Evaluation of the ThinPrep Processor for Fine Needle Aspiration Specimens

Lee, Kenneth R.; Papillo, Jacalyn L.; John, Timothy St.; Eyerer, George J.A.

doi:10.1159/000333999

Cited by 76 publications

(106 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Comparing the results of breast FNA before versus after the introduction of AMAPS, the rate of unsatisfactory specimens was significantly lower using AMAPS (8.8%) than with AutoSmear (16%), in agreement with a previous study of a liquid-based preparation method [7]. This advantage is largely due to a better and consistent cell recovery rate, as shown in this study.…”

Section: Discussionsupporting

confidence: 91%

“…These disadvantages have been partly overcome using special glass slides facilitating superior adhesion of nonepithelial cells and noncellular elements. [7]. In our study, the diagnosis of benign lesions was superior with AMAPS than with AutoSmear, resulting in a decreased incidence of surgical excision for benign lesions.…”

Section: Discussionmentioning

confidence: 58%

“…LBC systems, in which cells are recovered and fixed in a solution prior to application onto the slide, are reported to have advantages compared with the conventional method, including clear background, monolayer cell preparation and cell preservation, as well as simple preparation and shorter time for screening and interpretation of cells [7,8]. In addition, preserved cells can be utilized for both additional diagnostic examinations and research employing various techniques, including molecular analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Lee et al [7] reported slightly better sensitivity and specificity levels using ThinPrep specimens compared with conventional smears of aspiration cytology for various organs, including the breast. Biscotti et al [13] compared ThinPrep and conventional smears from surgically excised breast masses and showed similar sensitivity of ThinPrep smears and conventional smears in the diagnosis of carcinomas, but a lower specificity with ThinPrep, though statistically nonsignificant [7,13]. Our results obtained with AMAPS are as good as those obtained with currently available systems.…”

Section: Discussionmentioning

confidence: 99%

“…ThinPrep (Cytyc, Boxborough, Mass., USA) is one of the most widely used cell preparation systems [1,2,3,4,5,6]. The superiority of ThinPrep slides to conventional preparations includes clear background, monolayer cell preparation and cell preservation [7,8]. Screening and interpretation of ThinPrep preparations were also reported to be easier and less time consuming because the cells are restricted to smaller areas.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An Aspiration Material Preparation System: Application of a New Liquid-Based Cytology Technique for Fine-Needle Aspiration of the Breast

Sakakibara

Kimachi²,

Hashimoto³

et al. 2010

Acta Cytologica

View full text Add to dashboard Cite

Objective: To evaluate the usefulness of our original liquid-based cell preparation system AMAPS (aspiration material preparation system) and to compare it with the AutoSmear system in breast aspiration cytology. Study Design: A total of 487 specimens of fine-needle aspiration cytology of the breast were retrieved, of which 250 were processed with AMAPS and 237 with the AutoSmear method (before the introduction of AMAPS). A final histological diagnosis was obtained by an excisional biopsy or a surgical resection in 148 cases. Results: Cell recovery rates were significantly improved with AMAPS (96.8 and 99.1% in Papanicolaou and Diff-Quik, respectively) compared with the AutoSmear method (40.9 and 42.3%, respectively; p < 0.01). Within-run and day-to-day reproducibility of cell recovery was satisfactory, with coefficients of variations of 6.8 and 8.7%, respectively. Following the introduction of AMAPS in breast cytology, the unsatisfactory rate decreased significantly (from 16.0 to 8.8%; p < 0.01), while the diagnostic sensitivity for malignancy did not change (97.8 to 98.1%). Moreover, the diagnostic specificity for benign lesions increased from 75 to 93.8%, thus decreasing the excision rate of fibrocystic disease. Conclusion: AMAPS may serve as an alternative to the conventional technique or commercially available liquid-based cytology systems.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 58%