Evaluation of thermal stability of enalapril maleate tablets using thermogravimetry and differential scanning calorimetry

Souza, Steffany Manzan Marques de; Franco, Pedro Ivo Brandão e Melo; Leles, Maria Inês Gonçalves; Conceição, Edemilson Cardoso da

doi:10.1007/s10973-015-4648-3

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…Thermogravimetry and DSC are effective ways to illustrate the stabilities and formation of microcapsules ( 47 – 49 ) by probing the relationship between temperature and mass variation ( 50 ). Results are shown in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

Temperature controlled microcapsule loaded with Perilla essential oil and its application in preservation of peaches

Tai

Zheng²,

Yang³

et al. 2023

Front. Nutr.

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In this study, Perilla frutescens essential oil (PEO) loaded microcapsules (PEOM) were successfully prepared and their thermal stability, temperature-responsive releasing effect, antioxidant activity, antibacterial activity, and preservation of peach were systematically investigated. PEOM showed excellent encapsulation efficiency (91.5%) with a core-shell ratio of 1.4:1 and exhibited high thermal stability, indicating that PEOM could effectively maintain PEO release rate. In vitro assays indicated that the optimal kinetic model for PEO release fitted well with first order with a diffusion mechanism. A high level of antioxidant and antibacterial activity of PEOM was maintained. In addition, owing to its sustained release, PEOM could prolong the shelf life of peaches significantly. Therefore, PEOM has potential application and development prospects in the field of food preservation.

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Section: Resultsmentioning

confidence: 99%

Temperature controlled microcapsule loaded with Perilla essential oil and its application in preservation of peaches

Tai

Zheng²,

Yang³

et al. 2023

Front. Nutr.

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“…Thermogravimetric analysis (TGA) confirmed the decomposition of enalapril maleate as observed in the DSC data. TGA showed an onset at a temperature of approximately 154 °C and a mass loss of approximately 27% up to a temperature of 220 °C ( Figure 6 a) [ 27 , 28 ]. The derivative thermogravimetric curve showed the maximum of the initial decomposition at a temperature of approximately 168 °C ( Figure 6 b).…”

Section: Resultsmentioning

confidence: 99%

Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate

2022

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The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME). A fast HPLC method was developed to quantify enalapril maleate and possible degradation products. Screening experiments revealed that the diketopiperazine derivative (Impurity D) was the main degradation product. Hot-melt extrusion of enalapril maleate with the polymer Soluplus® enabled extrusion at 100 °C, whereas a formulation with the polymer Eudragit® E PO could be extruded at only 70 °C. Extrusion at 70 °C prevented thermal degradation. A stabilizing molecular interaction between enalapril maleate and Eudragit® E PO was identified via FT-IR spectroscopy. Dissolution studies were carried out to study the influence of the formulation on the dissolution behavior of enalapril maleate. These promising results can be transferred to other thermo-sensitive and peptidomimetic drugs to produce extrudates which can be used, for instance, as feedstock material for the production of patient-specific dosage forms via Fused Deposition Modeling (FDM) 3D printing.

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Studies on charge transfer of enalapril maleate: from solid-state to molecular dynamics

Lourenço

Santin²,

Fajemiroye

et al. 2023

J Mol Model

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Evaluation of thermal stability of enalapril maleate tablets using thermogravimetry and differential scanning calorimetry

Cited by 7 publications

References 19 publications

Temperature controlled microcapsule loaded with Perilla essential oil and its application in preservation of peaches

Temperature controlled microcapsule loaded with Perilla essential oil and its application in preservation of peaches

Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate

Studies on charge transfer of enalapril maleate: from solid-state to molecular dynamics

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