Evaluation of the serum sex hormones levels and alkaline phosphatase activity in rats’ testis after administering of berberine in experimental varicocele

Najaran, Hamed; Bafrani, Hassan Hassani; Rashtbari, Hamid; Izadpanah, Fatemeh; Rajabi, Mohammad Taher; Kashani, Hamed Haddad; Mohammadi, Abouzar

doi:10.1007/s13596-019-00369-x

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…It is present in several medicinal plants, such as Berberis vulgaris, Coptis chinensis, Hydrastis canadensis, Coptidis rhizoma, Xanthoriza simplicissima, Phellodendron amurense, and Chelidonium majus. Berberine exhibits unusual biochemical and pharmacological activities, including antidiabetic [1], hypolipidemic [2], antihypertensive [3], anti-inflammatory [4], antidiarrheal [5], hepatoprotective [6], antidepressant [7], anticancer [8], antibacterial [9], and antiviral [10] properties. BBR is capable of penetrating all cell lines, but the cumulative concentration is the highest in Hep G-2 cells [11].…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of berberine

2020

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Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. It has been shown that BBR reduces virus replication and targets specific interactions between the virus and its host. BBR intercalates into DNA and inhibits DNA synthesis and reverse transcriptase activity. It inhibits replication of herpes simplex virus (HSV), human cytomegalovirus (HCMV), human papillomavirus (HPV), and human immunodeficiency virus (HIV). This isoquinoline alkaloid has the ability to regulate the MEK-ERK, AMPK/mTOR, and NF-κB signaling pathways, which are necessary for viral replication. Furthermore, it has been reported that BBR supports the host immune response, thus leading to viral clearance. In this short review, we focus on the most recent studies on the antiviral properties of berberine and its derivatives, which might be promising agents to be considered in future studies in the fight against the current pandemic SARS-CoV-2, the virus that causes COVID-19.

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Section: Introductionmentioning

confidence: 99%

Antiviral activity of berberine

2020

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“…[42][43][44][45][46] All subjects in the two groups were classified and analyzed by statistical tests o� the χ 2 , Mann-Whitney and Fridman tests. [47][48][49][50][51][52] In the present study, a P ≤ 0.05 was considered to be significant.…”

Section: Methodsmentioning

confidence: 99%

Comparison of a novel herbal skin care ointment with regular ointments to treat skin around the abdominal stoma: A clinical trial study

2019

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Introduction The incidence of gastric ulcers in patients with abdominal stoma is high and affects the quality of patients’ life. Aim To evaluate the effect of Adib herbal ointment containing chamomile rose, black nightshade origin versus Comfeel and Conveen ointments on the skin of abdominal stoma. Material and methods This is a clinical study in which the volunteers were stoma patients. Study group consisted of 52 qualified subjects, 26 were included in the experimental group and 26 in the control group. A 2-part questionnaire was used for the data collection. The 1st part was demographic information. The 2nd part of the data collection was evaluated according to the pressure ulcer scale for healing (PUSH) tool, which used for examining skin ulcers around the stoma. P ≤ 0.05 was considered as a significant. Results and discussion The results of the Mann–Whitney test showed that between the mean score of the total score of the wound before intervention (P = 0.92) and on the 3rd day (P = 0.476), 6th (P = 0.222), 9th (P = 0.11) and 12th (P = 0.418), there was no significant difference between the control and test groups. Also, the Friedman test (intra-group) also showed that between the mean score of the total score of the wound before the intervention and the 3rd, 6th, 9th and 12th days in the control group (P = 0.0001) and in the experimental group (P = 0.0001) There was a significant statistical difference. Conclusions Based on the study, Adib herbal ointment could be recommended for the treatment of stoma to the skin as an herbal product as other common treatments.

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“…2, is an isoquinoline alkaloid, known to be biosynthesized by many plant species, particularly those of the genus Berberis from which the compound derives its name. Some medicinal properties of 1 reported include anti-inflammatory [40], antiviral [41], antidiabetic [42], antihypertensive [43], hepatoprotective [44] and anticancer [45], additionally is a widely used dietary supplement due to these medicinal properties. According to Warowicka et al compound 1 could be a possible lead compound against SARS-COV-2, which might act by modulating the nuclear factor kappa of activated B cells (NF-κB) and mitogen-activated protein kinases (MAPKs) [46].…”

Section: Alkaloidsmentioning

confidence: 99%

“…Therefore, the anti-PEDV molecules 35, 38 and 39 could be investigated further as candidates against SARS-CoV-2. Celastrol (36), tingenone (37) pristimerin (40) and iguesterin (41) are quinone methide triterpenoids isolated from the bark of Tripterygium regelii [143]. T. regelii is a vine found widely in China, Korea, Japan, and Taiwan [117].…”

Section: Triterpenoidsmentioning

confidence: 99%

Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2

Ebob

Babiaka

Ntie‐Kang

2021

Nat. Prod. Bioprospect.

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For the past 2 years, the coronavirus responsible for the COVID-19 infection has become a world pandemic, ruining the lives and economies of several nations in the world. This has scaled up research on the virus and the resulting infection with the goal of developing new vaccines and therapies. Natural products are known to be a rich source of lead compounds for drug discovery, including against infectious diseases caused by microbes (viruses, bacteria and fungi). In this review article, we conducted a literature survey aimed at identifying natural products with inhibitory concentrations against the coronaviruses or their target proteins, which lie below 10 µM. This led to the identification of 42 compounds belonging to the alkaloid, flavonoid, terpenoid, phenolic, xanthone and saponin classes. The cut off concentration of 10 µM was to limit the study to the most potent chemical entities, which could be developed into therapies against the viral infection to make a contribution towards limiting the spread of the disease.

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Evaluation of the serum sex hormones levels and alkaline phosphatase activity in rats’ testis after administering of berberine in experimental varicocele

Cited by 7 publications

References 51 publications

Antiviral activity of berberine

Antiviral activity of berberine

Comparison of a novel herbal skin care ointment with regular ointments to treat skin around the abdominal stoma: A clinical trial study

Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2

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