfare. The findings presented in this paper could be applied in the selection of valid, reliable and feasible indicators used for the purposes of on-farm assessments of lamb welfare.

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“…Araştırmacılar farklı doğrulama testleri ile daha çok çalışma yapılması gerektiğini vurgulamışlardır 48 .…”

Section: Gizli Sınıf Analizinin Kullanıldığı Hayvanlarda Yapılan çAlıunclassified

Tanısal Mikrobiyolojide Altın Standart Testin Yokluğunda Gizli Sınıf Analizinin Kullanımı

Abiha¹,

Kanik²

2016

Arşiv Kaynak Tarama Dergisi

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The evaluation of performance of various tests diagnostic tests in the absence of gold standard is an important problem. Latent class analysis (LCA) is a statistical analysis method known for many years, especially in the absence of a gold standard for evaluation of diagnostic tests so that LCA has found its wide application area. During the last decade, LCA method has widely used in for determining sensivity and specifity of different microbiological tests. It has investigated in the diagnosis of mycobacterium tuberculosis, mycobacterium bovis, human papilloma virus, bordetella pertussis, influenza viruses, hepatitis E virus (HEV), hepatitis C virus (HCV) and other various viral infections. Researchers have compared several diagnostic tests for the diagnosis of different pathogens with LCA. We aimed to evaluate performance of latent class analysis method used microbiological diagnosis in various diseases in several researches. When we took into account all of these tests' results, we suppose that LCA is a good statistical analysis method to assess different test performances in the absence of gold standard.

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Evaluation of three serological tests for diagnosis of Maedi-Visna virus infection using latent class analysis

Cited by 53 publications

References 10 publications

Transmission cycles of Giardia duodenalis in dogs and humans in Temple communities in Bangkok—A critical evaluation of its prevalence using three diagnostic tests in the field in the absence of a gold standard

Transmission cycles of Giardia duodenalis in dogs and humans in Temple communities in Bangkok—A critical evaluation of its prevalence using three diagnostic tests in the field in the absence of a gold standard

Inter-observer agreement, diagnostic sensitivity and specificity of animal-based indicators of young lamb welfare

Tanısal Mikrobiyolojide Altın Standart Testin Yokluğunda Gizli Sınıf Analizinin Kullanımı

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