Evaluation of the turning characteristics according to the severity of Parkinson disease during the timed up and go test

Son, Moon; Youm, Changhong; Cheon, Sang-Myung; Kim, Jae-Woo; Lee, Meounggon; Kim, Youkyung; Kim, Jinhee; Sung, Hyeryun

doi:10.1007/s40520-016-0719-y

Cited by 44 publications

(43 citation statements)

References 31 publications

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“…Turning difficulty is common among people with PD in advanced stages. People with PD turn slowly with prominent small steps, even demonstrating gait disturbances such as freezing of gait (20)(21)(22)(23). But our study has shown that there is a problem of turning in mild to moderate Parkinson's disease.…”

Section: Discussionmentioning

confidence: 56%

Turning Performance and Factors Related to Turning in Mild And Moderate Phase Parkinson’s Disease Patients

2018

IJOAR

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Background/aim: The purpose of study is to determine the turning performance and other factors related to turning in mild and moderate phase Parkinson's disease patients (PD). Methods: Ninety two patients were followed up for observation. After passing neurological examinations, the Unified Parkinson Disease Rating Scale (UPDRS), Hoehn / Yahr Scale (H&Y), Mini Mental State Examination (MMSE), Tinetti test, Berg Balance test, 6 m walking test, step count, 360° turning duration, and Functional Independence Measure (FIM) were applied. All cases were evaluated according to the "on" period. Results: Forty one females and 51 males participated in the study. The duration of time it took to turn right was 8.22 ± 6.26 seconds, and the time it took to turn from left was 8.51 ± 6.63 sec. There appeared to be no statistical difference in the turn times of patients either in terms of the socioeconomic factors of gender, education level, or employment status. But, statistically significant relationships were found when it came to in both directions, age, duration of illness, UPDRS, FIM, Tinetti, the Berg Test, the walking test, and the number of steps taken. Conclusion: Our results suggest that 360 degree turning performance in mild and moderate stage PD is strongly associated with patient's age, disease duration and disease severity.

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Section: Discussionmentioning

confidence: 56%

Turning Performance and Factors Related to Turning in Mild And Moderate Phase Parkinson’s Disease Patients

2018

IJOAR

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“…Additionally, there was no relationship between ALFF values in right lingual gyrus and TUG test time or PIGD scores in the PD‐GG group. TUG test can be used to evaluate the walking or turning characteristics and predict fall risks in PD . Besides, PIGD scores from UPDRS‐III scores can also reflect gait or balance function in PD patients to some extent.…”

Section: Discussionmentioning

confidence: 99%

“…Lingual gyrus, located in occipital cortex (also known as visual association cortex), participated in spatial orientation 39 and visuospatial information processing. 40,41 Moreover, changes in the flow of visual information mainly dominated by right hemisphere, 42,43 had an influence on balance disorders 44 48 and predict fall risks in PD. 49,50 Besides, PIGD scores from UPDRS-III scores can also reflect gait or balance function in PD patients to some extent.…”

Section: Discussionmentioning

confidence: 99%

BST1 rs4698412 allelic variant increases the risk of gait or balance deficits in patients with Parkinson’s disease

Shen

Wang

et al. 2019

CNS Neurosci Ther

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Summary Aims We aimed to explore effects of bone marrow stromal cell antigen‐1 (BST1) rs4698412 allelic variant on brain activation and associative clinical symptoms in Parkinson’s disease (PD). Methods A total of 49 PD patients and 47 healthy control (HC) subjects were recruited for clinical evaluations, blood samples collection for genotypes, and resting‐state functional MRI (rs‐fMRI) scans. Based on BST1 rs4698412 allelic variant (G → A), participants were further divided into 18 PD‐GG, 31 PD‐GA/AA, 20 HC‐GG, and 27 HC‐GA/AA carriers, which respectively indicated subjects carrying ancestral or risk allele in that locus in PD or HC. Two‐way analysis of covariance (ANCOVA) was applied to investigate main effects and interactions between PD and BST1 rs4698412 allelic variant on brain function via amplitude of low‐frequency fluctuations (ALFF). Spearman’s correlations were then utilized to detect associations between interactive brain regions and clinical symptoms. Results Compared to HC subjects, PD patients exhibited increased ALFF values in left cerebellum_8 and cerebellum_9. Significant interaction was in right lingual gyrus, where there were the lowest ALFF values and ALFF values were only negatively associated with Timed Up and Go (TUG) test time in PD‐GA/AA subgroup. Conclusion BST1 rs4698412‐modulated lingual gyrus functional alterations could be related to gait and balance dysfunction in PD.

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“…People with PD turn slowly with prominent small steps, even demonstrating gait disturbances such as freezing of gait. [20][21][22][23] But study has shown that there is a problem of turning in mild to moderate Parkinson's disease. It also showed that in these patients, the ability to turn was associated with age, duration of illness, UPDRS, FIM, Tinetti walking-balance, the Berg balance, 6m walking time, and the number of steps taken.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of gait problems and related factors in patients with Parkinson’s disease

Soyuer

Gültekın

Cankurtaran

2018

IJFCM

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Evaluation of the turning characteristics according to the severity of Parkinson disease during the timed up and go test

Abstract: Patients with PD exhibited significant differences in all variables of interest compared to the controls. The step length and foot clearance height as well as the TUG test during the turning phase may be helpful for measuring turning in patients with different severity levels of PD.

Cited by 44 publications

References 31 publications

Turning Performance and Factors Related to Turning in Mild And Moderate Phase Parkinson’s Disease Patients

Turning Performance and Factors Related to Turning in Mild And Moderate Phase Parkinson’s Disease Patients

BST1 rs4698412 allelic variant increases the risk of gait or balance deficits in patients with Parkinson’s disease

The evaluation of gait problems and related factors in patients with Parkinson’s disease

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