Evaluation of the Validity of High Serum Antistreptolysin O Titre Only, as an Indication for Tonsillectomy

Hembrom, Rabi; Roychaudhuri, B. K.; Saha, Arin; Roychowdhury, Amitabha; Ghosh, Soumitra; Gon, Sabyasachi; Mandal, Kousik

doi:10.1007/s12070-012-0579-5

Cited by 12 publications

(10 citation statements)

References 7 publications

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“…In comparison between the first group with high ASO titr and negative throat swab (104) and the second group with high ASO titre and positive swab (52), the improved rate was 27.4% in the first group and 84.4% in the second group with a p value of 0.001 which is statistically significant. Our results are in line with Hombrom et al 2012 [1] who concluded that one should perform throat swab culture along with ASO titre before doing tonsillectomy in absence of any other indications. Viswanathan et al 2000 [2], reported that there were significant reduction of sore throat attacks after tonsillectomy within one year after operation.…”

Section: Discussionsupporting

confidence: 92%

“…A single titre of more than 200 iu/ml is considered as a raised value. Serum ASO titre is raised when there is an infection of any organ of the body by GABHS, so the increased serum ASO titre should not be the only deciding criterion for tonsillectomy if GABHS is not present in the palatine tonsils [1]. GABHS is the most common bacteria that cause acute tonsillitis.…”

Section: Introductionmentioning

confidence: 99%

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The Value of High Antistreptolysin O Titre as an Indicator of Tonsillectomy in Upper Egypt

Elmagd¹,

Meguid²,

Tahan³

2016

IJOHNS

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Background: In this study, we aimed to evaluate the benefit of performing of tonsillectomy in patients with raised serum ASO titre only in absence or presence of group A beta heamolytic streptococci (GABHS) in throat swab. Materials and methods: In this prospective cohort study, 196 patients below the age of 14 were suffering from non-specific streptococcal infections, without fulfilling the clinical parameters used for the diagnosis of chronic tonsillitis 156 patients had a raised ASO titre above 200 iu/ml. Throat swab culture was performed in all patients. Results: The results showed that out of the 156 patients, 52 had positive throat swab for GABHS. All of the patients underwent tonsillectomy. Follow-up of the patients for one year after the operation, 88% of the first group with high ASO titre and positive throat swab showed improvement of symptoms; 25% of the second group with high ASO titre and negative throat swab showed improvement of symptoms. Conclusion: Our study shows that isolation of GABHS from the patients tonsils by throat swab along with high ASO titre may be an indication of tonsillectomy in absence of any other indications.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Value of High Antistreptolysin O Titre as an Indicator of Tonsillectomy in Upper Egypt

Elmagd¹,

Meguid²,

Tahan³

2016

IJOHNS

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“…23 ASO titre remains the most sensitive serological indices of antecedent Group A beta-haemolytic streptococcal infection. 24 In present study it was observed that there was a reduction in ASO titres to levels <200 IU/ml post tonsillectomy. At the end of first follow up (1 month after surgery) 12 (48%) out of 25 patients showed ASO titre < 200 IU/ml; two tailed p-value = 0.0001, which was statistically significant.…”

Section: Discussionsupporting

confidence: 50%

Tonsillectomy and its effect on ASO titre

Bharti¹,

Mohindroo²,

Mohindroo³

et al. 2017

Int J Res Med Sci

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Background: Acute tonsillitis is one of the most common manifestations of the upper respiratory tract infections. It is common in children and accounts for an incidence of about 32 per 1000 patients per year. The objective of this study was to determine the effect of tonsillectomy on ASO titre and to evaluate the sensitivity and specificity of throat swab culture.Methods: Present study performed a prospective study, a total number of 50 children were screened, out which 25 patients under the age of 15 years (16 male and 9 female), were included in the study, who were having chronic tonsillitis with raised anti-streptolysin O titre (>200IU/ml). All the patient underwent tonsillectomy and serological estimation of ASO titre was done at the end of first, second and third month post-surgery. Throat swab culture was performed prior to tonsillectomy and at the third month of follow up.Results: Twelve children (48%), twenty children (80%) and twenty-two children (88%) became serologically negative for ASO antibody at the end of first, second and third month respectively, with a statistically significant p value of 0.0001. The sensitivity and specificity of throat swab culture was 16% and 100% respectively.Conclusions: Tonsillectomy has a significant role in reducing the serological levels of anti-streptolysin O antibody and its reactivation, thereby decreasing the rate of complications associated with Group A-beta haemolytic streptococci.

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“…в 13% случаев, что совпадает с данными других исследований [12]. Многие авторы отмечают низкую выявляемость Streptococcus pyogenes в мазках из глотки [6,12] и отдают предпочтение бактериологическому исследованию материала, полученного посредством тонкоигольной биопсии небных миндалин [13]. Повышение титра АСЛО зарегистрировано нами гораздо чаще, чем выявление БГСА, -у 42 (77,7%) из 54 больных.…”

Section: результаты и обсуждениеunclassified

“…[13] провели проспективное когортное исследование 50 больных с хроническим тонзиллитом, подвергнутых двусторонней тонзиллэктомии. Всем больным перед операцией проведено определение титра АСЛО и бактериологическое исследование материала, полученного с поверхности небных миндалин и при их тонкоигольной биопсии, которую многиe авторы считают «золотым стандартом» выявления БГСА [6,13]. При сравнении результатов трех исследований авторы пришли к заключению, что специфичность теста АСЛО при хроническом тонзиллите не превышает 12%.…”

Section: результаты и обсуждениеunclassified

The significance of antistreptolysin O characteristics for the determination of indications for tonsillectomy in the children

Бойко

Kim

Stagnieva

et al. 2018

Vestn. otorinolaringol.

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The objective of the present work was to evaluate the diagnostic significance of the measurement of the antistreptolysin O (ASLO) titers in the children presenting with chronic tonsillitis for determining the indications for tonsillectomy. The study included 54 patients at the age varying from 4 to 17 years who had undergone bilateral tonsillectomy for the treatment of chronic tonsillitis. The diagnosis was confirmed by the results of the histological study of the removed amygdalae. Prior to surgery, all the patients had been subjected to the bacteriological investigation of the smears taken from the surface of the palatal tonsils. The titers of antistreptolysin O in the serum were determined with the use of the kinetic nephelometric technique before, 6 and 12 months after the surgical intervention. The results of the measurements were treated using the Statzilla software package (version 3.2, R Foundation for Statistical Computing, Vienna, Austria). Streptococcus pyogenes (group A) was identified only in 7 (13%) patients. The initially enhanced content of ASLO ranging from 273 to 1880 IU/ml was documented in 42 (77.7%) of the 54 patients. Twelve patients had the ASLO titers within the normal limits (from 13 to 124 IU/ml). The removal of palatal tonsils resulted in a significant decrease of the ASLO titers in the patients who had presented with the initially enhanced content of antistreptolysin O (p < 0.05); nevertheless, their ASLO titers remained higher than the normal values in 69% and 82% of the patients examined within 6 and 12 months after the surgical intervention, respectively. The patients who had exhibited the high levels of antistreptolysin O during the preoperative period did not experience normalization of this parameter after surgery. It is concluded, taking into account the absence of correlation between the enhancement of serum antistreptolysin O titers and the presence of group A beta-chemolytic Streptococci (BCSA), that the result of the measurement of ASLO titers can not be considered as a valid indication for tonsillectomy in the children.

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Evaluation of the Validity of High Serum Antistreptolysin O Titre Only, as an Indication for Tonsillectomy

Cited by 12 publications

References 7 publications

The Value of High Antistreptolysin O Titre as an Indicator of Tonsillectomy in Upper Egypt

The Value of High Antistreptolysin O Titre as an Indicator of Tonsillectomy in Upper Egypt

Tonsillectomy and its effect on ASO titre

The significance of antistreptolysin O characteristics for the determination of indications for tonsillectomy in the children

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