Evaluation of the utility of <sup>99m</sup>Tc‐MDP bone scintigraphy versus MIBG scintigraphy and cross‐sectional imaging for staging patients with neuroblastoma

Gauguet, Jean-Marc; Pace-Emerson, Tamara; Grant, Frederick D.; Shusterman, Suzanne; DuBois, Steven G.; Frazier, Lindsay; Voss, Stephan D.

doi:10.1002/pbc.26601

Cited by 11 publications

(3 citation statements)

References 21 publications

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“…MIBG is a radiolabeled molecule similar in structure to norepinephrine, that is taken up by the norepinephrine transporter in 90% of neuroblastomas (Dubois, et al, 2012). Thus, an MIBG scan provides an extremely specific method of discovering and following sites of metastases, which is more specific and sensitive than technetium bone scan (Gauguet, et al, 2017). MIBG can be combined with other imaging modalities such as is done in a single-photon emission computed tomography (SPECT) to provide more exact anatomical localization of the MIBG uptake (Figure 2C) (Biermann, et al, 2013).…”

Section: Evaluation Staging and Screeningmentioning

confidence: 99%

Neuroblastoma: clinical and biological approach to risk stratification and treatment

2018

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Neuroblastoma is the most common extra-cranial solid tumor of childhood and the most common in the first year of life. It is a unique malignancy in that infants often present with either localized or metastatic disease that can spontaneously regress without intervention while older children can succumb to the disease after months to years of arduous therapy. Given this wide range of outcomes, the International Neuroblastoma Risk Group was created to stratify patients based on presenting characteristics and tumor biology in order to guide intensity of treatment strategies. The goal has been to decrease therapy for low-risk patients to avoid long-term complications while augmenting and targeting therapies for high-risk patients to improve overall survival. The international risk stratification depends on age, stage, histology, MYCN gene amplification status, tumor cell ploidy and segmental chromosomal abnormalities. Treatment for asymptomatic low-risk patients with an estimated survival of > 98% is often observation or surgical resection alone, whereas intermediate-risk patients with an estimated survival of > 90% require moderate doses of response-adjusted chemotherapy along with resection. High-risk patients undergo multiple cycles of combination chemotherapy before surgery, followed by consolidation with myeloablative autologous hematopoietic stem cell transplantation and local radiation and finally immunotherapy with differentiation therapy as maintenance phase. With this approach, outcome for patients with neuroblastoma has improved, as the field continues to expand efforts in more targeted therapies for high-risk patients.

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Section: Evaluation Staging and Screeningmentioning

confidence: 99%

Neuroblastoma: clinical and biological approach to risk stratification and treatment

2018

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“…Gauguet и соавт. (2017) [22] и подтверждено результатами нашей работы. Безусловно, ключевым фактором в снижении количества исследований сцинтиграфии костей скелета, как, возможно, и других дополнительных методов исследования, станет доступность/возможность выполнения сцинтиграфии с 123 I-МЙБГ у пациента с НБ в максимально короткие сроки на этапе инициальной диагностики (до проведения хирургического лечения).…”

Section: рисунокunclassified

Indication of 99mTc-MDP bone scan after 123I-MIBG scintigraphy in patients with neuroblastoma

Kailash

Киреева

Вдовина

et al. 2019

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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123I-MIBG (metaiodobenzylguanidine) scintigraphy and 99mTc-MDP bone scintigraphy (bone scan) are widely used in diagnosis and staging of NB. Consecutively using both methods lead to overall radiation exposure. As most of the patients need additional anesthesia to perform these diagnostic procedures, which accordingly increase the side effect, workload and expenditure. To minimize the exposure, side effect, workload and expenditure, we set the tasks to optimize the diagnostic algorithm. Determine the indications of bone scan after 123I-MIBG scintigraphy. Materials and Methods: 129 patients with NB were included in retrospective study who underwent both diagnostic procedures at interval of less than 30 days at the stage of initial diagnostic procedure using standard protocols. Out of 83 MIBG positive patients bone scan was able to detect metastatic lesions only in 48 patients. However, bone scan had revealed metastatic lesions in 3 out of 14 MIBG-negative patients. Bone scan is indicated only in MIBG-negative neuroblastoma patients; and in cases where the MIBG uptake cannot be determined for example after operative treatment or after starting of chemotherapy.

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“…Nuclear medicine imaging methods are considered an essential diagnostic tool for JIA disease [7,8]. Two-phase bone scintigraphy with [ 99m Tc] Tc-MDP is an easy whole-body evaluation with low cost and radiation burden applied and proved promising in adult RA staging and follow up [9,10]. The blood pool phase is approved to detect disease activity and diagnose early arthritic changes [11].…”

Section: Introductionmentioning

confidence: 99%

Machine learning diagnosis of active Juvenile Idiopathic Arthritis on blood pool [99MTc] Tc-MDP scintigraphy images

Kian ara,

Alemohammad,

Paymani

et al. 2024

Nuclear Medicine Communications

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Purpose Neural network has widely been applied for medical classifications and disease diagnosis. This study employs deep learning to best discriminate Juvenile Idiopathic Arthritis (JIA), a pediatric chronic joint inflammatory disease, from healthy joints by exploring blood pool images of 2phase [99mTc] Tc-MDP bone scintigraphy. Methods Self-deigned multi-input Convolutional Neural Network (CNN) in addition to three available pre-trained models including VGG16, ResNet50 and Xception are applied on 1304 blood pool images of 326 healthy and known JIA children and adolescents (aged 1–16). Results The self-designed model ROC analysis shows diagnostic efficiency with Area Under the Curve (AUC) 0.82 and 0.86 for knee and ankle joints, respectively. Among the three pertained models, VGG16 ROC analysis reveals AUC 0.76 and 0.81 for knee and ankle images, respectively. Conclusion The self-designed model shows best performance on blood pool scintigraph diagnosis of patients with JIA. VGG16 was the most efficient model rather to other pre-trained networks. This study can pave the way of artificial intelligence (AI) application in nuclear medicine for the diagnosis of pediatric inflammatory disease.

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Evaluation of the utility of ^99mTc‐MDP bone scintigraphy versus MIBG scintigraphy and cross‐sectional imaging for staging patients with neuroblastoma

Abstract: In the staging of neuroblastoma, Tc-MDP bone scintigraphy does not identify unique sites of disease that affect disease stage or clinical management, and in the majority of cases bone scans can be omitted from the routine neuroblastoma staging algorithm.

Cited by 11 publications

References 21 publications

Neuroblastoma: clinical and biological approach to risk stratification and treatment

Neuroblastoma: clinical and biological approach to risk stratification and treatment

Indication of 99mTc-MDP bone scan after 123I-MIBG scintigraphy in patients with neuroblastoma

Machine learning diagnosis of active Juvenile Idiopathic Arthritis on blood pool [99MTc] Tc-MDP scintigraphy images

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Evaluation of the utility of 99mTc‐MDP bone scintigraphy versus MIBG scintigraphy and cross‐sectional imaging for staging patients with neuroblastoma

Abstract: In the staging of neuroblastoma, Tc-MDP bone scintigraphy does not identify unique sites of disease that affect disease stage or clinical management, and in the majority of cases bone scans can be omitted from the routine neuroblastoma staging algorithm.

Cited by 11 publications

References 21 publications

Neuroblastoma: clinical and biological approach to risk stratification and treatment

Neuroblastoma: clinical and biological approach to risk stratification and treatment

Indication of 99mTc-MDP bone scan after 123I-MIBG scintigraphy in patients with neuroblastoma

Machine learning diagnosis of active Juvenile Idiopathic Arthritis on blood pool [99MTc] Tc-MDP scintigraphy images

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Evaluation of the utility of ^99mTc‐MDP bone scintigraphy versus MIBG scintigraphy and cross‐sectional imaging for staging patients with neuroblastoma