Evaluation of the volatiles’ chemical profile and antibacterial activity of Lavandula stoechas L. extracts obtained by supercritical carbon dioxide

Vladić, Jelena; Jerković, Igor; Svilović, Sandra; Pavić, Valentina; Pastor, Kristian; Paiva, Alexandre; Jokić, Stela; Rebocho, Sílvia; Duarte, Ana Rita C.

doi:10.1016/j.scp.2023.101126

Cited by 2 publications

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“…In our previous study based on which the conditions for the supercritical extraction were selected, the obtained extracts were analyzed by the GC-MS method. Therefore, to confirm the chemical composition of the extract obtained in this study (conditions 200 bar, 40 °C, and 3 h), GC-MS was also applied, and the results were similar to the ones reported (Figure 2), where the total extraction yield was 1.99% (w/w) [21] In the GC-MS profile of the extract, oxygenated terpenes were the most abundant with 72.21%. Within oxygenated terpenes, monoterpenes were more dominant (55.41%) with major components fenchone (12.93 ± 2.94%) and verbenone (12.08 ± 1.27), followed by camphor (7.80 ± 2.46) and 1,8cineole (7.51 ± 2.02%).…”

Section: Chemical Profile Of L Stoechas Extract Obtained By Supercrit...supporting

confidence: 86%

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Towards a Greener Approach for Biomass Valorization: Integration of Supercritical Fluid and Deep Eutectic Solvents

et al. 2023

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A green and sustainable procedure for obtaining Lavandula stoechas extracts with antioxidant and antimicrobial properties was investigated. Green solvents, supercritical CO2, and natural deep eutectic solvents (NADES) together with ultrasound-assisted extraction were used for the sequential extraction of terpene and polyphenols fractions. After the CO2 extraction of the terpene fraction, the residue material was used in an extraction with different NADES (betaine-ethylene glycol (Bet:EG), betaine-glycerol (Bet:Gly), and glycerol-glucose (Gly:Glu)), intensified with an ultrasound-assisted method (at 30 and 60 °C). In the CO2 extract, the major group of components belonged to oxygenated monoterpenes, while the highest polyphenol content with the dominant rutin (438.93 ± 4.60 µg/mL) was determined in Bet:EG extracts (60 °C). Bet:EG extracts also exhibited the most potent antioxidant activity according to DPPH, ABTS, and FRAP assays. Moreover, Bet:EG extracts showed significant inhibitory activity against Gram-positive and Gram-negative bacteria, with minimum inhibitory activity of 0.781–3.125 and 1.563–6.250 mg·mL−1, respectively. By comparing the polyphenolic content and antioxidant and antimicrobial activities of Bet:EG extracts with extracts obtained with conventional solvents (water and ethanol), the superiority of NADES was determined. The established environmentally friendly procedure unifies the requirements of green and sustainable development and modern pharmacognosy because it combines the use of safe alternative solvents, the absence of solvent waste generation, more rational use of resources, and the attainment of safe and quality extracts.

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Section: Chemical Profile Of L Stoechas Extract Obtained By Supercrit...supporting

confidence: 86%

“…All experiments were performed in triplicates. The parameters of extraction were selected based on the previously conducted experimental work [ 21 ]. The obtained extracts were stored at 4 °C until further analysis.…”

Section: Methodsmentioning

confidence: 99%