Evaluation of the Soothing and Protective Properties of a Lignin Hydrolyzate

Abstract

Lignins have shown remarkable antioxidant properties; acting as “scavengers” of free radicals physiologically produced by cell metabolisms; and exerting a protective action caused by the strong ability of these molecules to absorb UV radiation. Through preliminary Molecular Modeling studies and experimental studies in vivo and in vitro, a lignin hydrolysate compound has been shown to be an extremely versatile active ingredient, presenting soothing, anti-inflammatory, anti-itch, anti-oxidant, anti-aging and anti-pollution properties. The possible fields of application are therefore multiple; making this lignin hydrolysate a particularly interesting ingredient for topical dermatological compositions in the treatment of various skin disorders such as inflammation, edema, swelling, rash, redness, itching, chrono- and photo-induced skin aging. These manifestations are also the basis of more or less serious skin problems, making lignin hydrolysate capable of being used in cosmetic products for the eternal challenge of fighting skin aging, but also in medical devices that can be used to fight more painful and annoying symptoms, like those caused by dermatitis or psoriasis.

Lignin and Cellulose Blends as Pharmaceutical Excipient for Tablet Manufacturing via Direct Compression

“…However, when LIG/MCC blends were used as excipients they showed crushing strength (resistance to crushing) values higher than 200 N. These values were lower than the ones obtained for tablets formulated using MCC as binder. Nevertheless, LIG present other properties that can provide added value to the final product, such as antimicrobial and antioxidant properties [24,25,26,27,28].…”

“…This compound provides mechanical protection to the plant. Moreover, LIG protects the plants from external biological and chemical stresses as it possesses antioxidant and antimicrobial properties [24,25,26,27,28]. LIG is one of the most abundant polymers on Earth, second after cellulose [11,22,29,30].…”

A Practical Approach for the In Vitro Safety and Efficacy Assessment of an Anti-Ageing Cosmetic Cream Enriched with Functional Compounds

“…The soothing effect of a cosmetic product should result in the decrease of pro-inflammatory biometric parameters. Interleukin-6 (IL-6) is one of the most well-known inflammatory markers; it plays a key role in host defense mechanisms, immune response, acute phase reactions and keratinocyte activation [24]. The content of IL-6 after treatment with the tested product, Ceramide Shield Cream, was evaluated in HaCaT cells after 24 h of treatment using an enzyme-linked immunosorbent assay (ELISA) kit (Thermo Fisher, Waltham, MA, USA).…”