2021
DOI: 10.1016/j.meegid.2021.105009
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Evaluation of the usefulness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine in a context with increased resistance of Plasmodium falciparum in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo

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Cited by 11 publications
(8 citation statements)
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References 55 publications
(101 reference statements)
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“…In this study, A437G was the most prevalent point mutation (83.33%; 190/228) in Pfdhps in the majority of the countries in central Africa, except for Chad and the Central African Republic, where there was a higher proportion of the S436A mutation than the A437G mutation. Regarding K540E, the prevalence in Angola (6.38%) from our data was consistent with previously reported results (7%) ( 22 ), while the frequency in Congo DR (27.27%) was lower than those in previous reports (~32.6% to >50%) ( 27 , 28 ). These findings demonstrate the spatial heterogeneity of Pfdhps point mutations in central African countries.…”
Section: Discussionsupporting
confidence: 92%
“…In this study, A437G was the most prevalent point mutation (83.33%; 190/228) in Pfdhps in the majority of the countries in central Africa, except for Chad and the Central African Republic, where there was a higher proportion of the S436A mutation than the A437G mutation. Regarding K540E, the prevalence in Angola (6.38%) from our data was consistent with previously reported results (7%) ( 22 ), while the frequency in Congo DR (27.27%) was lower than those in previous reports (~32.6% to >50%) ( 27 , 28 ). These findings demonstrate the spatial heterogeneity of Pfdhps point mutations in central African countries.…”
Section: Discussionsupporting
confidence: 92%
“…The WHO recommends that SP should continue to be used for IPTp in areas of SP resistance [ 35 , 36 ]. However, another recent study found that IPTp with SP in areas with high prevalence of SP resistance markers was not associated with reduced maternal malaria although the there was evidence of prophylactic effect against adverse pregnancy outcomes [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, in DRC, IPTp3+ implementation is less than the universal coverage and the majority of women attending at least four antenatal care visits receive less than three doses of IPTp [ 1 , 98 ]. Despite the increase in SP falciparum resistance in DRC [ 99 , 100 , 101 , 102 , 103 , 104 ], IPTp is still used for malaria prevention during pregnancy and protection against maternal anemia and low birthweight; especially when it is given in three or more doses [ 101 ], as shown in other countries [ 105 , 106 , 107 , 108 , 109 ].…”
Section: Current Drc Malaria Control Policymentioning
confidence: 99%