Evaluation of the Usefulness of the Portable Device Lactate Pro for Measurement of Lactate Concentrations in Equine Whole Blood

Oldruitenborgh‐Oosterbaan, M.M. Sloet van; Broek, E. T. W. Van den; Spierenburg, Astrid J.

doi:10.1177/104063870802000117

Cited by 32 publications

(22 citation statements)

References 9 publications

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“…Lactate measurements on whole blood samples were performed within 5 minutes of blood collection using the Lactate Pro blood lactate test meter and test strips . This device has been validated for measuring blood lactate concentration in horses . Lactate concentrations <0.8 mmol/L read as “low” and were assigned a value of 0.7 mmol/L for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Mizen¹,

Woodman²,

Boysen

et al. 2016

Veterinary Internal Medicne

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BackgroundBlood lactate concentration is a marker of tissue perfusion and helps guide therapeutic interventions in critically ill horses. In both humans and dogs, administration of corticosteroids can increase blood lactate concentration, leading to type B hyperlactatemia. This effect could be a consequence of the impact of corticosteroids on glucose metabolism.ObjectivesTo investigate the effects of daily IM dexamethasone administration on blood lactate and glucose concentrations in horses.AnimalsNine healthy adult horses.MethodsA randomized, blinded, controlled, cross‐over study design was used. Horses were randomly assigned to 1 of 2 groups, either receiving 0.05 mg/kg of dexamethasone IM or an equivalent volume of saline, daily for 7 days. Blood was collected to determine lactate and glucose concentrations at baseline, 2 hours after the daily injections and 24 hours after the last injection.ResultsDexamethasone treatment had a statistically significant effect on lactate (P = .006) and glucose (P = .033) concentrations. The least squares mean lactate concentration was 0.93 mmol/L (95% CI: 0.87–0.99) in the dexamethasone group compared to 0.71 mmol/L (95% CI: 0.70–0.73) for the saline group. A positive relationship between blood lactate and glucose concentrations was identified, with a 0.07 mmol/L (95% CI: 0.05–0.09) increase in lactate concentration per unit increase in glucose (P < .0001) concentration.Conclusions and Clinical ImportanceDexamethasone induces statistically significant increases in blood lactate and glucose concentrations in healthy horses. Awareness of the potential for corticosteroids to induce type B hyperlactatemia might be important in the management of critically ill horses receiving dexamethasone.

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Section: Methodsmentioning

confidence: 99%

Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Mizen¹,

Woodman²,

Boysen

et al. 2016

Veterinary Internal Medicne

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“…Plasma lactate concentration was measured using a portable instrument (Lactate Pro™)within 15 minutes after collection. The device has been shown to be accurate in equine blood assay (Sloet et al 2008). …”

Section: Set Upmentioning

confidence: 99%

Swimming exercise and race performance in Thoroughbred racehorses

Klomp¹,

Munsters²,

Oldruitenborgh‐Oosterbaan³

2014

PHK

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Swimming has become an accepted part of the training programme of race horses. The purpose of this study was to establish whether it was possible to perform a standardized swimming test in race horses and to evaluate whether exercise variables calculated from this test were related to race track performance. Fifty-two Thoroughbred racehorses (4.6 ±1.4 years; 50 geldings and 2 stallions) participating in races at the Hong Kong Jockey Club (HKJC), were used in the study. All horses underwent a swimming test consisting of two laps of an oval shaped swimming pool (1 lap = ±60 m). During the swimming test, heart rate (HR; beats/min) and speed (V; m/s) of the horses were monitored. Additionally, 10 of the 52 horses were tested a second time (after 1 -21 days), to evaluate the repeatability of the swimming test and after the second swimming test plasma lactate concentration (LA; mmol/L) was estimated. 'Performance Rating' of horses was defined by the rating score determined by the HKJC, based upon race performance. For a second performance parameter ('Performance Category'), horses were divided into 'good performers' (placed in 1 to 5 rank at competition in the period between 1 month before to 1 month after the swimming test) and 'average performers' (placed at lower rankings). Mean HR during the first swimming test was 178 ±14 bpm, the mean V was 1.06 ± 0.10 m/s. There was a significant correlation between HR and V (r = 0.720, P < 0.001, n = 52), but HR was not repeatable between tests (r = 0.390, P = 0.265, n =10). No significant correlation was found between racing performance and heart rate, speed or plasma lactate concentration. Under the existing circumstances it was not possible to perform a repeatable standardised swimming test. The results of the swimming test were not a useful predictor of either Performance Rating or Performance Category. Some horses reached high heart rates during the swimming test and one horse also showed a plasma lactate concentration above anaerobic threshold, indicating that the exercise of swimming may not be always as mild as some trainers think.Keywords: swimming test / performance / heart rate / speed / Thoroughbred racehorse / exercise physiology Schwimmtraining und Rennleistung beim Vollblut-RennpferdSchwimmen hat sich zur anerkannten Trainingsmethode für Rennpferde entwickelt. Ziel dieser Studie was es festzustellen, ob es beim Rennpferd möglich ist, einen standardisierten Schwimmtest durchzuführen und zu prüfen, ob die Leistungsvariablen aus diesem Test zu der Rennleistung auf der Bahn in Beziehung gesetzt werden können. 52 Rennpferde (4.6 ±1.4 Jahre; 50 Wallache und 2 Hengste), die im Hongkong Jockey Club (HKJC) im Rennen standen, nahmen an der Studie teil. Alle Pferde wurden einem Schwimmtest unterzogen, der in zwei Runden in einem ovalen Pool (1 Runde = 60 m) bestand. Während des Tests wurden Herzfrequenz (HR, bpm) und Geschwindigkeit (V, m/s) der Pferde aufgezeichnet. Zusätzlich wurden 10 der 52 Pferde nach 1 -21 Tagen ein zweites Mal getestet, um die Wiederholbar...

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“…Lactate can be measured using several portable devices which use dry chemistry and one such device (Lactate Pro) 1 has been shown to be reliable for blood lactate measurements in horses (Sloet van Oldruitenborgh‐Oosterbaan et al . 2008).…”

Section: Introductionmentioning

confidence: 99%

The usability of peritoneal lactate concentration as a prognostic marker in horses with severe colic admitted to a veterinary teaching hospital

Boom

Butler

Oldruitenborgh‐Oosterbaan

2010

Equine Veterinary Education

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Summary Colic can be a life‐threatening condition in horses and there is a need for parameters that can help determine the prognosis and need for surgery. The aim of the study was to investigate whether peritoneal fluid (PF) lactate concentration is useful for this purpose in horses with severe colic presented to a veterinary hospital. During a 16 month period, the peritoneal fluid (PF) lactate concentration was measured in 74 of 760 colic horses admitted to the Utrecht University equine clinic using a portable analyser. When comparing survivors and nonsurvivors, heart rate, PF and blood lactate concentrations and blood glucose concentration were significantly higher in horses that did not survive. No horse with a PF lactate concentration >9.4 mmol/l survived. The presence of a strangulating lesion was also significantly associated with nonsurvival, as was PF colour: no horse with red PF survived in the present series. In horses with yellow PF, the blood glucose concentration was correlated with the presence of a strangulating intestinal lesion. Peritoneal lactate concentrations can be easily and rapidly measured using a portable analyser and may be useful in assessing the prognosis and/or need for surgery in equine colic cases.

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Evaluation of the Usefulness of the Portable Device Lactate Pro for Measurement of Lactate Concentrations in Equine Whole Blood

Cited by 32 publications

References 9 publications

Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses

Swimming exercise and race performance in Thoroughbred racehorses

The usability of peritoneal lactate concentration as a prognostic marker in horses with severe colic admitted to a veterinary teaching hospital

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