Evaluation of the Serum Visfatin and Adiponectin Levels Related with the Activity of Juvenile Idiopathic Arthritis

Abstract

Objective: Our aim was to investigate the possible relationship of serum adiponectin and visfatin levels that are derived from the adipose tissue, with the activity of juvenile idiopathic arthritis (JIA) in accordance with the routinely used biochemical parameters, to evaluate the management of the therapy and the assessment of the disease activity.Methods: Dependent on the Wallace criteria; the study group is composed of active, remission and control subjects. Serum adiponectin and visfatin levels were measured by the enzyme-linked immunosorbent assay method. Complete blood count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were routinely measured. Neutrophil/lymphocyte ratio (NLR) was calculated.Results: There were statistically significant differences in serum visfatin levels among the active and the control groups (p<0,05) whereas; a statistically signifficant difference was found in serum adiponectin levels between the active and the remission groups (p<0,05). Significant differences were also observed in routinely used parameters; ESR, CRP and platelet counts (p<0,05) among the active, remission and control subjects, whereas the leukocyte and neutrophil counts together with the percentage of neutrophils, lymphocytes and NLR established significant differences only between the active and control groups (p<0.05) Conclusion:We can assume that serum visfatin levels may be useful to indicate the activity of the disease in accordance with the correlation between ESR and CRP in JIA subjects. Unlike visfatin; serum adiponectin levels may be utilized at the management of the therapy rather than the diagnostic parameter on the onset of JIA. Although the present study has been designed within the limited JIA subjects, this research highlights these two adipose tissue derived paramaters as new biochemical parameters in JIA subjects, both in the assessment of the disease activity and management of the therapy, that are essential for the life quality of these patients.

Examining the Relationship between Systemic Immune–Inflammation Index and Disease Severity in Juvenile Idiopathic Arthritis

“…Peripheral leukocyte, neutrophil, and platelet counts gradually increased while hemoglobin levels decreased. This is in keeping with previous studies that noted neutrophilia and thrombocytosis as signs of active disease [61,62]. In our examination of the two hematological indices, both the NLR and SII showed a notable, gradual increase with the severity of the disease.…”

“…In our examination of the two hematological indices, both the NLR and SII showed a notable, gradual increase with the severity of the disease. The median NLR value of the entire study population was 1.63 (IQR: 1.19, 2.31), which is slightly smaller than the previous values reported in active JIA of 2.50 ± 1.89 [ 61 ] and 2.11 ± 1.19 [ 32 ]. The observed difference in NLR values may be influenced by the differing proportions of the JIA subtype and disease severity in the two studies and the difference in descriptive units.…”