Evaluation of the utility of the HemoCue 301 haemoglobinometer for blood donor screening

Morris, L.D.; Osei-Bimpong, Andrew; D, McKeown; Roper, David; Lewis, S. M.

doi:10.1111/j.1423-0410.2007.00919.x

Cited by 41 publications

(39 citation statements)

References 7 publications

(10 reference statements)

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“…Another advantage of measuring only WBC and haemoglobin is the speed, with a WBC achieved in minutes using the Hemocue WBC® (Osei-Bimpong et al , 2009) and the haemoglobin obtainable within a minute using the Hemocue Hb 301® (HemoCue AB, Angelholm, Sweden); the key advantage of such point-of-care testing is the rapid time from sampling to the result being involved in a clinical decision (Morris, 2007). …”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there has been a rising demand to increase the diagnostic effectiveness of this test through appropriate screening (Pennycook, 1995; Miyakis et al , 2006; Hawkins, 2007). With the advent of point-of-care testing, there are a few devices that measure single primary parameters such as WBC or haemoglobin accurately by a minute capillary (finger prick) sample (Morris, 2007; Osei-Bimpong et al , 2009). Supporting such appropriate developments could represent opportunities for laboratory medicine to help influence the scope of future service delivery (Beastall, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Supporting such appropriate developments could represent opportunities for laboratory medicine to help influence the scope of future service delivery (Beastall, 2008). Testing for specific individual parameters on such devices is usually very quick with results obtained within minutes, and such testing is also low in cost (Morris, 2007; Osei-Bimpong et al , 2009). The utility of an individual parameter such as the WBC or the haemoglobin, however, offers a limited and partial picture in the diagnosis (Kho et al , 2007).…”

Section: Introductionmentioning

confidence: 99%

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The use of the white cell count and haemoglobin in combination as an effective screen to predict the normality of the full blood count

Osei-Bimpong

McLean

Bhonda

et al. 2011

Int J Lab Hematology

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IntroductionThe utility of the full blood count (FBC) is vast with each parameter serving as a tool to aid diagnosis and monitor disease progression. However, the effectiveness of the test is hampered because of increased workload and lack of interpretation. In the effort to redress this issue, the combined use of the white blood cell count (WBC) and haemoglobin in predicting the normality of the FBC is evaluated.MethodFBC data were collated from 2191 patients and classified into two groups depending on whether the WBC and the haemoglobin were within the reference range. Blood films were examined on the abnormal FBC samples in each group and graded on morphology.ResultsThe FBC was normal in 89.6% of cases in the presence of a normal WBC and haemoglobin with subtle abnormalities in the remainder; 1+ grading of abnormal morphology in 93%. However, when the WBC and/or haemoglobin was abnormal, the remaining FBC was significantly abnormal (P < 0.05) and the corresponding blood films were grossly abnormal; 2+/3+ grading in 96% of cases.ConclusionWe concluded that in the presence of a normal WBC and haemoglobin, the FBC is normal in almost all cases and measuring these two parameters could be used as an effective screen to predict FBC normality.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The use of the white cell count and haemoglobin in combination as an effective screen to predict the normality of the full blood count

Osei-Bimpong

McLean

Bhonda

et al. 2011

Int J Lab Hematology

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“…A study by Morris et al55 evaluated the performance, reproducibility and accuracy of HemoCue 301+ (HemoCue AB, Angelholm, Sweden) for donor Hb measurement. The device is a modified version with cheaper reagent-free cuvettes, which are claimed to show no deterioration even in adverse climate.…”

Section: Methods For Hb Estimation In Blood Donorsmentioning

confidence: 99%

Techniques used for the screening of hemoglobin levels in blood donors: current insights and future directions

Chaudhary¹,

Sonker²

2017

JBM

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Blood donor hemoglobin (Hb) estimation is an important donation test that is performed prior to blood donation. It serves the dual purpose of protecting the donors’ health against anemia and ensuring good quality of blood components, which has an implication on recipients’ health. Diverse cutoff criteria have been defined world over depending on population characteristics; however, no testing methodology and sample requirement have been specified for Hb screening. Besides the technique, there are several physiological and methodological factors that affect accuracy and reliability of Hb estimation. These include the anatomical source of blood sample, posture of the donor, timing of sample and several other biological factors. Qualitative copper sulfate gravimetric method has been the archaic time-tested method that is still used in resource-constrained settings. Portable hemoglobinometers are modern quantitative devices that have been further modified to reagent-free cuvettes. Furthermore, noninvasive spectrophotometry was introduced, mitigating pain to blood donor and eliminating risk of infection. Notwithstanding a tremendous evolution in terms of ease of operation, accuracy, mobility, rapidity and cost, a component of inherent variability persists, which may partly be attributed to pre-analytical variables. Hence, blood centers should pay due attention to validation of test methodology, competency of operating staff and regular proficiency testing of the outputs. In this article, we have reviewed various regulatory guidelines, described the variables that affect the measurements and compared the validated technologies for Hb screening of blood donors along with enumeration of their merits and limitations.

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“…The HgB levels of the children were measured using HemoCue® HB 301, a U.S. Food and Drug Administration (FDA)-approved device designed for quick analysis of HgB in capillary, venous, or arterial blood [38][39][40][41]. As recommended by the WHO for STH surveys, we conducted stool tests on samples from 12-months to 6-yearold children from the Berd region [42].…”

Section: Measurementsmentioning

confidence: 99%

Prevalence and determinants of stunting in a conflict-ridden border region in Armenia - a cross-sectional study

Balalian

Simonyan²,

Hekimian

et al. 2017

BMC Nutr

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Background: Despite global efforts, stunting remains a public health problem in several developing countries. The prevalence of stunting among 0-to 5-year-old children in Armenia has increased from 17% in 2000 to 19% in 2010. A baseline study was conducted among preschool children in Berd, a region near the northeastern border of Armenia that has experienced intermittent military tension for over 20 years. Methods: We conducted a cross-sectional study including 594 children aged 6-month-6 years old and their caregivers in our analysis, to assess the prevalence and determinants of stunting. We calculated the anthropometric measurements and hemoglobin levels of children; analyzed children's stool and conducted a survey with children's caregivers. We employed the hierarchical logistic regression model to explore the predictors of stunting among 25-72 months old children and multivariable logistic regression models to investigate the predictors of stunting among 6-24 months old children. Individual and residence level variables were included in the models including anemia, minimum dietary diversity, mothers' height, the overall duration of breastfeeding, birthweight, child's history of diarrhea and mean socio-economic score. Results: The prevalence of stunting was significantly higher among the 6-24 months old children (13.3%) compared to the children aged 25-72 months old (7.8%). We did not find any differences in the prevalence of stunting by place of residence in either age group. The 6-24 months old children who consumed at least four food groups during the previous day (minimum dietary diversity) had 72% lower odds of being stunted (p < 0.05). Each kilogram increase in birthweight was associated with 76% lower odds of being stunted (OR = 0.24, p < 0.01). Mother's height significantly decreased the odds of stunting among the children 25-72-months old (OR = 0.86, p < 0.001). BMI was also a significant predictor of stunting among both age-groups. Conclusions: The study results highlight the significance of mother's height, birthweight, and adequate complementary feeding to reduce stunting. Further studies are needed to determine the possible association of anemia and stunting with the ongoing conflict in the region, as well as socioeconomic conditions and food insecurity in the region.

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Evaluation of the utility of the HemoCue 301 haemoglobinometer for blood donor screening

Cited by 41 publications

References 7 publications

The use of the white cell count and haemoglobin in combination as an effective screen to predict the normality of the full blood count

The use of the white cell count and haemoglobin in combination as an effective screen to predict the normality of the full blood count

Techniques used for the screening of hemoglobin levels in blood donors: current insights and future directions

Prevalence and determinants of stunting in a conflict-ridden border region in Armenia - a cross-sectional study

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