Evaluation of the Survival Benefit of Different Chemotherapy Regimens in Patients with T1-2N0 Triple-Negative Breast Cancer

Kim, Hyun Ah; Seong, Min Ki; Kim, Eun Kyu; Kang, Eunyoung; Park, Seho; Hur, Min; Song, Byung Joo; Noh, Woo Chul

doi:10.4048/jbc.2015.18.3.271

Cited by 14 publications

(11 citation statements)

References 27 publications

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“…Short-interval, frequent follow-up sessions may be helpful for early detection of relapse. Intensified adjuvant treatment for overweight patients, including combination CT ( 23 24 ) and dose-escalated RT ( 25 ), can be attempted as treatment options to improve outcomes. In cases with clinically suspected recurrence, active and immediate diagnostic evaluation and treatment should be performed.…”

Section: Discussionmentioning

confidence: 99%

Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection

et al. 2016

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This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m2, range 17.2–31.6 kg/m2): 31 patients (62%) were classified as being overweight or obese (BMI ≥ 23 kg/m2) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m2). The median follow-up for patients was 31.1 months (range, 6.7–101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients.

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Section: Discussionmentioning

confidence: 99%

Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection

et al. 2016

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“…Most patients with advanced-stage breast cancer received chemotherapy, which was performed in 84.1% (n = 53) of the patients with standard treatment regimens, of which 6 received neoadjuvant chemotherapy before surgical resection. Anthracycline- and taxane-based regimens were commonly used in chemotherapy [ 11 ]. Most patients who underwent BCS received adjuvant RT.…”

Section: Methodsmentioning

confidence: 99%

Lymphovascular invasion as a negative prognostic factor for triple-negative breast cancer after surgery

2017

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PurposeThis study aimed to evaluate the prognostic effects of lymphovascular invasion (LVI) in triple-negative breast cancer (TNBC) patients who underwent surgical resection.Materials and MethodsA total of 63 non-metastatic TNBC patients who underwent surgical resection were retrospectively investigated from 2007 to 2016 in Inje University Busan Paik Hospital. Pathological tests revealed that 12 patients (19.0%) had LVI. Approximately 61.9% (n = 39) of the patients’ samples stained positive for p53. Additional chemotherapy and radiotherapy (RT) were performed in 53 (84.1%) and 47 (74.6%) patients, respectively.ResultsThe median follow-up period was 39.5 months (range, 5.9 to 123.0 months). The pathological T stage (p = 0.008), N stage (p = 0.014), and p53 positivity (p = 0.044) were associated with LVI. Overall, the 3-year disease-free survival (DFS) rate and overall survival (OS) rate were 85.4% and 90.2%, respectively. Ten patients (15.9%) experienced relapse. LVI (n = 12) was associated with relapses (p = 0.016). p53 positivity was correlated with poor DFS (p = 0.048). Furthermore, LVI was related to poor DFS (p = 0.011) and OS (p = 0.001) and considered as an independent prognostic factor for DFS (p = 0.039). The 3-year DFS of patients with LVI (n = 12) was only 58.3%. Adjuvant RT minimized the negative prognostic effect of LVI on DFS (p = 0.068 [with RT] vs. p = 0.011 [without RT]).ConclusionLVI was related to the detrimental effects of disease progression and survival of TNBC patients. Thus, a more effective treatment strategy is needed for TNBC patients with LVI.

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“…However, other studies have shown that standard adjuvant chemotherapy regimens improve overall survival in TNBC patients, for example, patients with T1/2 node-positive TNBC. 10 Possible limitations to this study should be considered. As this was a retrospective study, follow-up times varied widely.…”

Section: Discussionmentioning

confidence: 98%

“…9 Therapeutic options for TNBC are limited to non-targeted therapies due to a lack of an identified molecular target. 10 Breast conservation surgery is an option for early breast cancer followed by adjuvant radiation therapy; recent reviews suggest that, after adjusting for age at diagnosis, stage, histology and grade, survival was equal or better after breast conservation surgery than mastectomy. 9,11 Conventional radiation treatment involves whole-breast tangential irradiation over 5 weeks, with a subsequent boost to the tumor bed 12 where indicated due to tumor and patient characteristics.…”

Section: Introductionmentioning

confidence: 99%

<p>Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients</p>

Wen¹,

Manuel²,

Doolan³

et al. 2020

BCTT

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Purpose: Triple negative breast cancer (TNBC) accounts for approximately 15% of breast cancer cases and is associated with a poor prognosis. In this retrospective study of patients undergoing radiation therapy as part of their treatment, disease-free survival (DFS) and overall survival (OS) of TNBC patients were examined in relation to clinical and treatmentrelated factors. Patients and Methods: The electronic records of 214 consecutive TNBC patients treated with surgery followed by radiotherapy at the Mid North Coast Cancer Institute between 2006 and 2016 were reviewed. Overall survival and DFS times were analyzed using the Kaplan-Meier method; multivariate Cox proportional hazard regression modelling was used to assess the significance of prognostic factors. Results: The majority of tumors were T1 (51.9%), followed by T2 (39.2%) and T3 (6.1%). For the whole group, mean DFS was 106.4 (SD 48.7) months; OS 109.4 (SD 52.1) months. Radiotherapy technique, fractionation protocol and laterality were not significant factors for DFS or OS (p>0.05). However, compared to breast conservation, mastectomy was associated with poorer DFS (mean 114.2 vs 65.2 months; p<0.0001) and poorer OS (mean 115.5 vs 80.5 months; p=0.0015). The mastectomy group had fewer patients with tumor size T1 (p=0.001) and higher proportions of T3 (p=0.001) and T4 (p=0.02). On multivariate analysis, tumor size T3/T4 and nodal status N2/N3 were significant factors for reduced DFS (p=0.023 and p=0.0003 respectively). Tumor size T3/T4 was the only significant prognostic factor for reduced OS (p=0.019). Conclusion: Advanced disease exhibited by tumor size > 5cm and positive nodal status is associated with poorer DFS in TNBC patients. Radiotherapy technique or fractionation protocol were not associated with differences in DFS or OS in our patient cohort.

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Evaluation of the Survival Benefit of Different Chemotherapy Regimens in Patients with T1-2N0 Triple-Negative Breast Cancer

Cited by 14 publications

References 27 publications

Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection

Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection

Lymphovascular invasion as a negative prognostic factor for triple-negative breast cancer after surgery

<p>Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients</p>

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