Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification

Lee, Jong Lyul; Kim, Mee-Jeong; Kim, Jihun; Kim, Chan Wook; Ha, Ye Jin; Kim, Seon‐Young; Cho, Dong‐Hyung; Kim, Jin Cheon

doi:10.1016/j.asjsur.2021.01.012

Cited by 8 publications

(12 citation statements)

References 18 publications

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“…In summary, the overall survival in our study is in line with those of previous similar studies (Table 3) (11,13,14,17,21). Overall survival correlated well with PSOGI class (Figure 2).…”

Section: Comparison With Previous Studiessupporting

confidence: 92%

“…Most patients (65%) had no (PSS 0) or limited (PSS 1) surgery prior to their CRS + HIPEC. The median PCI score was 25 [interquartile range (IQR), [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. 210 patients (94%) were treated with CRS + HIPEC, and a CC score of 0/1 was achieved in 184 (88%) of these procedures.…”

Section: Demographymentioning

confidence: 99%

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Validating the PSOGI classification of peritoneal disease from non-carcinoid epithelial appendiceal neoplasms in the curative and palliative setting: an observational retrospective study

Farrokhnia¹,

Benoni²,

Ghanipour³

et al. 2022

J Gastrointest Oncol

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Background: Few studies on long-term survival have been published since the new updated pseudomyxoma peritonei (PMP) classification was published in 2016. The aim was to investigate longterm survival according to the Peritoneal Surface Oncology Group International (PSOGI) classification and compare prognostic factors.Methods: From Uppsala University Hospital, consecutive patients referred for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) from 2004 to 2017 with peritoneal disease from non-carcinoid mucinous epithelial appendiceal neoplasms were included in the study. The peritoneal disease was divided into four groups: mucin only, low-grade mucinous carcinoma peritonei (MCP-1), high-grade (MCP-2), and high-grade with signet ring cells (MCP-3). Survival curves were rendered, and prognostic factors were compared. Results:The study included 223 patients: 36 with mucin only, 112 with MCP-1, 70 with MCP-2, and 5 with MCP-3. Thirty-eight patients had a palliative debulking or open/close procedure. The 5-and 10-year overall survival was 97% and 97% for mucin only, 83% and 70% for MCP-1, 69% and 49% for MCP-2, with no patients still under follow-up after 5 years in the MCP-3 group. In a multivariable analysis, completeness of cytoreduction (CC) score 2-3 and PSOGI class MCP-3 were significantly associated with lower survival. The 5-year overall survival in the palliative setting was 40% vs. 44% (MCP-1 vs. MCP-2, P>0.05) with median survival 51 vs. 53 months, respectively. Conclusions:The PSOGI classification of PMP provides a solid differentiation of prognostic groups after CRS/HIPEC treatment, but not in the palliative setting.

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“…In summary, the overall survival in our study is in line with those of previous similar studies (Table 3) (11,13,14,17,21). Overall survival correlated well with PSOGI class (Figure 2).…”

Section: Comparison With Previous Studiessupporting

confidence: 92%

Section: Demographymentioning

confidence: 99%

Validating the PSOGI classification of peritoneal disease from non-carcinoid epithelial appendiceal neoplasms in the curative and palliative setting: an observational retrospective study

Farrokhnia¹,

Benoni²,

Ghanipour³

et al. 2022

J Gastrointest Oncol

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show abstract

“…There were 120 males and 78 females, the mean age was 58 ± 11 years. The median duration from tumor markers detection to CRS was 7 (5,10) days. There were 68 participants underwent radical surgery, while 130 underwent debulking surgery.…”

Section: Resultsmentioning

confidence: 99%

“…Complete cytoreduction surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) were the recommended standard treatment for PMP [4] . The extent of peritoneal involvement was quanti ed by the peritoneal cancer index (PCI) [5] , which is the surgical variable commonly used to determine the feasibility of tumor reduction [6] . PCI is a rather well established scoring system with scores from 0 to 39 and also been employed to re ect tumor burden in PMP patients.…”

Section: Introductionmentioning

confidence: 99%

Tumor Markers Reflect Tumor Burden of Pseudomyxoma Peritonei

Bai

Pang

et al. 2021

Preprint

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Background: Accurate assessment of preoperative tumor burden contribute to formulate a scientific surgical plan and improve the prognosis of patients with pseudomyxoma peritonei (PMP). Present study aimed to assess whether preoperative serum tumor markers could reflect tumor burden. Methods: A total of 198 PMP patients were included, the peritoneal cancer index (PCI) was employed to reflect tumor burden for PMP patients. All participants were divided into low (PCI ≤ 19) and high (PCI ≥ 20) tumor burden subgroups according to PCI. All serum tumor markers (carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), CA 19-9, CA 724, and CA 242) were compared between the two subgroups. The correlation between tumor markers and PCI will be calculated and compared with each other. Two-sided P value less than 0.05 is considered statistically significant.Results: The level of CEA (ng/ml), CA125 (U/ml), CA 19-9 (U/ml), CA 724 (U/ml), and CA 242 (kU/L) between low and high tumor burden subgroup were [3.35 (1.64, 16.31) vs. 23.12 (8.80, 67.62), Z = -5.381, p<0.001], [19.10 (7.61, 56.95) vs. 72.75 (40.41, 130.55), Z = -5.978, p < 0.001], [6.17 (3.26, 16.22) vs. 45.50 (13.95, 123.61), Z = -5.413, p < 0.001], [7.89 (1.57, 45.10) vs. 84.61 (33.87, 236.93), Z = -5.898, p < 0.001], and [13.32 (3.39, 96.50) vs. 150.00 (102.13, 308.88), Z = -5.166, p < 0.001], respectively. The Spearman correlation between tumor markers and PCI were 0.415 for CEA (p < 0.001), 0.372 for CA 125 (p < 0.001), 0.466 for CA 19-9 (p < 0.001), 0.379 for CA 724 (p < 0.001), and 0.317 for CA 242 (p < 0.001), respectively. Conclusions: Preoperative serum tumor markers could moderately reflect tumor burden for PMP, which may contribute to develop a better surgical plan before operation.

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“…Due to the high rate of surgical morbidity, candidate patients should be selected carefully. Lee et al (8) reported that determining the extent of the clinical pathological classification and CC score is crucial to assessing survival outcomes. These findings should be considered when explaining to patients before surgery the benefits and risks of CRS.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound for Preoperatively Predicting Pathology Grade, Complete Cytoreduction Possibility, and Survival Outcomes of Pseudomyxoma Peritonei

et al. 2021

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ObjectivesThis study aimed to investigate the value of using ultrasound (US) preoperatively for predicting pathological classification, complete cytoreduction possibility, and survival rate of patients with pseudomyxoma peritonei (PMP).MethodsWe retrospectively studied PMP patients who were scheduled for cytoreductive surgery between May 2009 and October 2019. US examination was performed before surgery. Factors related to high-grade pathology and poor completeness of cytoreduction (CC) score were identified. Associations between ultrasound characteristics and the survival status were also examined to identify independent predictive factors.ResultsPMP patients with clear ascites, abdominal lymph nodes, omental cake, abdominal mass, portal infiltration, and mesenteric involvement visible on US were considered to have high-grade pathology. Various US features were shown to be independent prognostic markers for inadequate cytoreduction in PMP patients. Portal infiltration and mesenteric involvement were significant prognostic factors for lower survival rates (hazard ratio = 3.092, 3.932, respectively). A visual nomogram including these factors was constructed to predict survival rates. The consistency index was 0.777, which reflected relatively high accuracy.ConclusionsPreoperative US has the potential to predict pathological grade and resectability of PMP. Portal infiltration and mesenteric involvement were independent predictors of poor clinical outcomes in PMP patients. Furthermore, a simple-to-use nomogram derived from our study data may be a helpful visual tool in clinical practice to predict 1-, 2-, and 3-year survival rates for PMP patients.

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Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification

Cited by 8 publications

References 18 publications

Validating the PSOGI classification of peritoneal disease from non-carcinoid epithelial appendiceal neoplasms in the curative and palliative setting: an observational retrospective study

Validating the PSOGI classification of peritoneal disease from non-carcinoid epithelial appendiceal neoplasms in the curative and palliative setting: an observational retrospective study

Tumor Markers Reflect Tumor Burden of Pseudomyxoma Peritonei

Ultrasound for Preoperatively Predicting Pathology Grade, Complete Cytoreduction Possibility, and Survival Outcomes of Pseudomyxoma Peritonei

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