Evaluation of Therapeutic Efficacy of Ascorbic Acid in Patients with Bronchial Asthma

Akhtar, Razi; Jain, Siddharth; Kumar, Abhishek; Bhatia, Subhash C.; Joshi, Jagdish C.; Singh, Dhirendra Kumar; Shamsuzzaman, _; Sharma, Meenakshi; Pal, Giridhari; Vijayan, V K; Gaur, S N; Gulati, Kavita; Ray, Arunabha

doi:10.5530/jyp.2016.3.8

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…It is an effective antioxidant and a potential scavenger of free radicals, due mainly to the ascorbate ion [14]. The protective role of vitamin C in this study is due to its antioxidant property which has been reported in previous studies [6,15,16].…”

Section: Discussionsupporting

confidence: 66%

“…Ascorbic acid (vitamin C) is an effective antioxidant which has the prospective to scavenge free radicals such as aqueous peroxyl radicals, superoxide anions and hydroxyl radicals [6]. Eizadi-Mood et al analysed 29 medical records of patients who received renowned antioxidants such as vitamin C and E together with regular treatment for paraquat poisoning and concluded that although adding antioxidant to normal treatment could not diminish the death rate, and suggested future investigations with higher amount of antioxidants [7].…”

Section: Introductionmentioning

confidence: 99%

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Effect of vitamin C on N,N′-dimethyl-4,4′-bipyridinium dichloride-induced hepatic and renal toxicity in Swiss albino mice

Chohan¹,

Mohafez²,

Rasool³

et al. 2018

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Effect of vitamin C on N,N′-dimethyl-4,4′-bipyridinium dichloride-induced hepatic and renal toxicity in Swiss albino mice

Chohan¹,

Mohafez²,

Rasool³

et al. 2018

Trop. J. Pharm Res

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“…One previous study stated that ascorbic acid has no established bronchodilatory or anti-inflammatory effect. [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

A prospective randomized controlled study: Theophylline on oxidative stress and steroid sensitivity in chronic obstructive pulmonary disease patients

R¹,

Vinotha

2017

Int J Pharma Investig

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Objective:Oxidative stress is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Corticosteroid fails to suppress inflammation and oxidative stress due to steroid resistance. Theophylline has an effect on histone deacetylase (HDAC) activity and improves steroid sensitivity in COPD. Given changes in oxidative stress associated with diminished corticosteroid effects, a clinical study in which antioxidants and free radicals are estimated can suggest a correlation between antioxidants, theophylline, and corticosteroid sensitivity.Materials and Methods:A randomized controlled study was conducted in 60 participants divided into 4 groups: Group I (controls) - 15 normal healthy volunteers, Group II - COPD patients who received theophylline 300 mg + salbutamol 8 mg, Group III - patients who inhaled budesonide 400 μg + salbutamol 8 mg, and Group IV – theophylline 300 mg + inhaled budesonide 400 μg + salbutamol 8 mg 12 weeks. Blood samples were collected at the time of diagnosis and at 4-week interval for 3 months from all the groups and antioxidant parameters, spirometric % forced expiratory volume in 1 s (FEV1) were measured.Results:The mean difference between groups was analyzed using one-way ANOVA. There was a significant increase in antioxidant enzymes such as catalase, glutathione (GSH) serum transferase, (P < 0.05), reduced GSH, and superoxide dismutase (P < 0.01) and a significant decrease in lipid peroxidation (P < 0.01) at 12 weeks of the study period. Postbronchodilator FEV1 values have also shown a significant increase at 12 weeks (P < 0.01).Conclusion:Theophylline increases the expression and activity of HDAC and improves steroid sensitivity thereby decreases oxidative stress. Hence, novel therapeutic strategy is therefore the reversal of this corticosteroid resistance by increasing the expression and activity of HDAC achieved using corticosteroids along with theophylline.

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“…In another study, Akhtar et al (2016) evaluated the therapeutic efficacy of ascorbic acid, an anti-oxidant drug in bronchial asthma patients. A total of 86 patients of bronchial asthma were enrolled for the study and finally 50 patients were used for primary analysis.…”

Section: Obstructive Airway Diseasesmentioning

confidence: 99%

Status of Research in Respiratory Pharmacology in India during the last Five Years (2012-2017)

Gulati¹,

Rai²,

Ray³

2018

Proceedings of the Indian National Science Academy

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Research in the area of respiratory pharmacology and toxicologyis very exciting and vital for the development of new drugs with more efficacy and safety. Several medicinal plants from the Ayurveda and Unani systems of medicine are being evaluated for their efficacy and safety by using modern medical techniques;with an aim to bring them to the mainstream of the health care system. Effects of yogic intervention on pulmonary functions, cellular and molecular markers and quality of life in patients of bronchial asthma are also being assessed. Further, a lot of work is also going on novel aspects of immunotherapy and nanomedicine in the management of respiratory disorders. This review also highlights the relevance and pharmacoeconomic impact of nutraceuticals in prevention and treatment of respiratory diseases. Many clinical trials are being conducted to compare the efficacy and safety of already marketed individual drugs and combination therapy. Pharmacovigilance studies are being conducted to monitor the ADRs during pharmacotherapy of respiratory diseases, assess the causal relationship and find ways to prevent the ADRs to rationalize the therapy. However, more translational research is needed to bring scientific advances and knowledge into clinical practice; and there is a great need to find effective ways for collaboration between various research disciplines. There should be a focus on earlier and more specific diagnosis of respiratory diseases as well as better targeted and personalized treatments which may save cost, reduce adverse effects and improve disease outcomes and quality of life.

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Evaluation of Therapeutic Efficacy of Ascorbic Acid in Patients with Bronchial Asthma

Cited by 4 publications

References 6 publications

Effect of vitamin C on N,N′-dimethyl-4,4′-bipyridinium dichloride-induced hepatic and renal toxicity in Swiss albino mice

Effect of vitamin C on N,N′-dimethyl-4,4′-bipyridinium dichloride-induced hepatic and renal toxicity in Swiss albino mice

A prospective randomized controlled study: Theophylline on oxidative stress and steroid sensitivity in chronic obstructive pulmonary disease patients

Status of Research in Respiratory Pharmacology in India during the last Five Years (2012-2017)

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