Evaluation of the use of tranexamic acid in total knee arthroplasty

Abstract

ObjectiveEvaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty.Methods101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.ResultsComparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.ConclusionThe use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.

Efficacy and Safety of Tranexamic Acid in Total Knee Replacement Surgeries: A Randomized Control Trial

“…9 Almeida et al evaluated the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty in a triple blinded study prospective randomised controlled study and found that despite their study group having significant lower hemoglobin and hematocrit levels (in the preoperative period) than the control group, the fall in hemoglobin and blood loss was significantly more in the control group. 10 Vijay et al studied the role of tranexamic acid in the context of a pharmacological agent to reduce postoperative blood loss and transfusion requirements in patients undergoing hip and femoral surgeries and concluded that administration of tranexamic acid preoperatively reduced the blood loss in the first 24 hours by highly significant degree in patients undergoing surgeries for hip and femoral fractures. 11 In a review article titled "Tranexamic acid and orthopaedic surgery-the search for the holy grail of blood conservation", Danninger et al have analysed major trials on tranexamic acid use in orthopaedic surgeries and concluded that there is substantial evidence suggesting tranexamic acid is effective in reducing blood loss and the need for blood transfusion in orthopedic surgeries involving joints.…”

Artroplastia total do joelho com ou sem isquemia: o uso otimizado do torniquete em um estudo comparativo, prospectivo e randomizado

“…3 x 0,356 + peso (Kg) x 0,33 + 0,183 Parecer Consubstanciado do CEP O estudo foi dividido em 2 subprojetos, onde no primeiro focamos na avaliação clínica e perda sanguínea e no segundo no comprometimento muscular causado pela isquemia induzida pelo torniquete.…”