Evaluation of the Validity of SAMe-TT₂R₂ Score in a Cohort of Venous Thromboembolism Patients Treated With Warfarin

Abstract

Low SAMe-TT2R2 score of <2 was validated as a predictor of optimum anticoagulation control, reflected by mean time in therapeutic range (TTR) above 65% to 70%, among warfarin-treated atrial fibrillation patients. This study aimed to validate the ability of SAMe-TT2R2 score and its individual components in predicting anticoagulation control (mean TTR and clinical events) among a cohort of venous thromboembolism (VTE) patients in Qatar. A total of 295 patients were retrospectively evaluated. There was a trend toward statistical significance in mean TTR between low (<2) and high (≥ 2) SAMe-TT2R2 score groups ( P = .05), a difference that was not sustained when a cutoff of 3 was used (ie, a score of 3 or more). Patients with poor INR control (TTR <70%) were numerically less likely to have SAMe-TT2R2 score of <2 compared with those with good INR control, though the difference was not statistically significant (16.7% vs 83.3%, respectively, P = .4). No thromboembolic events were reported, and no association was found between the score and risk of bleeding. Non-Caucasian origin was the only significant predictor of good anticoagulation in the studied cohort. In conclusion, SAMe-TT2R2 score could not predict quality of anticoagulation control in a cohort of VTE patients treated with warfarin in Qatar. Contribution of other clinical factors and whether a different scoring may yield better prediction of anticoagulation control remains to be tested.

Drive‐up INR testing and phone‐based consultations service during COVID‐19 pandemic in a pharmacist‐lead anticoagulation clinic in Qatar: Monitoring, clinical, resource utilization, and patient‐ oriented outcomes

“…This could be attributed to the small sample size and relatively short follow‐up period. Furthermore, these findings are parallel to results of previous studies indicating low warfarin related complications in Qatar's population 28,29 . With regard to resource utilization after service transition, the current study revealed a significant decline in the frequency of INR testing and patients' compliance to attending scheduled clinic visits (a mean difference of 22.4).…”

“…Furthermore, these findings are parallel to results of previous studies indicating low warfarin related complications in Qatar's population. 28,29 30,31 Another aspect evaluated by this study was patients' satisfaction with drive-up testing and telehealth anticoagulation management. The provision of telehealth is generally limited by patients' access to hitech devices required to conduct a visit; internet access; level of comfort with technology and cultural acceptance of replacing in-person visits by virtual ones.…”