Evaluation of the terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the mouse chronic constriction injury model of neuropathic pain: possible cannabinoid receptor involvement

Bilbrey, Joshua A.; Ortiz, Yuma T.; Felix, Jasmine S.; McMahon, Lance Richard; Wilkerson, Jenny L.

doi:10.1007/s00213-021-06031-2

Cited by 20 publications

(20 citation statements)

References 47 publications

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“…11,26 The γ-terpinene (4.4%), another major component of CREOs, has also shown antidepressant activity in previous experiments. 27,28 Moreover, β-caryophyllene, present in lower proportion in CREOs, has also been found to significantly improve depression-like effects. 29 These findings demonstrate the potential of CREOs as an effective antidepressant.…”

Section: Resultsmentioning

confidence: 99%

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Antidepressant-Like Effect of Essential Oils FromCitrus reticulatain Reserpine-Induced Depressive Mouse

Tang¹,

Ai²,

Zhu³

et al. 2022

Natural Product Communications

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Citrus reticulata Blanco has been widely used to cure some diseases such as cold, cough and indigestion. This study is aimed at determining the antidepressant-like effect of C. reticulata essential oils (CREOs) in reserpine-induced depression mice, as well as its possible mechanisms. The compositions of CREOs are firstly analyzed by gas chromatography-mass spectrometry (GC-MS), in which d-limonene is the main component. Moreover, the results from the forced swimming and tail suspension tests show that the inhalation of CREOs can significantly improve the depressive behavior of reserpine-induced depressed mice by reducing the weight of the mice and shortening the immobile time. After sniffing CREOs, the number of normal neurons in the hippocampus of reserpine-induced depressed mice is greatly increased. In addition, CREOs significantly increase the expression level of 5-hydroxytryptamine-1A receptors (5HT-1A), glucocorticoid receptors (GR) and brain-derived neurotrophic factor (BDNF) in the reserpine-treated mice brain tissue. Thus, these results have indicated that CREOs can be potential materials for drug and food development against depression.

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Section: Resultsmentioning

confidence: 99%

“…b RIs relative to n-alkanes (C 6 -C 40 ) on the same methyl silicone capillary column. Lawal et al23 ; Espina et al24 ; Chutia et al25 ; Nengguo et al26 Corse et al27 Adelani Babarinde et al28 .…”

mentioning

confidence: 99%

Antidepressant-Like Effect of Essential Oils FromCitrus reticulatain Reserpine-Induced Depressive Mouse

Tang¹,

Ai²,

Zhu³

et al. 2022

Natural Product Communications

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“…Specifically, alpha-muurolene—belonging to the class of terpenes—in LFD T 1 was significant higher compared to the baseline. Previous evidence supported the idea that terpenes are strictly correlated to potentially beneficial implications in conditions of low inflammation, such as IBS-D [ 27 , 28 ]. In fact, it was demonstrated how the abundance of some intestinal microorganisms causing gastrointestinal infections ( Campylobacter jejuni and Clostridium difficile ), compared to others, reduces the number of some secondary metabolites (such as terpene metabolites) [ 29 ].…”

Section: Discussionmentioning

confidence: 74%

Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation

et al. 2022

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Since irritable bowel syndrome (IBS)—a common gastrointestinal (GI) disorder—still lacks effective therapy, a nutritional approach may represent a practical alternative. Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications. More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD). We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks. Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups. After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one. Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid). Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients.

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“…In this context, a differential cannabinoid receptor activity and the inhibition of glycoprotein-P [ 39 , 40 ] by terpenes have been studied and established. Moreover, many studies have demonstrated terpene enhancement of the absorption of several active pharmaceutical ingredients, such as analgesics and anti-inflammatories [ 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

Digital Technologies Applied to Control the One-Step Process of Cannabis Olive Oil Preparations

Bongiorno¹,

Lopalco

Casiraghi

et al. 2023

Pharmaceutics

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The reproducibility of an extemporaneous preparation is an essential condition for guaranteeing the quality, efficacy, and safety of the medicinal product. This study aimed to develop a controlled one-step process for cannabis olive oil preparations by applying digital technologies. For this purpose, the chemical profile of cannabinoid contents in oil extracts of Bedrocan, FM2, and Pedanios varieties obtained with the already in use method, proposed by the Italian Society of Compounding Pharmacists (SIFAP), was compared with two new methods, specifically the Tolotto Gear® extraction method (TGE) and the Tolotto Gear® extraction method preceded by a pre-extraction procedure (TGE-PE). HPLC analyses showed that the concentration of THC using cannabis flos with a high THC content (over 20% w/w) was always higher than 21 mg/mL for the Bedrocan variety and close to 20 mg/mL for the Pedanios variety when applying TGE, while with TGE-PE, the THC concentration was higher than 23 mg/mL for the Bedrocan variety. For the FM2 variety, the amounts of THC and CBD in the oil formulations obtained using TGE were higher than 7 mg/mL and 10 mg/mL, respectively, and for TGE-PE, the concentrations of THC and CBD were higher than 7 mg/mL and 12 mg/mL, respectively. GC-MS analyses were performed to define the terpene contents in the oil extracts. The samples of Bedrocan flos extracted with TGE-PE displayed a distinctive profile, highly rich in terpenes and devoid of oxidized volatile products. Thus, TGE and TGE-PE allowed performing a quantitative extraction of cannabinoids and increasing the total mono-di-tri terpenes and sesquiterpene concentrations. The methods were repeatable and applicable to any quantity of raw material, preserving the phytocomplex of the plant.

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Evaluation of the terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the mouse chronic constriction injury model of neuropathic pain: possible cannabinoid receptor involvement

Cited by 20 publications

References 47 publications

Antidepressant-Like Effect of Essential Oils FromCitrus reticulatain Reserpine-Induced Depressive Mouse

Antidepressant-Like Effect of Essential Oils FromCitrus reticulatain Reserpine-Induced Depressive Mouse

Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation

Digital Technologies Applied to Control the One-Step Process of Cannabis Olive Oil Preparations

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