Abstract:Background:A positron emission tomography (PET) radiotracer to neuroimage α-synuclein aggregates would be a crucial addition for early diagnosis and treatment development in disorders such as Parkinson's disease, where elevated aggregate levels is a histopathological hallmark. The radiotracer (d3)-[11C]MODAG-001 has recently shown promise for visualization of α-synuclein pre-formed fibrils (α-PFF) in rodents. We here test the radiotracer in a pig model where proteins are intracerebrally injected immediately be… Show more
“…MODAG-001 in αSyn-inoculated pigs and demonstrated sufficient brain uptake of the tracer [35]. Ono et al reported that [ 18 F]C-05-05, a compound developed based on the tau imaging tracer PBB3 structure, showed specific detection of pS129 antibody-positive phosphorylated αSyn in an αSyn-inoculated mouse model as well as in an αSyn-inoculated nonhuman primate model [34].…”
Section: Raval Et Al Recently Reported a Further Evaluation Of (D3)-[...mentioning
“…MODAG-001 in αSyn-inoculated pigs and demonstrated sufficient brain uptake of the tracer [35]. Ono et al reported that [ 18 F]C-05-05, a compound developed based on the tau imaging tracer PBB3 structure, showed specific detection of pS129 antibody-positive phosphorylated αSyn in an αSyn-inoculated mouse model as well as in an αSyn-inoculated nonhuman primate model [34].…”
Section: Raval Et Al Recently Reported a Further Evaluation Of (D3)-[...mentioning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.