Evaluation of the Use of a Biodegradable Ureteral Stent After Retrograde Endopyelotomy in a Porcine Model

Olweny, Ephrem O.; Landman, Jaime; Andreoni, Cássio; Collyer, William C.; Kerbl, Kurt; Onciu, Mikhaila; V??LIMAA, TERO; Clayman, Ralph V.

doi:10.1097/00005392-200205000-00071

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…At physiological diuresis rates this extra‐luminal flow is mainly responsible for urine drainage 17–19. Since a ureteral stent abolishes ureter peristalsis,20, 21 the extra‐luminal flow rate alongside a 7 Ch stent clearly exceeds the intra‐luminal flow 22, 23. On this account, several lumen‐less stent types were successfully field‐tested and are now available on the market.…”

Section: Discussionmentioning

confidence: 99%

The distribution of crystalline material in obstructed stents—In need for intra‐luminal surface modification?

Laube¹,

Kleinen²,

Avrutin³

et al. 2008

J Biomed Mater Res

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Section: Discussionmentioning

confidence: 99%

The distribution of crystalline material in obstructed stents—In need for intra‐luminal surface modification?

Laube¹,

Kleinen²,

Avrutin³

et al. 2008

J Biomed Mater Res

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“…The development of biodegradable ureteral stents has been pursued previously. However, regardless of early positive results with various models, [9][10][11][12] these attempts were abandoned due to biocompatibility issues in porcine ureters 13 or because they degraded in inhomogeneous, premature, or delayed fashion. 14,15 Hydrogels can be applied as a coating surface modification to ureteral stents.…”

Section: Introductionmentioning

confidence: 99%

Bioresorbable ureteral stents from natural origin polymers

Barros

Rita²,

Duarte

et al. 2014

J Biomed Mater Res

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In this work, stents were produced from natural origin polysaccharides. Alginate, gellan gum, and a blend of these with gelatin were used to produce hollow tube (stents) following a combination of templated gelation and critical point carbon dioxide drying. Morphological analysis of the surface of the stents was carried out by scanning electron microscopy. Indwelling time, encrustation, and stability of the stents in artificial urine solution was carried out up to 60 days of immersion. In vitro studies carried out with simulated urine demonstrated that the tubes present a high fluid uptake ability, about 1000%. Despite this, the materials are able to maintain their shape and do not present an extensive swelling behavior. The bioresorption profile was observed to be highly dependent on the composition of the stent and it can be tuned. Complete dissolution of the materials may occur between 14 and 60 days. Additionally, no encrustation was observed within the tested timeframe. The ability to resist bacterial adherence was evaluated with Gram‐positive Staphylococcus aureus and two Gram‐negatives Escherichia coli DH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differences were observed in comparison with a commercial stent (Biosoft® duo, Porges), although, for S. aureus all tested compositions had a higher inhibition of bacterial adhesion compared to the commercial stents. In case of E. coli, the addition of gelatin to the formulations reduced the bacterial adhesion in a highly significant manner compared to the commercial stents. The stents produced by the developed technology fulfill the requirements for ureteral stents and will contribute in the development of biocompatible and bioresorbable urinary stents. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 608–617, 2015.

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“…Also, stent fragments have been shown to occasionally have an obstructive nature, requiring extra procedures to remove undegraded stent fragments. 10,11 The current comparative experimental study shows that the biodegradable ureteral stents meet the main objective of bs_bs_banner Evaluation of a novel ureteral stent…”

Section: Conflict Of Interestmentioning

confidence: 91%

“…[6][7][8][9] Numerous biodegradable ureteral stents have been studied to date; however, most of them have not been made commercially available because of their poor biocompatibility or inappropriate degradation. [10][11][12] We designed a braided thin-walled biodegradable ureteral stent made of PGA and PLGA multifilaments. Using textile techniques, stents with the same outer diameter could be fabricated with a thinner wall and higher internal/external diameter ratio for improved drainage.…”

Section: Introductionmentioning

confidence: 99%

Braided thin‐walled biodegradable ureteral stent: Preliminary evaluation in a canine model

et al. 2013

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Abbreviations & AcronymsObjectives: To evaluate a novel designed degradable ureteral stent. Methods: A total of 24 male Beagles, each with bilateral stents implanted (a biodegradable ureteral 4.5-Fr stent and a standard 4-Fr biostable stent) were divided into four groups. Intravenous pyelography, B-mode ultrasonography, and blood and urine tests were carried out before the procedure (0 weeks), and at 1-, 2-, 3-and 4-week intervals. Meanwhile, the mechanical characteristics of stents were tested, and scanning electron microscopy images of the biodegradable braided stents were obtained at different time-points postoperatively. In addition, histopathological changes were compared between the two different stents. Results: All biodegradable braided stents began degrading at 1 week, and had completely degraded by 4 weeks. Hydronephrosis was equivalent during the first 2 weeks, but less with the biodegradable stents than with the control biostable stents at 3 and 4 weeks. Preoperative and postoperative blood and urine results were similar. The mechanical properties of the biodegradable stents were better than conventional biostable stents. Scanning electron microscopy images obtained at different weekly intervals showed that stents degraded in a predictable fashion. Histological testing of the urinary tract showed that the stent-related tissue reactivity of the two different stents were similar. Conclusions: Our novel braided thin-walled biodegradable stents provide temporary renal drainage as good as commercially available biostable stents. They also have good biocompatibility and physical characteristics. Therefore, they might have clinical application.

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Evaluation of the Use of a Biodegradable Ureteral Stent After Retrograde Endopyelotomy in a Porcine Model

Abstract: In this pilot study the use of self-reinforced PLGA biodegradable ureteral stents was feasible after Acucise endopyelotomy in a porcine model with radiographic and fluid flow results that were relatively similar to those of standard 7Fr stents but with less favorable biocompatibility.

Cited by 9 publications

References 13 publications

The distribution of crystalline material in obstructed stents—In need for intra‐luminal surface modification?

The distribution of crystalline material in obstructed stents—In need for intra‐luminal surface modification?

Bioresorbable ureteral stents from natural origin polymers

Braided thin‐walled biodegradable ureteral stent: Preliminary evaluation in a canine model

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