Evaluation of the Swedish Colorectal Cancer Registry: an overview of completeness, timeliness, comparability and validity

Moberger, Peter; Sköldberg, Filip; Birgisson, Helgi

doi:10.1080/0284186x.2018.1529425

Cited by 129 publications

(135 citation statements)

References 19 publications

(30 reference statements)

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“…The coverage of SCRCR, compared with that of the Swedish cancer registry, where registration is compulsory, has been shown previously 38,39 to be accurate for 97-99⋅9 per cent for the different years of the study. Patient and tumour characteristics related to the primary surgical treatment included age, sex and location of tumour, TNM stage, and all known metastatic disease.…”

Section: Methodsmentioning

confidence: 94%

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

et al. 2020

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Background: Resection of the primary tumour is a prerequisite for cure in patients with colorectal cancer, but hepatic metastasectomy has been used increasingly with curative intent. This national registry study examined prognostic factors for radically treated primary tumours, including the subgroup of patients undergoing liver metastasectomy. Methods: Patients who had radical resection of primary colorectal cancer in 2009-2013 were identified in a population-based Swedish colorectal registry and cross-checked in a registry of liver tumours. Data on primary tumour and patient characteristics were extracted and prognostic impact was analysed.Results: Radical resection was registered in 20 853 patients; in 38⋅7 per cent of those registered with liver metastases, surgery or ablation was performed. The age-standardized relative 5-year survival rate after radical resection of colorectal cancer was 80⋅9 (95 per cent c.i. 80⋅2 to 81⋅6) per cent, and the rate after surgery for colorectal liver metastases was 49⋅6 (46⋅0 to 53⋅2) per cent. Multivariable analysis identified lymph node status, multiple sites of metastasis, high ASA grade and postoperative complications after resection of the primary tumour as strong risk factors after primary resection and following subsequent liver resection or ablation. Age, sex and primary tumour location had no prognostic impact on mortality after liver resection.Conclusion: Lymph node status and complications have a negative impact on outcome after both primary resection and liver surgery. Older age and female sex were underrepresented in the liver surgical cohort, but these factors did not influence prognosis significantly.

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Section: Methodsmentioning

confidence: 94%

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

et al. 2020

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“…It contains information regarding patients and tumour characteristics, preoperative staging and investigations, perioperative details, oncological treatment and postoperative 5‐year follow‐up. This register has been found to have good validity and to capture 99% of all patients diagnosed with CRC in Sweden .…”

Section: Methodsmentioning

confidence: 99%

Family history of colorectal cancer and survival: a Swedish population‐based study

et al. 2020

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Pesola F, Eloranta S, Martling A, Saraste D, Smedby KE (King's College London, ). Family history of colorectal cancer and survival: a Swedish population-based study. J Intern Med 2020; 287: 723-733. Objectives. A family history of colorectal cancer (CRC)is an established risk factor for developing CRC, whilst the impact of family history on prognosis is unclear. The present study assessed the association between family history and prognosis and, based on current evidence, explored whether this association was modified by age at diagnosis.Methods. Using data from the Swedish Colorectal Cancer Registry (SCRCR) linked with the Multigeneration Register and the National Cancer Register, we identified 31 801 patients with a CRC diagnosed between 2007 and 2016. The SCRCR is a clinically rich database which includes information on the cancer stage, grade, location, treatment, complications and postoperative follow-up.Results. We estimated excess mortality rate ratios (EMRR) for relative survival and hazard ratios (HR) for disease-free survival with 95% confidence intervals (CIs) using flexible parametric models. We found no association between family history and relative survival (EMRR = 0.96, 95% CIs: 0.89-1.03, P = 0.21) or disease-free survival (HR = 0.98, 95% CIs: 0.91-1.06, P = 0.64). However, age was found to modify the impact of family history on prognosis. Young patients (<50 at diagnosis) with a positive family history had less advanced (i.e. stages I and II) cancers than those with no family history (OR = 0.71, 95% CI: 0.56-0.89, P = 0.004) and lower excess mortality even after adjusting for cancer stage (EMMR = 0.63, 95% CIs: 0.47-0.84, P = 0.002). Conclusions.Our results suggest that young individuals with a family history of CRC may have greater health awareness, attend opportunistic screening and adopt lifestyle changes, leading to earlier diagnosis and better prognosis.

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“…The register includes data on age, gender, treatment, and postoperative follow-up. Completeness for the SCRCR is over 98% for both colon and rectal cancer, and validity compared to reabstracted data has an average agreement of 90% [17]. In addition to the SCRCR, we also used data from the National Patient Register (NPR) [18].…”

Section: Methodsmentioning

confidence: 99%

Incidence of wound dehiscence after colorectal cancer surgery: results from a national population-based register for colorectal cancer

Söderbäck

Gunnarsson

Hellman

et al. 2019

Int J Colorectal Dis

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Background Patient-related risk factors for wound dehiscence after colorectal surgery remain obscure. Methods All open abdominal procedures for colorectal cancer registered in the Swedish Colorectal Cancer Registry (SCRCR, 5) 2007-2013 were identified. Potential risk factors for wound dehiscence were identified by cross-matching between the SCRCR and the National Patient Register (NPR). The endpoint in this study was reoperation for wound dehiscence registered in either the SCRCR or NPR and patients not reoperated were considered controls. Results A total of 30,050 patients were included in the study. In a multivariable regression analysis, age > 70 years, male gender, BMI > 30, history of chronic obstructive pulmonary disease, history of generalised inflammatory disease, and duration of surgery less than 180 min were independently and significantly associated with increased risk for wound dehiscence. A history of diabetes, chronic renal disease, liver cirrhosis, and distant metastases was not associated with wound dehiscence. The hazard ratio for postoperative death was 1.24 for patients who underwent reoperation for wound dehiscence compared with that for controls. Discussion Patients reoperated for wound dehiscence face a significantly higher postoperative mortality than those without. Risk factors include male gender, age > 70 years, obesity, history of chronic obstructive pulmonary disease, and history of generalised inflammatory disease. Patients at high risk for developing wound dehiscence may, if identified preoperatively, benefit from active prevention measures implemented in routine surgical practice.

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Evaluation of the Swedish Colorectal Cancer Registry: an overview of completeness, timeliness, comparability and validity

Cited by 129 publications

References 19 publications

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer

Family history of colorectal cancer and survival: a Swedish population‐based study

Incidence of wound dehiscence after colorectal cancer surgery: results from a national population-based register for colorectal cancer

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