Evaluation of three physiologically based pharmacokinetic (PBPK) modeling tools for emergency risk assessment after acute dichloromethane exposure

Boerleider, R.Z.; Olie, J.D.N.; Eijkeren, J.C.H. van; Bos, Peter; Hof, B.G.H.; Vries, Irma de; Bessems, Jos; Meulenbelt, Jan; Hunault, Claudine C.

doi:10.1016/j.toxlet.2014.10.010

Cited by 3 publications

(2 citation statements)

References 27 publications

(40 reference statements)

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“…Chelation produces sulfonium ion which, due to its electrophilic characteristics, may attack nucleophilic centres in DNA (Figure 13). One of examples for chemicals that form sulfonium ion is dichloromethane [10]. The substance is used as the leaching agent not only in the industry but also in production of decaffeinated coffee and tea.…”

Section: Genotoxicity -A Predictable Risk To Our Actual Worldmentioning

confidence: 99%

Assessment of Potential Carcinogenicity by Quantitative Structure-Activity Relationship (QSAR)

Želježić¹

2018

Genotoxicity - A Predictable Risk to Our Actual World

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Already in 1978, Elisabeth C. Miller and James A. Miller came with a presumption that electrophilic molecules are predicted to be carcinogens. It is because DNA molecule is reached in nucleophilic centres that may covalently bind to such substances. Rules deduced by Millers are even nowadays irrefutable, and they are used as the basis of testing of the substance for its carcinogenicity potential. Toxicological discipline that emerged from Millers' research is based on dependence of chemical structure of the substance and their biological activity. Even further, there are strict regularities between molecular structures and activities. The tool used in assessment of biological activity of a substance is known as SAR, an abbreviation from structure-activity relationship. Besides electrophilic centres, in assessment of carcinogenic potential of a substance, the SAR also encounters chemical surrounding (neighbouring functional groups), size of the substance, its lipophilicity, number and position of aryl rings, substitutions of hydrogens, epoxides in aliphatic moieties or rings, resonance stabilisation, etc. To these days, SAR has been upgraded to quantitative SAR (QSAR) which applies multivariate statistical methods quantitatively comparing detected characteristics of "alerts" with biological activity of known carcinogens. Nowadays, chemical industry developing novel active substances is unthinkable without application of QSAR.

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Section: Genotoxicity -A Predictable Risk To Our Actual Worldmentioning

confidence: 99%

Assessment of Potential Carcinogenicity by Quantitative Structure-Activity Relationship (QSAR)

Želježić¹

2018

Genotoxicity - A Predictable Risk to Our Actual World

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“…6,7 Occupational exposure to DCM is frequent and reportedly causes both acute and chronic toxicity. 6,8,9 Previous studies have classified DCM as carcinogenic in humans due to carcinogenicity observed in liver and lung of B6C3F1 mice. [10][11][12] Also, epidemiologic studies on DCM provided additional data, which have raised concerns due to its associations with non-Hodgkin lymphoma and multiple myeloma.…”

Section: Introductionmentioning

confidence: 99%

Dichloromethane and ethanol co-exposure aggravates oxidative stress indices causing hepatic and renal dysfunction in pubertal rats.

Owumi

Najophe

2019

Toxicology Research and Application

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Toxicological effects from chemical interaction may result in weaker or stronger effects. The present study investigated the influence of acute oral co-exposure to dichloromethane (DCM) and ethanol (EtOH) in rats. Four groups of rats were treated for seven consecutive days with corn oil, DCM at 150 mg/kg alone, EtOH at 5 g/kg alone, and both DCM and EtOH, respectively. Subsequently, biomarkers of hepatic and renal functions, cellular antioxidant defense systems, and oxidative stress indices were analyzed in the liver and kidney samples. Results indicated that the significant (p < 0.05) elevations in the biomarkers of hepatic and renal toxicity following exposure of rats to DCM alone and EtOH alone were aggravated in the co-exposure group. Further, the significant reductions in the antioxidant status and the increase in lipid peroxidation in the liver and kidney of rats following exposure to DCM alone and EtOH alone were aggravated in the coexposure group. Histological alterations of rats treated with DCM alone and EtOH alone were worsened in the coexposure group. In summary, co-exposure to DCM and EtOH elicited more harmful effects on the liver and kidney than the individual chemical exposure, which is attributable to the intensified oxidative stress in the treated rats.

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New double layered Co(II)–organic framework for sensing of dichloromethane and Fe3+ ions

Zeng

Han

Cui

2021

Inorganic Chemistry Communications

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Evaluation of three physiologically based pharmacokinetic (PBPK) modeling tools for emergency risk assessment after acute dichloromethane exposure

Cited by 3 publications

References 27 publications

Assessment of Potential Carcinogenicity by Quantitative Structure-Activity Relationship (QSAR)

Assessment of Potential Carcinogenicity by Quantitative Structure-Activity Relationship (QSAR)

Dichloromethane and ethanol co-exposure aggravates oxidative stress indices causing hepatic and renal dysfunction in pubertal rats.

New double layered Co(II)–organic framework for sensing of dichloromethane and Fe3+ ions

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