Evaluation of the Small-animal Nano Scan PET/CT System using 89Zr

Abstract

Introduction: The purpose of the present work was to evaluate the imaging characteristics of 89Zr-PET in comparison with those obtained using fluorine-18 Fluorodeoxyglucose (18F-FDG) PET (a gold standard tracer in PET imaging) using a small-animal NanoScan PET/CT scanner. Methods: The system’s spatial resolution, sensitivity, uniformity, and image quality were measured on a Nano Scan small-animal PET/CT scanner according to the NEMA NU4-2008 protocols. For reconstruction images, we used 2D and 3D reconstruction algorithms. The reconstruction methods included filter back projection (FBP), the ordered subsets expectation maximization (OSEM) algorithm, and the 3D Tera-Tomo algorithm, which are developed for the NanoScan small-animal PET/CT scanner. Results: The results obtained showed a significant difference in the spatial resolution for 89Zr as compared to 22Na and 18F when using a 2D reconstruction algorithm. Where the spatial resolution values were much enhanced by using the 3D Tera-Tomo reconstruction for each isotope, the Full width at half maximum (FWHM) values were less than 1 for all isotopes at the center of the field of view (FOV). This difference in spatial resolution is dependent on the positron range, energy and the reconstruction method. Conclusion: The long half-life of 89Zr makes it an ideal positron emitter for performing immuno-PET, which is matched with the biological half-life of intact mAbs. 89Zr can also give several advantages over other long half-life positron emitters in relation to the overall imaging performance because of its relatively short positron range and simpler decay scheme. The values of 89Zr sensitivity that were obtained in the present study were less than those of previous studies.

Characteristics of Tight Oil Reservoir Based on Nano-CT

“…Taheri-Ledari R proposed a promising heterogeneous nanoscale catalytic system composed of chitosan, iron oxide nanoparticles, and copper oxide nanoparticles [13]. e aim of Alzimami K was to evaluate the imaging properties of standard tracers and to perform scanner comparisons with gold standard tracers in fluorodeoxyglucose imaging obtained using small animal standard tracers [14]. Although many people have been very rich in nano-CT research, few people realize that it is very meaningful to apply this technology to the exploration of tight oil.…”

Feasibility of positron range correction in 82-Rubidium cardiac PET/CT

“…These results are in accordance with earlier research applying PRC to PET image reconstruction, where the spatial resolution and boundary delineation would increase, while the noise in the image would also increase, especially at boundaries between low and high activity [ 12 , 18 ]. To the best of our knowledge, no research has demonstrated the effect of PRC for 82 Rb in in a NEMA NU-4 phantom, but it has been demonstrated for 89 zirconium [ 19 ], 124 iodine [ 13 ] and 68 gallium ( 68 Ga) [ 11 ]. These studies also found an increase in %SD and RC, with a decrease in SOR.…”

Feasibility of positron range correction in 82-Rubidium cardiac PET/CT

“…These results are in accordance with earlier research applying PRC to PET image reconstruction, where the spatial resolution and boundary delineation would increase, while the noise in the image would also increase, especially at boundaries between low and high activity (12,18). To the best of our knowledge, no research has demonstrated the effect of PRC for 82 Rb in in a NEMA NU-4 phantom, but it has been demonstrated for 89 Zirconium (19), 124 Iodine(13) and 68 Gallium ( 68 Ga) (11). These studies also found an increase in %SD and RC, with a decrease in SOR.…”