Evaluation of the Toxic Effect of Bauhinia purpurea Mediated Synthesized Silver Nanoparticles against In-vitro and In-vivo Models

Abstract

Metal nanoparticles, such as gold nanoparticles, silver nanoparticles, etc., have many benefits and have been in use for a very long time. Nevertheless, a number of concerns have been raised about the environmental impact and the possibility of exposure to various living systems at the moment. Thus, in this study, silver nanoparticles were synthesized by using plant gum from Bauhinia purpurea and characterization was done using UV—Visible Spectroscopy, Scanning Electron Microscopy, X—ray Diffraction, etc. To determine the accumulation and toxic effects caused by the nanoparticles, Eudrilus eugeniae, Danio rerio, and their embryos were exposed to the synthesized silver nanoparticles and evaluated using microscopic observation, histology, and Inductively Coupled Plasma Optical Emission Spectrometry (ICP—OES).

Assessment on the Toxic Effects of Chemically Synthesized SPIONs against Model Organisms

“…SPIONs are reported to cause oxidative stress responses such as inflammation, damage to the membrane, denaturation of protein, mitochondriamediated apoptosis, lipid peroxidation, genotoxicity, etc. [41,42]. Low level of oxidative stress activates the genes responsible for transcription defense through transcription factor, leading to the activation of inflammation and apoptosis, and necrosis [43].…”